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ortholog

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Book Chapter
Series: Genome Dynamics
Volume: 2
Published: 24 July 2006
10.1159/000095104
EISBN: 978-3-318-01376-4
... the zebrafish genome. Principles of zebrafish genomic analysis, including gene mapping,ortholog identification, conservation of syntenies, genome duplication, and evolution ofduplicate gene function are discussed here using as a case study the zebrafish msxa, msxb, msxc,msxd, and msxe genes, which together...
Book Chapter
Series: Monographs in Human Genetics
Volume: 15
Published: 15 May 2007
10.1159/000102556
EISBN: 978-3-318-01461-7
... Abstract Orthologs of the human Fanconi anemia (FANC) genes have been identified in severalvertebrate and invertebrate model organisms, indicating variously conserved functions of theFANC protein complex. In particular, the analysis of chicken DT40 cells has made importantcontributions...
Book Chapter
Series: Genome Dynamics
Volume: 4
Published: 14 April 2008
10.1159/000126005
EISBN: 978-3-8055-8492-0
... Abstract Advances in the construction of large insert libraries and physical maps have facilitatedthe sequencing of orthologous regions from related plant species that differ in genome size.This approach has been particularly productive for the Poaceae, including many importantcereal crops...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 5
Published: 22 December 2014
10.1159/000366571
EISBN: 978-3-318-02732-7
... and Sesn3) in mammals but one ortholog in Drosophila . Sesns are regulated by many stress insults including DNA damage, oxidative stress, hypoxia, growth factor deprivation, hyperactive TOR and RAS signaling via p53 and FOXOs, and result in enhanced autophagy, reactive oxygen species reduction, reduced...
Book Chapter
Series: Developments in Biologicals
Volume: 132
Published: 08 August 2008
10.1159/000317150
EISBN: 978-3-8055-9596-4
... orthologous to the DE genes were collected and TFM-Explorer was used to identify a set of 72 gene promoters with significant over-representation of NF-ĸB DNA-binding motifs. All 22 known NF-ĸB target genes are in this list; we hypothesize that the remaining 51 genes are un-recognized NF-ĸB targets...
Book Chapter
Series: Genome Dynamics
Volume: 2
Published: 24 July 2006
10.1159/000095102
EISBN: 978-3-318-01376-4
..., extreme gene density, rapid molecular evolution and chromosomestability are some of the characteristics of the Tetraodon genome. The organization ofparalogous and orthologous genes in the genome have been key elements to prove that awhole genome duplication has occurred at the root of the teleost lineage...
Book Chapter
Series: Genome Dynamics
Volume: 2
Published: 24 July 2006
10.1159/000095103
EISBN: 978-3-318-01376-4
... comparable to that betweenhumans and rodents, and the current genome project is showing that their genome organizationis well conserved. Comparison of genome structure among teleosts and mammals helpsour understanding of the orthologous gene structure and the evolution of gene families invertebrates...
Book Chapter
Series: Contributions to Nephrology
Volume: 183
Published: 16 May 2014
10.1159/000360123
EISBN: 978-3-318-02651-1
... , 42 ], HIV-associated nephropathy [ 40 ], and hypertensive nephropathy [ 43 ] in individuals of African descent. APOL1 is expressed in human podocytes, but interestingly the mouse does not express an APOL1 ortholog [ 44 ]. In fact, despite significant similarities shared by human and mouse genome...
