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nkt
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Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324775
EISBN: 978-3-8055-9723-4
... Abstract Human NKT cells are known to have strong antitumor activities and to be activated by specific ligand, α-galactosylceramide (αGelCer). We examined the migration pattern of αGalCer-pulsed DCs and the immune responses after administration by different routes. DCs injected into nasal...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000154998
EISBN: 978-3-8055-8629-0
... and spleen. In the thymus, ocular-influenced monocytic cells activate natural killer T (NKT) cells that migrate to the spleen where, in concert with the ocular-influenced monocytic emigrants, they (ii) activate CD4+ and CD8+ immunoregulatory T cells. (iii) The generation of the CD8+ Tregs is dependent on NKT...
Book Chapter
Book: History of Allergy
Series: Chemical Immunology and Allergy
Volume: 100
Published: 27 May 2014
10.1159/000358622
EISBN: 978-3-318-02195-0
... Th17 and Th9 cells, as well as invariant NKT cells, have been implicated in the pathogenesis of allergic disorders, but their role is certainly more limited. Recently, innate lymphoid type 2 cells (ILC2) have been found to be able to produce high amounts of IL-5 and IL-13 in response to stimulation...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346527
EISBN: 978-3-318-02348-0
... immunobiology [ 3 , 4 ]. Toll-Like Receptor System in Ischemia/Reperfusion-Triggered Innate Immune Activation Figure 1 identifies the major players in the immune cascade of liver IRI, i.e. Kupffer cells (KCs), dendritic cells (DCs), neutrophils (PMNs), T cells and NK/NKT cells [ 4 ]. In the first...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
EISBN: 978-3-8055-9723-4
...References References 1. Schuler G, Schuler-Thurner B, Steinman RM: The use of dendritic cells in cancer immunotherapy. Curr Opin Immunol 2003;15:138-147 2. Taniguchi M, Harada M, Kojo S, Nakayama T, Wakao H: The regulatory role of Valpha14 NKT cells in innate and acquired immune response...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 5
Published: 04 July 2016
EISBN: 978-3-318-05867-3
... of autoimmunity. J Immunol 2012;189:1228-1236. 18. Jiang X, Kojo S, Harada M, Ohkohchi N, Taniguchi M, Seino KI: Mechanism of NKT cell-mediated transplant tolerance. Am J Transplant 2007;7:1482-1490. 19. Liu Y, Luan X, Li J, He Y, Li M: The role of invariant NKT cells in liver transplant tolerance in rats...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 38
Published: 18 January 2013
10.1159/000343596
EISBN: 978-3-318-02307-7
... virus or in vitro upon stimulation with influenza virus has been shown as well [ 9 ]. Innate Immune Responses Cumulative evidence indicates that aging exerts significant effects on all cells of the innate immune system [ 10 ]. This includes natural killer (NK) cells, natural killer T (NKT) cells...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 5
Published: 04 July 2016
10.1159/000444976
EISBN: 978-3-318-05867-3
... in humans. Generation of Tolerogenic Immune Cells Derived from iPSCs The tolerogenic immune cells such as regulatory T cells (Tregs), natural killer T (NKT) cells, tolerogenic dendritic cells (DCs), and regulatory B cells can modulate immunological rejection and prolong allograft survival, partially...
