Search Results for ocular

... conditions includes eye metastases, advanced glaucoma, age-related macular degeneration, hemangioblastoma, pseudotumors, and vegetative pain. Radiosurgery of ocular disorders depends on close cooperation with ophthalmologists who are decisive in determining whether radiosurgery is indicated and in the follow...

... Abstract There is a large body of evidence from clinical and experimental studies indicating that the long-term use of topical drugs may induce ocular surface changes, causing ocular discomfort, dry eye, conjunctival inflammation, subconjunctival fibrosis, corneal surface impairment...

... in axial elongation after cataract extraction, the magnitude of this effect is much less than what has been reported in animal models. Choosing an intraocular lens (IOL) power for implantation into a child's eye is complicated by continued ocular growth, the inaccuracy of IOL power calculation formulas...

... of the lacrimal drainage system, contaminated eye drops, contact lens wear, a contralateral ocular prosthesis and active infection elsewhere in the body. Intraoperative risk factors include prolonged surgery, secondary IOL implantation, posterior capsular rupture, vitreous loss, iris prolapse, contaminated...

... Abstract Systematic study of the mechanisms underlying pathological ocular neovascularization has yielded a wealth of knowledge about pro- and anti-angiogenic factors that modulate diseases such as neovascular age-related macular degeneration. The evidence implicating vascular endothelial...

... for understanding pharmacotherapeutics that may be useful in treating retinal disease. History Like the field of immunology, the field of ocular immunology and inflammation has grown rapidly over the past years. This chapter covers broad concepts in immunology important in ocular disease as well as basic...

... Abstract Hydrogel as an ocular drug delivery platform holds great potential. Hydrogels are three-dimensional, hydrophilic, polymeric networks capable of absorbing large amounts of water or biological fluids. They have the ability to swell in an aqueous solvent system, holding solvents within...

..., the suppression was greater than that achieved with anti-VEGF DARPin alone. Similarly, strong suppression of retinal NV was also achieved with 1.85 µg of anti-PDGF-BB DARPin. These findings suggest that PDGF is a valid target for the treatment of ocular NV. Several clinical trials evaluating the role of PDGF...

... Abstract Ocular gene therapy involves the introduction of an exogenous gene product to a host's cellular and genetic machinery for endogenous production of a desired gene product. The eye represents an ideal target organ due to its easy visibility and accessibility, and several trials have...

... Abstract The ocular surface (OS) is a functional unit comprising the eyelids and blink reflexes, tear film and tear glands, the conjunctival mucus membrane and substantia propria, and the corneal epithelium and Bowman's zone. Its health is crucial for vision. The OS can be affected by a variety...

... Abstract Ocular ischemic syndrome (OIS) is caused by reduction of global blood flow to the eye. OIS is usually related to unilateral or bilateral atherosclerotic disease of the internal carotid artery, which can produce anterior and/or posterior segment ischemia, leading to neovascularization...

... Abstract There is a large body of evidence from clinical and experimental studies that the long-term use of topical drugs may induce ocular surface changes, causing ocular discomfort, dry eye, conjunctival inflammation, subconjunctival fibrosis, corneal surface impairment, and, as a consequence...

... Abstract Angiogenesis is defined as the formation of new blood vessels from the existing vasculature. It is a highly coordinated process occurring during development of the retinal vasculature, ocular wound healing, and in pathological conditions. Complex interactions are involved between non...

... to be in enhancing wound healing by promoting a process called ‘restitution’. Studies evaluating TFF3 properties and effects at the ocular surface using in vivo as well as in vitro models have revealed a pivotal role of TFF3 in corneal wound healing. Subsequent studies in osteoarthritic cartilage seem to draw...

... Abstract The ocular surface is in constant contact with the environment (e.g. when using one’s fingers to insert a contact lens) and thus also with diverse bacteria, bacterial components and their pathogen associated molecules. Dysfunctions of the tear film structure or decreased moistening...

... Abstract Purpose: The structure of the lid margin is insufficiently understood and defined, although it is of obvious importance in ocular surface integrity. Methods: The structure and function of the different zones of the lid margin are explained with a focus on dry eye disease. Results...