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Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522458
EISBN: 978-3-318-07054-5
... for the cellular and molecular mechanisms of brain stem death began with the pro-life and pro-death roles of nitric oxide (NO) in the RVLM. NO was first identified as a gas by Joseph Priestly in 1772 [ 1 ], and for a long time since its discovery has been thought of simply as an atmospheric pollutant. It became...
Book Chapter
Series: Contributions to Nephrology
Volume: 174
Published: 15 September 2011
10.1159/000329249
EISBN: 978-3-8055-9811-8
... regulated and utilized not only for mitochondrial production of ATP (mainly for Na reabsorption), but also for the production of nitric oxide and the reactive oxygen species needed for physiological control of renal function. Under pathological conditions, such as inflammation, shock or sepsis, however...
Book Chapter
Series: Contributions to Nephrology
Volume: 172
Published: 01 September 2011
10.1159/000329054
EISBN: 978-3-8055-9795-1
... Abstract The mechanism(s) of the endothelin (ET) and reactive oxygen species pathways in conjunction with the nitric oxide (NO) pathway that promote and/or blunt the progression of diabetic kidney disease have been the focus of many laboratories’ efforts to reveal new therapeutic targets...
Book Chapter
Series: Contributions to Nephrology
Volume: 170
Published: 08 June 2011
10.1159/000324954
EISBN: 978-3-8055-9743-2
... lacking endothelial nitric oxide synthase (eNOS). Diabetic eNOS knockout mice develop severe renal injuries resembling advanced human diabetic nephropathy. This model thereby suggests a key role for reduced nitric oxide levels in the pathogenesis of diabetic nephropathy. In this article, we summarize...
Book Chapter
Published: 01 February 2011
10.1159/000321941
EISBN: 978-3-8055-9665-7
... Abstract Inhaled nitric oxide (NO) is a selective pulmonary vasodilator because it does not reduce systemic blood pressure. Inhaled NO dilates constricted pulmonary vessels by activating guanylate cyclase of pulmonary vascular smooth muscle cells and is inactivated by hemoglobin when...
Book Chapter
Published: 01 February 2011
10.1159/000322094
EISBN: 978-3-8055-9665-7
... Abstract Inhaled nitric oxide is a potent pulmonary vasodilator, having clinically useful properties in improving pulmonary gas exchange and reducing pulmonary vascular resistance. It was officially approved for the clinical use in neonatal persistent pulmonary hypertension (PPHN) and has been...
Book Chapter
Series: Forum of Nutrition
Volume: 61
Published: 27 April 2009
10.1159/000212751
EISBN: 978-3-8055-9098-3
... Abstract A regulated low level of nitric oxide (NO) production in the body is essential for maintaining homeostasis (neuroprotection, vasorelaxation, etc.), though certain pathophysiological conditions associated with inflammation involve de novo synthesis of inducible NO synthase (iNOS...
Book Chapter
Book Chapter
Series: Progress in Respiratory Research
Volume: 33
Published: 04 February 2005
10.1159/000083534
EISBN: 978-3-318-01087-9
... is increasingevidence that breath analysis may have an important placein the diagnosis and clinical management of asthma, primaryciliary dyskinesia and other major lung disease in children.This chapter reviews different methodologies of measuringexhaled nitric oxide in uncooperative and cooperative children...
Book Chapter
Series: Progress in Respiratory Research
Volume: 33
Published: 04 February 2005
10.1159/000083535
EISBN: 978-3-318-01087-9
... Abstract The major part of nitric oxide (NO) in exhaled air originatesfrom the nasal airways, with only minor contributionfrom the lower airways and the oral cavity. The physiologicalrole of the very high local NO concentration in theparanasal sinuses is still unclear. The most widely used...
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Series: Contributions to Nephrology
Volume: 125
Published: 11 December 1998
10.1159/000059959
EISBN: 978-3-318-00349-9