... Abstract The systemic administration of antibiotics in conjunction with mechanical biofilm disruption results in reduced numbers of subgingival periodontal pathogens and improved clinical outcomes. Penicillins, tetracyclines, macrolides, quinolones, and nitroimidazoles were used in laboratory...

... Abstract During the last decade, photodynamic therapy (PDT) has been extensively investigated for the treatment of periodontal and peri-implant infections. Nonetheless, contradicting clinical and microbiological outcomes and only results on a short-term basis have been reported so far, thus...

... Abstract Due to the increasing focus on host inflammatory processes with regard to the aetiology of periodontal disease, diet has become an important factor in host modulation. Recent investigations showed that the industrialized western diet, which is characterized by highly processed foods...

... Abstract The periodontal ligament (PDL) and alveolar bone are two critical tissues for understanding orthodontic tooth movement. The current literature is replete with descriptive studies of multiple cell types and their matrices in the PDL and alveolar bone, but is deficient with how stem...

... Abstract Periodontitis is a chronic inflammatory disorder affecting nearly 50% of adults in the United States. If left untreated, it can lead to the destruction of both soft and mineralized tissues that constitute the periodontium. Clinical management, including but not limited to flap...

... may result in chronic inflammation, which may lead to tissue destruction, as evident in chronic periodontitis. Although many organisms are present in the subgingival biofilm, interestingly, the putative pathogens associated with gingivitis and periodontitis may comprise very small fractions...

... the innate and adaptive arms of the immune response, and help promote inflammatory resolution and tissue healing. Found extensively within the gingival crevice and epithelium, neutrophils are considered the key protective cell type in the periodontal tissues. Histopathology of periodontal lesions indicates...

... Abstract The development of oral biofilms and the host response to biofilm bacteria and their toxins are important factors in the development of periodontal disease. An early component of the host response is the secretion of antimicrobial proteins and peptides (AMPs) by salivary glands, oral...

... Abstract Antibiotics are generally an efficient means of treating bacterial infections, and therefore are an obvious candidate in the treatment of periodontal diseases. Systemically and locally administered antimicrobial agents of all kinds have been evaluated in multiple clinical trials...

... Abstract Traditional treatment for loss of bone and attachment due to periodontal disease has focused around repairing the damage induced. However, over the past few decades, clinicians have begun to utilize regenerative techniques to rebuild bone, cementum and the periodontal ligament...

... Abstract It is becoming clear that variations in inflammatory response are a major determinant in susceptibility to periodontitis. However, our understanding of the relationship of the causal agents in periodontitis to the pathogenesis is not as clear as we once thought, and thus therapies...

... ± 2.5 years), apical periodontitis, rhinosinusitis, and otitis media were identified in 21 (53%, 4.9 ± 2.8 affected teeth), 19 (48%), and 4 (10%) of them, whereas in 11 IgAN children (10.4 ± 2.5 years), these diseases were observed in 6 (55%, 5.8 ± 4.6 affected teeth), 2 (18%), and 0 (0%) of them...