... granulations. A subset of chronic communicating hydrocephalus found in the elderly is known as ‘normal pressure hydrocephalus', or NPH. NPH presents as a clinical triad of gait disturbance, dementia and incontinence [ 2, 3 ]. It is significant because it is one of the few treatable causes of dementia, treated...

... insulin available at that time, i.e. neutral protamine Hagedorn (NPH; given either isolated or admixed-premixed with rapid-acting insulin). The superiority of CSII in the NPH era was indisputable with lower mean blood glucose and less hypoglycemia as shown by several trials [ 11 ]. The ‘egg of Columbus...

... is required [ 23 , 24 ]. A general classification consists of long-acting insulin analogs (glargine, detemir, and degludec), intermediate-acting (neutral protamine Hagedorn [NPH]), short-acting (regular insulin), and rapid-acting analogs (lispro, aspart, and glulisine; Table 1 ). The insulin patterns may...

... to medullary nephronophthisis (NPH). Polycystic Disease in Adults and Children ADPKD is the most frequent hereditary cystic disease (5% of the dialysis population) and its clinical manifestations appear between 30 and 50 years [ 10 ]. All imaging techniques are sensitive in the diagnosis of ADPKD...

... of the glycemic control in diabetics. At present, 3 long-acting insulin analogs are available, with different structures and different PK and PD characteristics. Glargine (I-Gla) is a soluble long-acting insulin analog, peakless as compared to neutral protein Hagedorn (NPH), with duration of action around...

..., Filippi A, Burlina S, Lapolla A: Diabetic pregnancy outcomes in mothers treated with basal insulin lispro protamine suspension or NPH insulin: a multicenter retrospective Italian study. J Matern Fetal Neonatal Med 2016;29:1061–1065. 40. Colatrella A, Visalli N, Abbruzzese S, Leotta S, Bongiovanni M...

..., a lower insulin solubility when injected subcutaneously, and a capacity for dimerization, which give rise to a longer-lasting action, a more limited glucose variability, and a lower risk of nocturnal hypoglycemia by comparison with neutral protamine Hagedorn (NPH) insulin. The safety of glargine...

..., Bartocci L, Di Vincenzo A, Cordoni C, Costa E, Brunetti P, Bolli GB: Pharmacokinetics and pharmacodynamics of the long-acting human insulin analog glargine, NPH insulin, and ultralente human insulin injected subcutaneously, and continuous subcutaneous infusion of insulin lispro. Diabetes 2000;49:2142–214...

... with the use of insulin glargine versus NPH insulin during pregnancy. Obstet Gynecol Int 2012;2012:649070. 25. Lapolla A, DiCianni G, Bruttomesso D, Dalfrà MG, Fresa R, Mello G, Napoli A, Romanelli T, Sciacca L, Stefanelli G, Torlone E, Mannino D: Use of insulin detemir in pregnancy: a report on 10 type 1...

... insulin dose, such as neutral protamine Hagedorn (NPH), may be reduced 25-50% given its pharmacokinetic action and peak after 4 h of administration [ 16 ]. The pharmacokinetic profile of insulin types is illustrated in table 3 . Table 3 Pharmacokinetic profile of subcutaneous insulin...

..., Bolli GB: Superiority of insulin analogues versus human insulin in the treatment of diabetes mellitus. Arch Physiol Biochem 2008;114:3-10. 14. Heise T, Nosek L, Rønn BB, Endahl L, Heinemann L, Kapitza C, Draeger E: Lower within-subject variability of insulin detemir in comparison to NPH insulin...

.... Treatment is generally centered around a therapeutic trial of levodopa, with response seen in about a quarter of patients. An additional disorder that presents with gait dysfunction, sometimes comparable to that of Parkinsonism is normal pressure hydrocephalus (NPH), a condition characterized...

...: correlation of MR imaging and histopathologic findings. Radiology 1988;167:517-522. 3357964 10.1148/radiology.167.2.3357964 18. Bradley WG, Safar F, Furtado C, Ord J, Alksne J: Increased intracranial volume in normal pressure hydrocephalus: a clue to the etiology of ‘idiopathic' NPH? AJNR Am J...

... oral agents have also been studied. The basal insulin most frequently studied and used for women with GDM is neutral protamine Hagedorn (NPH) insulin. In women with type 1 diabetes, insulin detemir has been evaluated in a RCT published in 2012 and has been found to provide equal glycemic control...

... a stochastic model of health transitions between two fixed time points [ 16 ]. Fig. 1 A Examples of individual trajectories of the deficit count in 12 randomly selected participants of the NPHS. Individual trajectories are represented by dots connected by dashed lines. The age-specific deficit count...

... with gestational diabetes mellitus. Appl Nurs Res 2014;27:227-230. 42. Mathiesen ER, Hod M, Ivanisevic M, Duran Garcia S, Brondsted L, Jovanovic L, et al: Maternal efficacy and safety outcomes in a randomized, controlled trial comparing insulin detemir with NPH insulin in 310 pregnant women with type 1...