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Book Chapter
Series: Contributions to Nephrology
Volume: 178
Published: 30 May 2012
10.1159/000337888
EISBN: 978-3-318-02163-9
... Abstract Neutrophil gelatinase-associated lipocalin (NGAL), a protein involved in iron handling, has been recognized as a marker of inflammation. In this regard, serum and urine NGAL levels have proven a useful diagnostic tool for acute kidney injury. Bacterial peritonitis is an all too common...
Book Chapter
Series: Contributions to Nephrology
Volume: 164
Published: 05 May 2010
10.1159/000313725
EISBN: 978-3-8055-9417-2
... such as NGAL or cystatin C may become altered well before creatinine or oliguria signal a condition of reduced kidney function. Here, the difference between insult and dysfunction becomes evident. Novel biomarkers seem to enable the clinician to make early diagnosis of kidney damage, distinguishing between AKI...
Book Chapter
Series: Contributions to Nephrology
Volume: 193
Published: 08 February 2018
10.1159/000484960
EISBN: 978-3-318-06311-0
... gelatinase-associated lipocalin (NGAL) has been extensively examined as a renal injury biomarker under a range of conditions. For example, urinary and plasma NGAL predicting AKI after cardiopulmonary bypass has been studied in over 1,000 adults and over 300 children. In children, urinary and plasma NGAL...
Book Chapter
Series: Contributions to Nephrology
Volume: 164
Published: 05 May 2010
EISBN: 978-3-8055-9417-2
... gelatinase-associated lipocalin (NGAL): a novel urinary biomarker for cisplatin nephrotoxicity. Am J Nephrol 2004;24:307-315 20. Supavekin S, Zhang W, Kucherlapati R, Kaskel FJ, Moore LC, Devarajan P: Differential gene expression following early renal ischemia-reperfusion. Kidney Int 2003;63:1714-1724...
Book Chapter
Series: Contributions to Nephrology
Volume: 165
Published: 04 May 2010
10.1159/000313768
EISBN: 978-3-8055-9473-8
... such as neutrophil gelatinase-associated lipocalin (NGAL), hepatocyte growth factor (HGF), epidermal growth factor, and insulin-like growth factor-1, etc., play a major role in the recovery process. Such findings provide a great opportunity to test and validate these potential biomarkers as candidate markers...
Book Chapter
Series: Contributions to Nephrology
Volume: 182
Published: 14 May 2013
10.1159/000349963
EISBN: 978-3-318-02407-4
... criteria for diagnosis of AKI. Adding injury biomarkers as a criterion for AKI will complement the ability of RIFLE/AKIN to define AKI. Promising diagnostic injury markers include neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule 1 (KIM-1), interleukin 18 (IL-18) and liver-type...
Book Chapter
Series: Contributions to Nephrology
Volume: 165
Published: 04 May 2010
10.1159/000313748
EISBN: 978-3-8055-9473-8
..., a rapid diagnosis of AKI leads to stop the progressive kidney damage on the basis of an appropriate therapeutic approach. Recent studies have demonstrated that by using a new biomarker, neutrophil gelatinase-associated lipocalin (NGAL), it is possible to obtain an accurate and fast diagnosis of AKI...
Book Chapter
Series: Contributions to Nephrology
Volume: 160
Published: 19 May 2008
10.1159/000125893
EISBN: 978-3-8055-8545-3
...(NGAL and cystatin C) and urine (NGAL, KIM-1, IL-18, cystatin C, ∝1-microglobulin,fetuin-A, Gro-∝, and meprin) for the investigation of AKI. It is likely that the AKI panels willbe useful for timing the initial insult and assessing the duration of AKI. Based on the differentialexpression...
Book Chapter
Series: Contributions to Nephrology
Volume: 156
Published: 10 May 2007
10.1159/000102085
EISBN: 978-3-318-01456-3
... biomarkers that have recently emerged through the application of innovativetechnologies such as functional genomics and proteomics to human and animal modelsof AKI. Results: The most promising biomarkers of AKI for clinical use include a plasmapanel (NGAL and cystatin C) and a urine panel (NGAL, Il-18...
Book Chapter
Series: Contributions to Nephrology
Volume: 182
Published: 14 May 2013
10.1159/000349969
EISBN: 978-3-318-02407-4
... embolism; SVR = systemic vascular resistance; HF = heart failure; CKD = chronic kidney disease; RAS = renal artery stenosis; GFR = glomerular filtration rate; NGAL = neutrophil gelatinase-associated lipocalin; IL-18 = interleukin-18; KIM-1 = kidney injury molecule 1; L-FABP = liver-type fatty acid binding...
