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osteopontin

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Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 94
Published: 09 June 2020
10.1159/000505067
EISBN: 978-3-318-06685-2
... Abstract Osteopontin (OPN) is an acidic phosphorylated glycoprotein involved in a wide range of biological activities, such as cell proliferation and differentiation, as well as immunomodulatory functions. OPN contains integrin and CD44 binding sites, and it exerts its multiple functions...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 94
Published: 09 June 2020
EISBN: 978-3-318-06685-2
...References References 1. Rittling SR, Singh R: Osteopontin in immune-mediated diseases. J Dent Res 2015;94:1638–1645. 2. Selvaraju R, Bernasconi L, Losberger C, et al: Osteopontin is upregulated during in vivo demyelination and remyelination and enhances myelin formation in vitro. Mol...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 67
Published: 15 February 2011
10.1159/000325574
EISBN: 978-3-8055-9587-2
... of intestinal proliferation and differentiation and facilitating iron absorption, but these activities may have been limited due to earlier contamination with LPS. Lactoferrin free of lipopolysaccharide may prove to be more effective with regard to exerting these activities. Osteopontin is a heavily...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 90
Published: 13 March 2019
EISBN: 978-3-318-06341-7
... of osteopontin in human milk, bovine milk, and infant formulas. J Dairy Sci 2009;92:5378-5385. 15. Liao Y, Alvarado R, Phinney B, et al: Proteomic characterization of human milk whey proteins during a twelve-month lactation period. J Proteome Res 2011;10:1746-1754. 16. Liao Y, Alvarado R, Phinney B...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 67
Published: 15 February 2011
EISBN: 978-3-8055-9587-2
...-onset sepsis in very low-birth-weight neonates. JAMA 2009;302:1421-1428 27. Sodek J, Ganss B, McKee MD: Osteopontin. Crit Rev Oral Biol Med 200;11:279-303 28. Christensen B, Nielsen MS, Haselmann KF, et al: Post-translationally modified residues of native human osteopontin are located...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 86
Published: 28 June 2016
10.1159/000442729
EISBN: 978-3-318-05483-5
... examples of proteins that are resistant against proteolytic degradation in the gut. Together, these proteins serve protective roles against infection and support immune function in the immature infant. α-lactalbumin, β-casein, κ-casein and osteopontin are examples of proteins that are partially digested...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 90
Published: 13 March 2019
10.1159/000490484
EISBN: 978-3-318-06341-7
... of these proteins have physiological activities, and since some of their bovine counterparts are available commercially, they can be added to infant formula. She then presented studies in piglets and in infants that have evaluated the effects of adding lactoferrin, osteopontin, and MFGM to formula. In piglets...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 86
Published: 28 June 2016
EISBN: 978-3-318-05483-5
... pylori adhesion to human gastric mucosa. J Pediatr Gastroenterol Nutr 1995;21:288-296. 24. Sodek J, Ganss B, McKee MD: Osteopontin. Crit Rev Oral Biol Med 2000;11:279-303. 25. Christensen B, Nielsen MS, Haselmann KF, et al: Post-translationally modified residues of native human osteopontin...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 90
Published: 13 March 2019
10.1159/000490298
EISBN: 978-3-318-06341-7
... fat globule membrane. HM is whey predominant; however, the whey/casein ratio of HM changes from 90/10 in colostrum to 60/40 in mature HM. The whey proteins present in significant quantities in the whey fraction are α-lactalbumin, lactoferrin, IgA, osteopontin, and lysozyme. Additionally, bioactive...
Book Chapter
Series: Contributions to Nephrology
Volume: 169
Published: 14 January 2011
10.1159/000313951
EISBN: 978-3-8055-9538-4
...), gremlin, osteopontin, hydroxysteroid dehydrogenase- 3β isotype 4 and those of the Wnt signaling pathway, were identified as differentially expressed genes in kidneys of diabetic rodents. Functional analysis of these genes and the subsequent translational research in the clinical settings would be very...