Book Chapter
Series: Contributions to Microbiology
Volume: 17
Published: 31 May 2011
10.1159/000324024
EISBN: 978-3-8055-9711-1
... including Th2 cells, T-regulatory cells (Tregs), natural killer T cells (NKT cells), macrophages, dendritic cells (DCs) and some subsets of B lymphocytes. IL-10 has a strong suppressive effect on many innate immune/pro-inflammatory cell types including monocytes/macrophages, dendritic cells, neutrophils...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
EISBN: 978-3-8055-9567-4
...: Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med 2003;9:(5)582-8 20. Lisbonne M, Diem S, de Castro, Keller A, et al: Cutting edge: Invariant V a 14 NKT cells are required for allergen-induced airway inflammation...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
EISBN: 978-3-8055-9723-4
...:2510-2516 2. Noda K, Kodama S, Umemoto S, Abe N, Hirano T, Suzuki M: Nasal vaccination with P6 outer membrane protein and a-galactosylceramide induces nontypeable Haemophilus influenzae-specifk protective immunity associated with NKT cell activation and dendritic cell expansion in nasopharynx...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 38
Published: 18 January 2013
EISBN: 978-3-318-02307-7
... immunity and aging. Exp Gerontol 2008;43:718-728 11. Ogata K, Yokose N, Tamura H, et al: Natural killer cells in the late decades of human life. Clin Immunol Immunopathol 1997;84:269-275 12. Mocchegiani E, Malavolta M: NK and NKT cell functions in immunosenescence. Aging Cell 2004;3:177-184 13...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320800
EISBN: 978-3-8055-9567-4
... of T-cell receptor activation. In addition to Th2 cells, invariant NKT (iNKT) cells were shown to be important mediators of airway hyperreactivity (AHR), a key feature of asthma. iNKT-deficient mice do not develop AHR and show reduced eosinophil infiltration in response to antigen ( 19 , 20...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 43
Published: 04 May 2020
EISBN: 978-3-318-06678-4
.... Cell Rep 2018;22:1276–1287. 68. Peralbo E, Alonso C, Solana R: Invariant NKT and NKT-like lymphocytes: two different T cell subsets that are differentially affected by ageing. Exp Gerontol 2007;42:703–708. 69. Vomhof-DeKrey EE, Yates J, Leadbetter EA: Invariant NKT cells provide innate...
Book Chapter
Book: Actinic Keratosis
Series: Current Problems in Dermatology
Volume: 46
Published: 22 December 2014
EISBN: 978-3-318-02763-1
..., Kabashima K: Regulatory T cells in cutaneous immune responses. J Dermatol Sci 2011;63:75-82. 6. Mattarollo SR, Yong M, Gosmann C, et al: NKT cells inhibit antigen-specific effector CD8 T cell induction to skin viral proteins. J Immunol 2011;187:1601-1608. 7. Goubier A, Vocanson M, Macari C, et al...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 97
Published: 12 May 2023
EISBN: 978-3-318-07170-2
... of human milk oligosaccharides, breastmilk microbiome and infant gut microbiome are associated with maternal characteristics. Int J Food Sci Technol. 2022;57:2793–807. 11. Mattner J, DeBord KL, Ismail N, et al. Exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
EISBN: 978-3-8055-9567-4
...References References 1. Wills-Karp M: Interleukin 13 in asthma pathogenesis. Immunol Rev 2004;202:175-90 2. Akbari O, Stock P, Meyer E, et al: Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity. Nat Med 2003;9:(5)582-8 3...
Book
Published: 14 September 2000
10.1159/isbn.978-3-318-00599-8
EISBN: 978-3-318-00599-8
Book Chapter
Series: Contributions to Microbiology
Volume: 17
Published: 31 May 2011
EISBN: 978-3-8055-9711-1
... effector TH17 and regulatory T cells. Nature 2006;441:235-238 20. Hu CK, Venet F, Heffernan DS, et al: The role of hepatic invariant NKT cells in systemic/local inflammation and mortality during polymicrobial septic shock. J Immunol 2009;182:2467-2475 21. Chung CS, Watkins L, Funches A, Lomas-Neira...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 43
Published: 04 May 2020
10.1159/000504479
EISBN: 978-3-318-06678-4
... that B cells carry pattern recognition receptors and can respond to antigens without the aid of Tfh cells. They can also receive stimuli from many different types of cells such as natural killer (NK) cells, CD1d-restricted iNKT, NKT-like lymphocytes [ 68 , 69 ] and mucosal-associated invariant T cells...
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