Book Chapter
Series: Contributions to Nephrology
Volume: 182
Published: 14 May 2013
10.1159/000349964
EISBN: 978-3-318-02407-4
... of using urinary NGAL to distinguish pre-renal from intrinsic AKI, the investigators were able to classify the pre-renal versus intrinsic renal state based on fluid responsiveness in only 25% of cases [ 13 ]. Furthermore, the notion that aggressive fluid resuscitation leads to improved renal perfusion...
Book Chapter
Series: Contributions to Nephrology
Volume: 182
Published: 14 May 2013
10.1159/000349965
EISBN: 978-3-318-02407-4
..., and in the ICU settings where multiple insults combine to lead to AKI. For example, in the setting of pediatric cardiac surgery, early postoperative elevations in urinary interleukin (IL)-18, and urinary and plasma neutrophil gelatinase-associated lipocalin (NGAL) were all significantly associated with longer...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500379
EISBN: 978-3-318-06540-4
... of the disease. Neutrophil Gelatinase-Associated Lipocalin in Leptospirosis-Associated AKI Many studies have explored the role of biomarkers to predict the development of AKI. One of the most robust biomarkers for AKI is neutrophil gelatinase-associated lipocalin (NGAL). It has been extensively studied...
Book Chapter
Series: Contributions to Nephrology
Volume: 165
Published: 04 May 2010
10.1159/000313747
EISBN: 978-3-8055-9473-8
... accurate risk stratification of patients with acute HF or ACS [ 18 , 19 ]. Neutrophil Gelatinase-Associated Lipocalin Neutrophil gelatinase-associated lipocalin (NGAL), a 25-kDa protein of lipoc-alin superfamily, is emerging as one of the most promising biomarkers for AKI. It is expressed...
Book Chapter
Series: Contributions to Nephrology
Volume: 178
Published: 30 May 2012
EISBN: 978-3-318-02163-9
...:165-174 3. Bolignano D, Donato V, Coppolino G: , et al Neutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney damage. Am J Kidney Dis 2008;52:595-605 4. Devarajan P: Biomarkers for the early detection of acute kidney injury. Curr Opin Pediatr 2011;23:194-200 5. Aroeira LS...
Book Chapter
Series: Contributions to Nephrology
Volume: 199
Published: 17 December 2021
10.1159/000517703
EISBN: 978-3-318-06937-2
... with an increase in albuminuria, corroborating its potential role as a marker of nephropathy in SCD. Neutrophil gelatinase-associated lipocalin (NGAL), also called lipocalin-2, has been studied as a new marker of kidney injury, both in animal models and in clinical studies. It is a glycoprotein linked...
Book Chapter
Series: Contributions to Nephrology
Volume: 165
Published: 04 May 2010
10.1159/000313741
EISBN: 978-3-8055-9473-8
... characteristics including duration of CPB and in hemodynamic and fluid management during and after cardiac surgery, nor in plasma creatinine, plasma urea or urinary neutrophil gelatinase-associated lipocalin (NGAL). The mean dose of sodium bicarbonate was 307 ± 57 mmol and the mean dose of sodium chloride was 309...
Book Chapter
Series: Contributions to Nephrology
Volume: 164
Published: 05 May 2010
10.1159/000313724
EISBN: 978-3-8055-9417-2
.... A biomarker that rapidly increases with acute kidney injury could prove to be very powerful in guiding therapy in these complex clinical scenarios. Biology Neutrophil gelatinase-associated lipocalin (NGAL) is a small 25-kDa molecule that belongs to a superfamily of lipocalins, and is normally secreted...
Book Chapter
Series: Contributions to Nephrology
Volume: 165
Published: 04 May 2010
10.1159/000313776
EISBN: 978-3-8055-9473-8
... diagnosis. In this respect, neutrophil gelatinase-associated lipocalin (NGAL) is one that has received the most attention in the past year. Human NGAL is a 25-kDa protein covalently bound to gelatinase, and is one of the most upregulated transcripts in the kidney very early after acute injury. The NGAL Meta...
Book Chapter
Series: Contributions to Nephrology
Volume: 174
Published: 15 September 2011
10.1159/000329230
EISBN: 978-3-8055-9811-8
... infiltration in the generation of AKI. Because creatinine elevation is delayed from renal injury, early detection might help in deciding on the therapeutic strategy. To achieve such a goal, the development of biomarkers for renal injury might be helpful. Some molecules such as NGAL, kidney injury molecule-1...