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Book Chapter
Book Chapter
Series: Frontiers of Hormone Research
Volume: 40
Published: 19 October 2012
10.1159/000341683
EISBN: 978-3-318-02239-1
... Abstract Polycystic ovary syndrome (PCOS) is a common metabolic and reproductive disorder in women. An increased cardiovascular risk has to be anticipated in PCOS as it is a metabolically unstable condition. Among cardiovascular risk factors, dyslipidemia is certainly the most persistent...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 53
Published: 16 October 2019
10.1159/000494899
EISBN: 978-3-318-06471-1
... Abstract In utero androgen excess reliably induces polycystic ovary syndrome (PCOS)-like reproductive and metabolic traits in female monkeys, sheep, rats, and mice. In humans, however, substantial technical and ethical constraints on fetal sampling have curtailed safe, pathogenic exploration...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 53
Published: 16 October 2019
10.1159/000494910
EISBN: 978-3-318-06471-1
... Abstract Most research efforts addressing the pathophysiology of polycystic ovary syndrome (PCOS) applied targeted approaches focusing on specific genes and/or proteins that were selected on the basis of previous knowledge about their putative roles in metabolic and signalling pathways...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 49
Published: 26 April 2018
10.1159/000485995
EISBN: 978-3-318-06335-6
... Abstract Both prevalence and incidence of the metabolic syndrome is very high in women with polycystic ovary syndrome (PCOS). Obesity and visceral fat enlargement play a dominant role in determining the final phenotype of PCOS. Androgen excess and insulin resistance may be responsible...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 40
Published: 19 October 2012
10.1159/000341682
EISBN: 978-3-318-02239-1
... Abstract Polycystic ovary syndrome (PCOS) is an oligogenic condition, with a heritability of ∼70%. PCOS is also associated with obesity, which itself is heavily influenced by genetic variants. PCOS is inherently difficult to study genetically, and most of the current literature (>70 studies...
Book Chapter
Series: Frontiers in Diabetes
Volume: 22
Published: 10 April 2014
10.1159/000357250
EISBN: 978-3-318-02598-9
... Abstract The polycystic ovary syndrome (PCOS), the most common disorder characterized by hyperandrogenism and ovarian dysfunction, is often associated with metabolic alterations, chiefly insulin resistance and obesity. Based on available scientific evidence, PCOS should be regarded...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 40
Published: 19 October 2012
10.1159/000341846
EISBN: 978-3-318-02239-1
... Abstract Amongst the commonest endocrine symptoms encountered in premenopausal women are those related to excessive androgen secretion or action, along with menstrual irregularity. The vast majority of women presenting with such symptoms will be found to have the polycystic ovary syndrome (PCOS...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 40
Published: 19 October 2012
10.1159/000341673
EISBN: 978-3-318-02239-1
... Abstract Polycystic ovary syndrome (PCOS) constitutes a continuum spectrum of symptoms starting from the early prepubertal years and continuing after menopause. The phenotypic expression varies through time, depending on several internal (e.g. ovarian/adrenal steroidogenesis, insulin resistance...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 40
Published: 19 October 2012
10.1159/000341838
EISBN: 978-3-318-02239-1
... Abstract In addition to its effects on reproductive health, it is now well recognized that polycystic ovary syndrome (PCOS) is a metabolic disorder, characterized by decreased insulin sensitivity which leads to an excess lifetime risk of type 2 diabetes and cardiovascular disease. PCOS patients...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 40
Published: 19 October 2012
10.1159/000341679
EISBN: 978-3-318-02239-1
... Abstract The cardinal features of polycystic ovary syndrome (PCOS) are hyperandrogenism and oligoanovulation. The increase in ovarian androgen production is a fundamental characteristic of PCOS and, although enigmatic, it is at the heart of one of the major issues about the pathophysiology...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 40
Published: 19 October 2012
10.1159/000342179
EISBN: 978-3-318-02239-1
... and subfertility. The resemblances between NCAH and polycystic ovary syndrome (PCOS) are manifest, and a relation between the two has been sought by many authors trying to identify subtle alterations in the CYP21 gene transcription end-products as the cause or a contributing cause of PCOS. On the other hand...
Book
Book Cover Image
Series: Frontiers of Hormone Research
Volume: 40
Published: 19 October 2012
10.1159/isbn.978-3-318-02239-1
EISBN: 978-3-318-02239-1
Book Chapter
Series: Frontiers of Hormone Research
Volume: 53
Published: 16 October 2019
10.1159/000496415
EISBN: 978-3-318-06471-1
... to being responsible for infertility. Undoubtedly, the polycystic ovary syndrome (PCOS) is the most common androgen excess disorder worldwide, and although this disorder is not the main focus of this book, some particular aspects are still discussed. One relevant part of this book focuses...
Book Chapter
Series: Endocrine Development
Volume: 22
Published: 30 July 2012
10.1159/000326688
EISBN: 978-3-8055-9337-3
... Abstract When the symptoms of hyperandrogenism are mild in an adolescent girl, it is difficult to establish whether they are related to the physiological androgenization of puberty or to an incipient disease. The most frequent etiology is the polycystic ovary syndrome (PCOS). Its diagnosis...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 40
Published: 19 October 2012
10.1159/000341824
EISBN: 978-3-318-02239-1
... Abstract Management of patients with polycystic ovary syndrome (PCOS) who wish to become pregnant should include exclusion of other diseases in the woman and additional fertility disorders in the couple. Before the initiation of any pharmacological intervention, the importance of lifestyle...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 80
Published: 15 December 2014
10.1159/000360259
EISBN: 978-3-318-02672-6
... Abstract Polycystic ovary syndrome (PCOS) is the commonest endocrine condition encountered in young women and has many reproductive, metabolic and psychological features that lead to patients consulting medical practitioners and the health service. Overweight and obesity are common among many...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 53
Published: 16 October 2019
10.1159/000494904
EISBN: 978-3-318-06471-1
... Abstract Although polycystic ovary syndrome (PCOS) is the most common androgen excess disorder, screening for Cushing’s Syndrome (CS) should be considered in women with PCOS phenotype, particularly if they are also affected by other disturbances that increase their pretest probability (e.g...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 40
Published: 19 October 2012
10.1159/000341837
EISBN: 978-3-318-02239-1
... Abstract From the conceptual point of view, there are several reasons to expect that improvement of insulin sensitivity may produce several benefits in the treatment of a complex disorder like polycystic ovary syndrome (PCOS), including a decrease in insulin and androgen levels, improvement...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 53
Published: 16 October 2019
10.1159/000494908
EISBN: 978-3-318-06471-1
... excess may also suggest the potential development of the polycystic ovary syndrome (PCOS). A new hypothesis, based on long-term lifestyle intervention programs or bariatric surgery, supports the concept that a “PCOS secondary to obesity” may exist, as confirmed by the complete resolution of all features...