... and crying (PLC) may be encountered in various neurological diseases: amyotrophic lateral sclerosis, multiple system atrophy (cerebellar), cerebrovascular disease, traumatic brain injuries, mass lesions in the cerebellopontine junction, and epilepsy. After describing the pathophysiology of PLC and the use...

... to be elucidated, but the G q –phospholipase C (PLC) protein kinase C pathway – which is a significant signaling pathway for OXRs in recombinant cells – may be one of the players in neurons. The G q –PLC pathway may also, under certain circumstances, take the route to diacylglycerol lipase, which leads...

... and laughing are substantially unknown. Based on clinical observations, Poeck et al. [ 8 ] differentiated emotionalism into 2 further conditions: pathological laughter and crying (PLC; or pseudobulbar affect) and emotional lability (EL). According to Poeck, crying and laughing have a more motor reflex...

... signaling pathway, agonist binding to neurotransmitter receptors such as 5-HT 2A , 5-HT 2C or α 1 -adrenergic receptors causes activation of G proteins, which then activate the enzyme PI-specific phospholipase C (PI-PLC). PI-PLC then hydrolyzes phosphatidylinositol 4,5 biphosphate (PIP 2 ) and generates...

...-specific phospholipase C (PI-PLC) is a component of the PI signal transduction system and some studies have shown its implication in neuropsychiatric disorders, including suicidal behavior in the young and adults [ 29 , 30 ]. Lo Vasco et al. [ 29 ] reported a reduction of overall PLC expression...

..., β and γ). Subsequently, these subunits stimulate their respective effector pathways: (i) stimulation of phospholipase C (PLC), leading to the generation of inositol triphosphate (IP 3 ) and diacylglycerol (DAG), which activate protein kinase (PK) C; (ii) stimulation of adenylate cylase (AC), which...

.../attachment/401.pdf AccessedAugust 31, 2007; 33. Elan reports third quarter 2006 financial results. [news release]Dublin, Ireland, Elan Corporation, plc;, October 25, 2006; http://www.elan.com/News/2006/20061025.asp AccessedAugust 31, 2007; 34. Polman CH, O'Connor PW, Havrdova E, et al: A randomized...

... adenosine monophosphate; PK-A = protein kinase A; PK-C = protein kinase C; DAG = diacylglycerol; PLC = phospholipase C. Fig. 1. Sites of genetic defects causing hyperinsulinism. For this introductory perspective, this diagram provides a minimalist consensus view, leaving the discussion of further...

... to the Boots star rating system, The Boots Co., PLC: Notthingham; 2011 Revision. 29. Diffey BL, Robson J. A new substrate to measure sunscreen protection factors throughout the ultraviolet spectrum. J Soc Cosmet Chem. 1989;40(3):127–33. 30. Pissavini M, Tricaud C, Wiener G, Lauer A, Contier M, Kolbe L...

... and lifespan via EGF receptor, PLC-gamma, and IP3R activation. Aging Cell 2010;9:490-505. 20497132 10.1111/j.1474-9726.2010.00575.x 15. Ingram DK, Reynolds MA: Assessing the predictive validity of psychomotor tests as measures of biological age in mice. Exp Aging Res 1986;12:155-162. 3830235 10.1080...