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Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338368
EISBN: 978-3-318-02184-4
... Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, decrease mucosal prostaglandin (PG) E 2 content by inhibiting cyclooxygenase (COX) activity and cause damage in the small intestine. The development of these lesions required the inhibition of both COX-1 and COX-2...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338380
EISBN: 978-3-318-02184-4
... Abstract Nonsteroidal anti-inflammatory drugs (NSAID) are the most commonly prescribed drugs for arthritis, inflammation, and cardiovascular protection. However, they often cause gastrointestinal complications such as gastric ulcers and erosions. The pathophysiology of these complications has...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338398
EISBN: 978-3-318-02184-4
... Abstract Although extensive studies have been performed on the cellular and molecular aspects pathogenesis of gastrointestinal (GI) injury from non-steroidal anti-inflammatory drugs (NSAIDs), there has been relatively little attention to the chemical features of these drugs which cause cellular...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338396
EISBN: 978-3-318-02184-4
... Abstract The anti-inflammatory action of nonsteroidal anti-inflammatory drugs (NSAIDs) is mediated through their inhibitory effects on cyclooxygenase (COX) activity. On the other hand, NSAIDs use is associated with gastrointestinal complications. The inhibition of COX by NSAIDs is not the sole...
Book Chapter
Published: 31 May 2007
10.1159/000104211
EISBN: 978-3-318-01454-9
... hypersensitivity reactions to aspirin are elicited viainhibition of cyclooxygenase-1 by NSAIDs. These two syndromes,cared for by different specialists, are characterizedat the biochemical level by profound alterations in eicosanoidbiosynthesis, best exemplified by cysteinyl leukotrieneoverproduction. They should...
Book Chapter
Book Chapter
Book Chapter
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338377
EISBN: 978-3-318-02184-4
... Abstract In humans, nonsteroidal anti-inflammatory drugs (NSAIDs) cause mucosal damage in the small intestine as well as in the stomach and duodenum. Gastric and duodenal lesions caused by NSAIDs can be effectively treated with antisecretory agents; however, there are few effective agents...
Book Chapter
Book Chapter
Series: Developments in Ophthalmology
Volume: 55
Published: 27 October 2015
10.1159/000431197
EISBN: 978-3-318-05565-8
... Abstract Nonsteroidal anti-inflammatory drugs (NSAIDs) are an important class of drugs in medicine and ophthalmology. Several NSAIDs have been commercially available for many years: diclofenac, flurbiprofen, indomethacin, ketorolac and suprofen. The purpose of this chapter is to review...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 32
Published: 23 September 2013
10.1159/000350629
EISBN: 978-3-318-02416-6
... Abstract Clinicians prescribing nonsteroidal anti-inflammatory drugs (NSAIDs) are challenged with two problems: (1) selection of nonselective traditional NSAIDs or cyclooxygenase-2 inhibitors, and (2) choice of suitable strategies to prevent the recurrence of drug-induced gastroduodenal injury...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 95
Published: 02 June 2010
10.1159/000315950
EISBN: 978-3-8055-9442-4
... Abstract Aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) are often incriminated in hypersensitivity reactions leading to anaphylaxis. Two populations are at the high risk of developing such reactions: patients with asthma and those with urticaria. In a subset of asthmatics...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338414
EISBN: 978-3-318-02184-4
... Abstract Nitric oxide (NO) has a variety of actions in inflammation, haemostasis and thrombosis, including the potential to reduce the local toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) in the gastro-intestinal tract. NO-donating non-steroidal anti-inflammatory drugs (NO-NSAIDs...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 100
Published: 27 May 2014
10.1159/000358618
EISBN: 978-3-318-02195-0
...-steroidal anti-inflammatory drugs (NSAIDs) are, after β-lactam antibiotics, the second most common cause of drug hypersensitivity. Natural salicylates such as salicin and salicylic acid are present in the bark and leaves of willow and poplar trees, and these compounds constitute the ancestry to aspirin...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 32
Published: 23 September 2013
EISBN: 978-3-318-02416-6
.... Musumba C, Pritchard DM, Pirmohamed M: Review article: cellular and molecular mechanisms of NSAID-induced peptic ulcers. Aliment Pharmacol Ther 2009;30:517-531. 3. Flower R, Gryglewski R, Herbaczynska-Cedro K, Vane JR: Effects of anti-inflammatory drugs on prostaglandin biosynthesis. Nat New Biol...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
EISBN: 978-3-318-02184-4
...References References 1. Graham DY, Opekum AR, Willingham FF, Qureshi WA: Visible small-intestinal mucosal injury in chronic NSAID users. Clin Gastroenterol Hepatol 2005;3:55-59 2. Maiden L, Thjodleifsson B, Theodors A, Gonzalez J, Bjarnason I: A quantitative analysis of NSAID-induced...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
EISBN: 978-3-318-02184-4
...References References 1. Rainsford KD: The ever-emerging anti-inflammatories. Have there been any real advances?. J Physiol (Paris) 2001;95:11-19 2. Bjarnason I, Scarpignato C, Rainsford KD: Determinants of the short-term gastric damage caused by NSAIDs in man. Aliment Pharmacol Therap...
Book Chapter
Series: Modern Trends in Psychiatry
Volume: 31
Published: 02 August 2017
10.1159/000470814
EISBN: 978-3-318-06051-5
... of anti-inflammatory drugs under the perspective of current pharmacological and neurophysiological data. This evaluation included the use of nonsteroidal anti-inflammatory drugs (NSAIDs) as adjunctive treatment to conventional pharmacotherapy as well as the use of natural products exerting anti...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 79
Published: 03 August 2016
10.1159/000445093
EISBN: 978-3-318-05854-3
... Abstract Aspirin exacerbated respiratory disease (AERD) has been defined as a non-steroidal anti-inflammatory drug (NSAID)-triggered hypersensitivity, non-allergic bronchial asthma and chronic rhinosinusitis (CRS) with nasal polyps. The underlying pathophysiology of AERD is not completely...