Book Chapter
Series: Contributions to Nephrology
Volume: 169
Published: 14 January 2011
10.1159/000314578
EISBN: 978-3-8055-9538-4
... oxygen species, and catalase), hypoxic response (HIF- α), epithelial-mesenchymal transformation (e.g. hepatocyte growth factor, bone morphogenic protein 7 and nestin), and the upregulation of cytokines and growth factors (e.g. TGFβ-1, EGF, PDGF, VEGF and TNF-α) as well as chemokines (MCP-1, osteopontin...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 122
Published: 03 September 2021
EISBN: 978-3-318-06647-0
... AS, Peerson JM, Donovan SM, Peng YM, Lonnerdal B. Effects of osteopontin-enriched formula on lymphocyte subsets in the first 6 months of life: a randomized controlled trial. Pediatr Res 2017;82:63–71. 55. Albertsson AM, Zhang X, Leavenworth J, Bi D, Nair S, Qiao L, Hagberg H, Mallard C, Cantor H, Wang X...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 122
Published: 03 September 2021
10.1159/000514747
EISBN: 978-3-318-06647-0
..., and probiotics, which are discussed in a dedicated paper. Other bioactive components that are studied in term infants include osteopontin and α-lactalbumin. Osteopontin may improve immune function, and some effects on T cells were observed in a recent RCT in term infants [ 54 ]. Furthermore, osteopontin has been...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 96
Published: 30 June 2022
10.1159/000519401
EISBN: 978-3-318-07015-6
... cytokines, dendritic cells, T cells, and B cells [ 29 ]. Osteopontin is present in most human tissues and fluids but is most abundant in human milk. Osteopontin is involved in several biological functions including bone remodeling, inhibiting calcification of soft tissues, and plays an important role...
Book Chapter
Series: Contributions to Nephrology
Volume: 191
Published: 18 September 2017
EISBN: 978-3-318-06117-8
.... 30. Chen NX, O'Neill KD, Duan D, et al: Phosphorus and uremic serum up-regulate osteopontin expression in vascular smooth muscle cells. Kidney Int 2002;62:1724-1731. 31. Komaba H, Fukagawa M: Phosphate - a poison for humans? Kidney Int 2016;90:753-763. 32. Lau WL, Pai A, Moe SM, Giachelli CM...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 94
Published: 09 June 2020
10.1159/000505551
EISBN: 978-3-318-06685-2
... the protein osteopontin (OPN), which is abundant in breast milk, but low in cow milk and infant formula. OPN is involved in cell proliferation and differentiation, biomineralization, immunomodulatory activities, and myelination. They described studies in mouse pups receiving milk from wild-type and OPN...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 94
Published: 09 June 2020
10.1159/000505372
EISBN: 978-3-318-06685-2
... of lactoferrin, osteopontin, and effects of other proteins and antibodies on the mucosal microflora in breastfed infants. These areas of milk protective factors will be discussed by Lars Bode , Franz-Georg Hanisch and Cem Aydogan , Olle Hernell et al. , Nicholas D. Embleton and Jannet E. Berrington...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 99
Published: 21 October 2013
EISBN: 978-3-318-02481-4
... protein in angiogenesis. Allergy 2009;64:368-374. 72. O'Regan A: The role of osteopontin in lung disease. Cytokine Growth Factor Rev 2003;14:479-488. 73. Kohan M, Bader R, Puxeddu I, Levi-Schaffer F, Breuer R, Berkman N: Enhanced osteopontin expression in a murine model of allergen-induced airway...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 96
Published: 30 June 2022
EISBN: 978-3-318-07015-6
.... 31. Schack L, Lange A, Kelsen J, et al. Considerable variation in the concentration of osteopontin in human milk, bovine milk, and infant formulas. J Diet Sci. 2009;92(11):578–85. 32. Giuffrida F, Cruz-Hernandez C, Bertschy E, et al. Temporal changes of human breast milk lipids of Chinese...
Book Chapter
Series: Monographs in Oral Science
Volume: 29
Published: 12 January 2021
EISBN: 978-3-318-06852-8
..., Raarup MK, Wejse PL, Nyvad B, Stadler BM, Sutherland DS, et al: Osteopontin reduces biofilm formation in a multi-species model of dental biofilm. PLoS One 2012;7:e41534. 16. Oettinger-Barak O, Dashper S, Catmull D, Adams G, Sela M, Machtei E, et al: Antibiotic susceptibility of Aggregatibacter...