... Abstract Normal development of the palate depends on spatial and temporal coordination of complex cellular processes and tissue-tissue interactions. Because these processes are quite sensitive to environmental and genetic perturbation, clefts of the palate are among the most common congenital...

... Abstract The Sonic hedgehog ( Shh ) gene encodes a secreted signalling molecule that plays an important role during numerous aspects of vertebrate development. In the developing palate, Shh is strongly expressed in the epithelium on the oral surface, in a series of stripes corresponding...

... Abstract The fibroblast growth factor (FGF) signalling pathway is critically involved in several aspects of craniofacial development, including formation of the lip and the palate. FGF receptors are activated by extracellular FGF ligands in order to regulate cellular processes such as migration...

... with or without palate. Formation of the upper lip and palate is a complicated process and is composed of a series of highly coordinated steps during tissue morphogenesis, which are rigorously controlled by genetic networks. While genetic controls of lip/palate development have been extensively studied, the roles...

... anatomy of this region, optimal timing for surgical repair and current thinking on the use of surgical adjuncts. In addition, an overview of current surgical techniques available for the repair of cleft lip, cleft palate and velopharyngeal insufficiency is presented. Finally, we briefly discuss nasal...

... Abstract This chapter describes the normal development of speech and speech problems that may arise for the child born with cleft lip and/or palate. It describes current trends and the importance of multidisciplinary working in this complex field. The contribution of the speech and language...

... Abstract Initially described in 1981, uvulopalatopharyngoplasty was the first surgical procedure specially designed at the palatal level for snoring and obstructive sleep apnea (OSA). To date, palatal surgery remains the most commonly used surgery for OSA. The advancement of this surgery over...

... Abstract The orthodontic treatment of patients with all types of cleft lip and palate, a resume of facial growth and discussion on dental and occlusal development is presented. A fully integrated cleft team provides life-long interdisciplinary holistic treatment for patients born...

... Abstract Cleft lip and palate is the most common craniofacial birth defect and its etiology has been the focus of many reports in the literature. It is well accepted that both genetics and environment play a role in the condition, however we still have not been able to translate what have been...

... conditions. This small mammal’s usefulness in cleft lip and palate research stems not only from the striking anatomical and molecular similarities of lip and palate development between human and mouse embryos, but also from its amenability to experimental and genetic manipulation. Using some recent studies...

... Abstract Cleft lip with or without cleft palate (CLP) and cleft palate only (CP) are severe disruptions affecting orofacial structures. Patients with orofacial clefts require complex interdisciplinary care, which includes nursing, plastic surgery, maxillofacial surgery, otolaryngology, speech...

... and palate treatment require time, money and large samples. Although clefting is a common congenital anomaly in man (1:700 live births), because of the variation in phenotypic expression it is difficult to collect, from a single centre, sufficient numbers to randomize to specific treatments. Not surprisingly...

... Abstract Dr. Leonard Furlow first described the double-reversing z-plasty technique for cleft soft palate repair in 1978. This approach allows for repair of an overt or submucous cleft palate, but just as an importantly, provides additional length to the palate and also realigns the palatal...

... status and oral impacts on quality of life in early adolescent cleft patients. J Med Assoc Thai. 2014 Oct;97(Suppl 10):S7–16. 31. Chopra A, Lakhanpal M, Rao NC, Gupta N, Vashisth S. Oral health in 4–6 years children with cleft lip/palate: a case control study. N Am J Med Sci. 2014 Jun;6(6):266–9...