Search Results for novel

... the development of further antidepressant medications, including the tricyclic antidepressants and serotonin-specific reuptake inhibitors, both of which act to increase central monoamine levels. However, over the past 20 years, few new or novel antidepressants have emerged and the field of psychopharmacology...

.... In laboratory settings, repeated exposure is effective in promoting children’s acceptance and consumption of novel foods. We have recently explored mother and child early experiences (from infancy to toddlerhood) with offering hard-to-like foods. Our findings suggest a “sweet spot” for food introduction...

... The expansion of novel technologies has not yet translated into many new vaccines for older adults. Vaccines developed and licensed for use in older adults have to date relied on adaptations of established techniques to improve immunogenicity; primarily focusing on influenza vaccines (high-dose, adjuvanted...

... pressure, smoking and body mass index) from retinal photographs [ 22 , 23 ]. The aim of this chapter is to review (1) the use of computer-aided analysis on retinal vasculature; (2) AI on fundus photographs and; (3) OCT with and without angiography in the evaluation of systemic CVDs. Novel Computer-Aided...

... of current experimental MTT vary and may be systematized in any number of ways, but suffice it to say that inhibition of all characteristics of tumor survival, proliferation, apoptosis, invasion, and angiogenesis are under investigation. This chapter highlights novel molecular targets for therapy of gliomas...

... Abstract Preclinical mouse models that allow the evaluation of novel techniques in radiotherapy using charged particles like protons or heavier ions are discussed here. Focused beams of protons or carbon ions offer distinct physical characteristics that might contribute to an overall improved...

... anymore. What are the novel uses of fillers? The sky's the limit: off-label uses of fillers are possibly more common than their on-label uses. Fillers are used in fingers, hands, arms, cleavages, buttocks, knees, feet, noses, necks, temples, foreheads, glabellas, upper eyelids, eyebrows, under eye circles...

... following current conventional therapies. Given these extant problems, the development of novel therapies that directly target the pathogenic disease mechanisms in GO are essential to advance our treatment options and improve clinical outcomes. What Are the Targets for Potential...

... in the pathogenesis [ 2 ], and that the anti-PIT-1 antibody is not the cause but a marker of anti-PIT-1 antibody syndrome. This novel clinical entity termed ‘anti-PIT-1 antibody syndrome' was defined by (1) acquired CPHD characterized by specific GH, PRL, and TSH deficiencies; (2) the presence of circulating anti...

... of HNECs and found that miRNA-146a plays crucial roles in the maintenance of the TJ barrier and innate immune response against invading pathogens. This chapter reviews a novel drug delivery system across the nasal mucosa from the point of view of the epithelial barrier function. Intranasal insulin...

...: Enhancement of optical skin clearing efficacy using a microneedle roller. J Biomed Opt 2008;13:021103. 28. Henry S, McAllister DV, Allen MG, Prausnitz MR: Microfabricated microneedles: a novel approach to transdermal drug delivery. J Pharm Sci 1998;87:922-925. 29. Sklar LR1, Burnett CT, Waibel JS, Moy...

... Abstract This chapter deals with novel therapeutic approaches, predominantly for type 2 diabetes. Incretin-based therapies utilize the effects of glucagon-like peptide-1 (GLP-1), which stimulates insulin and inhibits glucagon secretion in a glucose-dependent manner. Incretin-based therapies...

...-wide information. To enable analysis of this information we and others are developing a variety of computational tools that allow bioinformaticists and wet laboratory biologists to extract novel patterns of data from these results and generate novel biological insights while generating new hypotheses...

... is associated with a high morbidity and mortality, and is available only to nearly asymptomatic X-ALD children [ 12 ]. This alternative treatment has the same indications as bone marrow transplantation, meaning that it can be applied only to a small subset of patients with few to no symptoms [ 13 ]. A novel...

.... This chapter focuses on the importance of novel biomarkers: microRNA and microRNA inhibitors; DNA methylation and epigenetics, and immunotherapy and virotherapy to develop novel treatments for NETs. Novel Biomarkers Our understanding of neuroendocrine tumor (NET) biology and treatments has changed...