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phlorizin

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Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
10.1159/000506566
EISBN: 978-3-318-06734-7
... Abstract Josef von Mering discovered the glucosuric effect of phlorizin. Phlorizin is the progenitor of contemporary SGLT2 inhibitors. Von Mering also described the blood glucose-lowering effect of phlorizin and postulated that the action of phlorizin occurs in the kidney – a hypothesis which...
Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
10.1159/000506563
EISBN: 978-3-318-06734-7
..., that important “discoveries” were made by obscure others way before bold announcements or, alternatively, that not much had been discovered after all. For example, the ketogenic effects of the plant extract phlorizin, later transformed into modern SGLT inhibitors, was described by von Mering in 1887, before...
Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
10.1159/000506549
EISBN: 978-3-318-06734-7
... on his discovery of the glucosuric effect of phlorizin in 1885 [ 5 ]. Their discussion took place in the library of Prof. Hoppe-Seyler’s institute of biochemistry (the first of its kind worldwide) and von Mering had the “home field advantage.” Decades later there was some discussion concerning...
Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
EISBN: 978-3-318-06734-7
... series V – acidosis. 5. Acidosis in phlorizinized dogs. J Metab Res 1923;4:223–254. 19. Mirsky IA: The etiology of diabetic acidosis. Proc Am Diabetes Assoc 1941;1:49–68. 20. Leslie BR, Leslie EG, Taylor SI: Sodium-glucose co-transporter-2 inhibitors: lack of complete history delays diagnosis...
Book Chapter
Series: Endocrine Development
Volume: 31
Published: 27 January 2016
10.1159/000439372
EISBN: 978-3-318-05639-6
...%. SGLT-1 has a much higher prevalence in the intestine [ 22 , 23 ]. During the 19th century, it was already observed that phlorizin, an alkaloid extracted from apple-tree bark, is able to cause glucosuria. It became evident later that phlorizin acts like an unspecific SGLT inhibitor. Due to its side...
Book
Book Cover Image
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
10.1159/isbn.978-3-318-06734-7
EISBN: 978-3-318-06734-7
Book Chapter
Series: Contributions to Nephrology
Volume: 170
Published: 08 June 2011
10.1159/000325671
EISBN: 978-3-8055-9743-2
... of the SGLT2 receptors and GLUT2 mRNA. SGLT2 antagonism provides an interesting therapeutic option to decrease glucose loads in diabetes. Nonspecific SGLT2 inhibitors like phlorizin have disturbing gastrointestinal side effects. More specific inhibitors like dapagliflozin and sergliflozin are being tested...
Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
10.1159/000506558
EISBN: 978-3-318-06734-7
... and pharmacologic mechanisms. Following the discovery and physiology of incretin hormones, dipeptidyl peptidase-4 inhibitors and glucagon-like peptide-1 receptor agonists were designed, tested, and approved for clinical use. Following basic studies with phlorizin treatment of diabetic animal models, sodium-glucose...
Book
Book Cover Image
Series: World Review of Nutrition and Dietetics
Volume: 40
Published: 09 August 1982
10.1159/isbn.978-3-318-04224-5
EISBN: 978-3-318-04224-5
Book
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Series: Contributions to Nephrology
Volume: 6
Published: 10 January 1977
10.1159/isbn.978-3-318-03270-3
EISBN: 978-3-318-03270-3
Book
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Series: Monographs in Virology
Volume: 7
Published: 13 March 1974
10.1159/isbn.978-3-318-04029-6
EISBN: 978-3-318-04029-6
Book
Book
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Published: 31 December 1950
10.1159/isbn.978-3-318-05066-0
EISBN: 978-3-318-05066-0
Book
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Series: Frontiers in Diabetes
Volume: 14
Published: 18 June 1998
10.1159/isbn.978-3-318-00272-0
EISBN: 978-3-318-00272-0
Book
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Series: World Review of Nutrition and Dietetics
Volume: 57
Published: 27 July 1988
10.1159/isbn.978-3-318-04241-2
EISBN: 978-3-318-04241-2
Book
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Series: Endocrine Development
Volume: 31
Published: 27 January 2016
10.1159/isbn.978-3-318-05639-6
EISBN: 978-3-318-05639-6
Book
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Series: Forum of Nutrition
Volume: 22
Published: 16 May 1975
10.1159/isbn.978-3-318-03580-3
EISBN: 978-3-318-03580-3
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Series: Chemical Immunology and Allergy
Volume: 7
Published: 01 March 1963
10.1159/isbn.978-3-318-01677-2
EISBN: 978-3-318-01677-2
Book
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Series: World Review of Nutrition and Dietetics
Volume: 58
Published: 08 June 1989
10.1159/isbn.978-3-318-04242-9
EISBN: 978-3-318-04242-9
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Series: Nestlé Nutrition Institute Workshop Series
Volume: 62
Published: 12 August 2008
10.1159/isbn.978-3-8055-8554-5
EISBN: 978-3-8055-8554-5