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polymyxin

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Book Chapter
Series: Contributions to Nephrology
Volume: 196
Published: 09 August 2018
10.1159/000485725
EISBN: 978-3-318-06298-4
... by the polymyxin B-immobilized fiber column (PMX). PMX has been used for decades in Europe. Results of a North American randomized controlled trial (RCT) on PMX have recently been announced in a press release; results of large-scale observational studies and meta-analyses have also been reported in the last...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315917
EISBN: 978-3-8055-9485-1
...) is a selective blood endotoxin removal cartridge. PMX is composed of polymyxin B (PL-B) covalently bonded to polystyrene-derivative fibers. It is well known that PL-B binds endotoxin and has bactericidal activity. PL-B has a strong affinity to endotoxin and is able to bind the lipid A portion of endotoxin...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315918
EISBN: 978-3-8055-9485-1
... Abstract The outer leaflet of Gram-negative bacteria membrane contains a great amount of lipopolysaccharides, also known as endotoxins, which play a central role in the pathogenesis of septic shock. It has been demonstrated that the polymyxin B (PMB) molecule has both antibacterial...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315919
EISBN: 978-3-8055-9485-1
... Abstract The removal of blood endotoxins with the Toraymyxin extracorporeal sorption device exploits the capability of immobilized polymyxin B (PMB) to bind endotoxins stably with a high specificity. Although adsorption is a molecular-scale mechanism, it involves hydrodynamic phenomena...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315920
EISBN: 978-3-8055-9485-1
... and organ damage, including acute renal failure. Polymyxin B (PMX-B) hemoperfusion of septic patients can improve survival and decreasing organ dysfunction by removing circulating LPS. Unfortunately, some clinicians have been slow to adopt this novel therapy due to the lack of understanding of the cellular...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315921
EISBN: 978-3-8055-9485-1
..., and is thus an ideal potential therapeutic target. Direct hemoperfusion using polymyxin B-immobilized fiber column (PMX-F) has been shown to bind and neutralize endotoxin in both in vitro and in vivo studies. Therefore, this extracorporeal therapy with PMX-F can potentially interrupt the biological cascade...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315923
EISBN: 978-3-8055-9485-1
... Abstract Background: We evaluated the ability of the endotoxin activity (EA) assay to determine the need for early intervention for endotoxemia using polymyxin B-based hemoperfusion (PMX-DHP) on septic patients. Methods: Twenty-four patients were enrolled. Eleven patients had a high EA...
Book Chapter
Series: Contributions to Nephrology
Volume: 156
Published: 10 May 2007
10.1159/000102138
EISBN: 978-3-318-01456-3
... hemoperfusionwith polymyxin-B-immobilized fiber (PMX-F) is a promising treatment of gramnegativesepsis in critically ill patients. Because of the high affinity of polymyxin B forendotoxin, the rationale underlying extracorporeal therapy would be to remove circulating endotoxinby adsorption, thus preventing...
Book Chapter
Series: Antibiotics and Chemotherapy
Volume: 31
Published: 17 December 1981
10.1159/000400132
EISBN: 978-3-318-03206-2
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000529294
EISBN: 978-3-318-07124-5
... to ensure HP effectiveness. Although the main indication of CytoSorb®, HA330/380, polymyxin B, and Seraph® is sepsis, these devices may be beneficial in many other situations such as liver failure, rhabdomyolysis, pancreatitis, cardiopulmonary bypass, extensive burns, and trauma or to ensure antiplatelet...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527708
EISBN: 978-3-318-07124-5
...-response relationship between endotoxin levels and adverse outcomes. A rapid assay to measure endotoxin activity has been available for more than a decade, but few studies have synergized the assay with a therapeutic. Polymyxin B hemoperfusion (PMX-HP) leverages a molecule with high affinity for endotoxin...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
EISBN: 978-3-318-07124-5
... of human increased sensitivity to lipopolysaccharide. Evol Anthropol. 2021;30(2):141–57. 8. Dellinger RP, Bagshaw SM, Antonelli M, Foster DM, Klein DJ, Marshall JC, et al. Effect of targeted polymyxin B hemoperfusion on 28-day mortality in patients with septic shock and elevated endotoxin level...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
EISBN: 978-3-318-07124-5
... X, Li G, Xiao D, Meng Q, et al. The efficacy of resin hemoperfusion cartridge on inflammatory responses during adult cardiopulmonary bypass. Blood Purif. 2022;51(1):31–7. 20. Klein DJ, Foster D, Walker PM, Bagshaw SM, Mekonnen H, Antonelli M. Polymyxin B hemoperfusion in endotoxemic septic shock...
Book Chapter
Series: Contributions to Nephrology
Volume: 196
Published: 09 August 2018
EISBN: 978-3-318-06298-4
...-controlled study of a polymyxin B-immobilized hemoperfusion cartridge in patients with severe sepsis secondary to intra-abdominal infection. Shock 2005;23:400-405. 9. Cruz DN, Antonelli M, Fumagalli R, Foltran F, Brienza N, Donati A, Malcangi V, Petrini F, Volta G, Bobbio Pallavicini FM, Rottoli F...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
EISBN: 978-3-8055-9485-1
... 3. Kellum JA: A targeted extracorporeal therapy for endotoxemia: the time has come. Crit Care 2007;11-137 4. Shoji H, Tani T, Hanasawa K, Kodama M: Extracorporeal endotoxin removal by polymyxin B immobilized fiber cartridge: designing and antiendotoxin efficacy in the clinical application. Ther...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
EISBN: 978-3-8055-9485-1
...:S57-S64 6. Palmer JD, Rifkind D: Neutralization of the hemodynamic effects of endotoxin by polymyxin B. Surg Gynecol Obstet 1974;138:755-759 7. From AH, Fong JS, Good RA: Polymyxin B sulfate modification of bacterial endotoxin: effects on the development of endotoxin shock in dogs. Infect...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
EISBN: 978-3-8055-9485-1
...:108-114 5. Cruz DN, Bellomo R, Ronco C: Clinical effects of polymyxin B-immobilized fiber column in septic patients. Contrib Nephrol 2007;156:444-451 6. Cruz DN, Perazella MA, Bellomo R, de Cal M, Polanco N, Corradi V, Lentini P, Nalesso F, Ueno T, Ranieri VM, Ronco C: Effectiveness...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315926
EISBN: 978-3-8055-9485-1
... Abstract Since 1994, a polystyrene fiber cartridge used for extracorporeal hemoperfusion, to which polymyxin B is bound and immobilized, has been used in septic patients in order to absorb and remove circulating lipopolysaccharide, thereby neutralizing the effects of this endotoxin...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
10.1159/000315922
EISBN: 978-3-8055-9485-1
... Abstract Polymyxin B fiber column is a medical device designed to reduce blood endotoxin levels in sepsis. Gram-negative-induced abdominal sepsis is likely to be associated with high circulating endotoxin. In June 2009, the EUPHAS study (Early Use of Polymyxin B Hemoperfusion in Abdominal...
Book Chapter
Series: Contributions to Nephrology
Volume: 167
Published: 02 June 2010
EISBN: 978-3-8055-9485-1
...-talk: a new paradigm for understanding the gut as the 'motor' of critical illness. Shock 2007;28:384-393 12. Kellum JA: A targeted extracorporeal therapy for endotoxemia: the time has come. Crit Care 2007;11:137 13. Bhor VM, Thomas CJ, Surolia N, Surolia A: Polymyxin B: an ode to an old...