Book
Book Cover Image
Series: Genome Dynamics
Volume: 2
Published: 24 July 2006
10.1159/isbn.978-3-318-01376-4
EISBN: 978-3-318-01376-4
Book
Book Cover Image
Series: Genome Dynamics
Volume: 4
Published: 14 April 2008
10.1159/isbn.978-3-8055-8492-0
EISBN: 978-3-8055-8492-0
Book Chapter
Series: Genome Dynamics
Volume: 6
Published: 27 August 2009
10.1159/000235769
EISBN: 978-3-8055-9193-5
...% to 38.8%, and a noteworthy low coding density of 72.3% to 81.6% ( table 1 ). The chromosome sizes range from 1,445 kb (encoding 1,283 genes) for B. bacilliformis to 2,619 kb (encoding 2,136 genes) for B. tribocorum ( table 1 , fig. 2 ). Orthologous gene assignments resulted in the identification...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 40
Published: 09 October 2014
10.1159/000364930
EISBN: 978-3-318-02730-3
... of organisms like D. melanogaster for the genomic sites that affect aging [cf. [ 21 ]]. Furthermore, it is then straightforward to use orthology to identify corresponding loci in other outbred mendelian species that affect aging or chronic disease in those species. figure 2 provides a schematic...
Book Chapter
Series: Contributions to Nephrology
Volume: 183
Published: 16 May 2014
EISBN: 978-3-318-02651-1
..., Garcia-Lopez A, Artero R, Wilsch-Brauninger M, Ruiz-Gomez M, Skaer H, Denholm B: The insect nephrocyte is a podocyte-like cell with a filtration slit diaphragm. Nature 2009;457:322-326. 28. Zhuang S, Shao H, Guo F, Trimble R, Pearce E, Abmayr SM: Sns and Kirre, the Drosophila orthologs of Nephrin...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 1
Published: 22 April 2010
10.1159/000312651
EISBN: 978-3-8055-9244-4
... implicated in generating aging phenotypes [ 41 – 43 ]. In Caenorhabditis elegans , it has been shown that increased expression of the SIR2 ortholog, sir-2.1, increases lifespan by up to 50% [ 43 ]. Similarly, in Drosophila the activation of the SIRT2 ortholog increases lifespan [ 44 ]. Sirtuins have...
Book Chapter
Series: Contributions to Nephrology
Volume: 183
Published: 16 May 2014
EISBN: 978-3-318-02651-1
...:e1000112. 46. Liao BY, Zhang J: Null mutations in human and mouse orthologs frequently result in different phenotypes. Proc Natl Acad Sci USA 2008;105:6987-6992. 47. Ju W, et al: Defining cell-type specificity at the transcriptional level in human disease. Genome Res 2013;23:1862-1873. 48...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 1
Published: 22 April 2010
EISBN: 978-3-8055-9244-4
...: The human Sir2 ortholog, SIRT2, is an NAD + -dependent tubulin deacetylase. Mol Cell 2003;11:437-444 39. Frye RA: Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys...
Book Chapter
Series: Monographs in Human Genetics
Volume: 20
Published: 26 April 2016
EISBN: 978-3-318-05856-7
... L, Zhao F, Guan L, et al: A novel DFNA36 mutation in TMC1 orthologous to the Beethoven (Bth) mouse associated with autosomal dominant hearing loss in a Chinese family. PLoS One 2014;9:e97064. 45. Lentz JJ, Jodelka FM, Hinrich AJ, McCaffrey KE, Farris HE, et al: Rescue of hearing...
Book Chapter
Series: Genome Dynamics
Volume: 6
Published: 27 August 2009
10.1159/000235760
EISBN: 978-3-8055-9193-5
... in an exemplar genome for each functional role in the subsystem. These known genes are then analyzed in the SEED environment, which provides one-click tools to compare chromosomal regions surrounding a focus gene, to align and build a phylo-genetic tree of selected orthologs, and to locate chromosomal clusters...
Book Chapter
Series: Karger eBooks Non-Series Collection
Published: 02 June 2015
EISBN: 978-3-318-03004-4
...: England and Wales 1989-2009. Am J Med Genet A 2012;158A:1151-1157. 10. Sturgeon X, Gardiner KJ: Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions. Mamm Genome 2011;22:261-271. 11. Lana-Elola E, Watson-Scales SD, Fisher EM, Tybulewicz VL: Down syndrome...
Book
Book Cover Image
Series: Genome Dynamics
Volume: 3
Published: 13 September 2007
10.1159/isbn.978-3-8055-8341-1
EISBN: 978-3-8055-8341-1