... Abstract Over the past decade, the neonatal literature has undergone dynamic swings vis a vis its approach to patent ductus arteriosus (PDA) therapeutics, from aggressively closing all PDA's to permissive tolerance of ductal shunting. We propose that ductal closure with paracetamol can satisfy...

..., Grunkemeier G, et al: Permissive tolerance of the patent ductus arteriosus may increase the risk of chronic lung disease. Research and Reports in Neonatology 2013;3:5-10. 14. Hammerman C, Bin-Nun A, Markovitch E, Schimmel MS: Ductal closure with paracetamol: a surprising new approach to patent ductus...

... and reverses thrombus formation after abdominal aorta anastomosis, affects many central disturbances (i.e. dopamine and 5-HT system), the NO system (either l-arginine and L-NAME effects), acts as free radical scavenger (counteracting CCl4, paracetamol and diclofenac injuries) and exhibits neuroprotective...

... anti-inflammatory drugs like paracetamol and disappear normally after some days. Depression(8%) and mild leukopenia (30%) are additional side effects of concern; all other side effects are reported to appear in ≤1% of cases. This chapter updates the mechanisms and pharmacology of IFN and its effects...

... into morphine by CYP2D6. However, metabolism can also result in the formation of a toxic compound, as in the example of paracetamol hepatotoxicity caused by N-acetyl-p-benzoquinone-imine, which is produced by the action of the oxidative enzyme CYP2E1. This toxic reaction occurs when levels of glutathione...

... to all NSAIDs that preferentially inhibit COX-1 ( table 2 ). Acetaminophen (paracetamol), a weak inhibitor of COX-1, is regarded as a relatively safe therapeutic alternative for almost all patients with AIA. High doses of the drug (≥ 1,000 mg) have been reported to provoke mild, easily reversed...

... of phenacetin and paracetamol abuse. Eur Urol 1986; 12: 327-330 9. Burrell JH Yong JL Macdonald GJ: Experimental analgesic nephropathy: changes in renal structure and urinary concentrating ability in Fischer 344 rats given continuous low doses of aspirin and paracetamol. Pathology 1990; 22: 33-44...

..., Smith KR, Culnane TJ, McNally CM, Perkins EJ, Chalkiadis GA, Hunt RW: I.V. acetaminophen pharmacokinetics in neonates after multiple doses. Br J Anaesth 2008;101:523-530. 57. van der Marel CD, Anderson BJ, van Lingen RA, Holford NH, Pluim MA, Jansman FG, van den Anker JN, Tibboel D: Paracetamol...

... publications, women seem to be affected more often than men [ 6 ], especially in association with acetaminophen (paracetamol), and pregnancy may also play a role [ 7 ]. The issue of genetic predisposition is yet to be clarified, but in a study by Bernard et al. [ 8 ] HLA B51, DR11 and DQ3 were found to be more...

... and reversed by stable gastric pentadecapeptide BPC 157 (PL-10, PLD-116), and propranolol, but not ranitidine. J Physiol Paris 2001;95:315-324 27. Ilic S, Drmic D, Zarkovic K, et al: High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction...

..., Cagliari (Italy), October 26–31, 2015. ABS 34. J Pediatr Neonat Individual Med 2015;4:e040250. 35. Bardanzellu F, Neroni P, Dessì A, et al: Paracetamol in patent ductus arteriosus treatment: efficacious and safe? Biomed Res Int 2017;2017:1438038. 36. Atzori L, Barberini L, Lussu M, et al...

... journals in Germany published obituaries – nine in total [ 24 , 25 ]. They pointed out his widespread interest in medical research and highlighted as his major discoveries: pancreatic diabetes, the barbiturate Veronal, and paracetamol. Nobody could imagine that his discovery of phlorizin-diabetes would...

... and molecular pathophysiology of cutaneous drug reactions. Am J Clin Dermatol 2002;3:229-238 43. Halevy S, Cohen A, Livni E: Acute generalized exanthematous pustulosis associated with polysensitivity to paracetamol and bromhexine: the diagnostic role of in vitro interferon-gamma release test. Clin Exp...

... and in this way communicating the injury to the immune system [ 8 ]. Paracetamol has also been implicated in causing ALF. HMGB1 is released from apoptotic and necrotic cells [ 3 ]. HMGB1 levels have been found to be increased in patients with acetaminophen-induced liver injury and are more sensitive than ALT...

... the salicylic acid from) and ‘in', a familiar name ending for medicines. In fact, ASA had been manufactured by the Chemische Fabrik von Heyden & Co. since 1897 without a brand name. Aspirin's popularity declined after the development of acetaminophen/paracetamol in 1956 and ibuprofen in 1962. Mechanisms...

..., improvements are seen in pain and sleep scores and in scoring on the Fibromyalgia Impact Questionnaire [ 31 ]. Nonsteroidal Anti-inflammatory Drugs (NSAIDs), Paracetamol, and Opiates. There is no evidence for the benefit of either NSAIDs or paracetamol. This should be explained to patients early...

... drugs, regional differences were found: whereas in France paracetamol/ acetaminophen seems to be the most common substance inducing FDE, followed by NSAIDs [ 16 ], a Turkish study found sulfamethoxazole/trimethoprim followed by naproxen, dyprone, dimenhydrinate and paracetamol to be the most frequent...