.... The term “neuroprotection” is attractive clinically and may involve different mechanisms. Many causative and protective factors of neurodegeneration and neuroregeneration have been proposed. However, the specificity of these factors and agents and differential neuronal vulnerability factors have generally...

... Abstract Neuronal death is the primary cause of vision loss in most retinal diseases. Neuroprotection is the modification of neurons, and/or their surrounding environment, to promote the survival and function of the neurons, especially in environments that would normally be deleterious...

...-associated peptides. AD pathogenic factors may therefore induce neurodegeneration by decreasing in nerve cells endogenous production of neuroprotective neurosteroids. The technological approach used herein appears as a promising strategy to get valuable insights into the clarification of pathophysiological...

... mechanisms for maintenance of postmitotic cells in the retina and alterations in normal maintenance pathways in DR with emphasis on ‘neuroprotection’. Finally, we discuss current neuroprotective strategies and future directions for the treatment of DR. ...

...References References 1. Barkana Y, Belkin M: Neuroprotection in ophthalmology: a review. Brain Res Bull 2004;62:447-453. 2. Chaum E: Retinal neuroprotection by growth factors: a mechanistic perspective. J Cell Biochem 2003;88:57-75. 3. Chidlow G, Wood JP, Casson RJ: Pharmacological...

...), unlike eicosanoids, which are derived from the 20C arachidonic acid family of essential fatty acids not enriched in the nervous system. We found that NPD1 is promptly made in response to oxidative stress, seizures and brain ischemia-reperfusion. NPD1 is neuroprotective in experimental brain damage...

... promising therapeutic regenerative strategies and pharmacologic agents studied in experimental and clinical trials for potential neonatal neuroprotection and HIE repair of the immature brain. Introduction The developing brain is extremely vulnerable to insults, and its responses to injury are very...

... mechanisms of disuse muscle atrophy remain unclear, free radical scavengers are known to play an important role in the development of disuse muscle atrophy. One of the neuroprotective agents, edaravone, a free radical scavenger, succeeded in proving clinical usefulness in a phase III clinical trial in Japan...

... from the retina to the visual cortex and will not be strictly limited to improving outflow or reducing inflow. But still, many future IOP-lowering options will be developed, including neuroprotective strategies aiming to directly prevent or significantly hinder neuronal cell damage. The goal...

.... Neuroprotective effects of coenzyme Q10 at rostral ventrolateral medulla against fatality during experimental endotoxemia in the rat. Shock. 2003;19:427–32. 8. Yen DHT, Chan JYH, Tseng HP, Huang CI, Lee CH, Chan SHH, Chang AYW. Depression of mitochondrial respiratory enzyme activity in rostral ventrolateral...

... palsy? Lancet Neurol 2012;11:556–566. 23. Thoresen M, Hobbs CE, Wood T, Chakkarapani E, Dingley J: Cooling combined with immediate or delayed xenon inhalation provides equivalent long-term neuroprotection after neonatal hypoxia-ischemia. J Cereb Blood Flow Metab 2009;29:707–714. 24. Faulkner S...

... system. Surg Neurol Int 2012;3:19. 12. Hogyes E, Nyakas C, Kiliaan A, Farkas T, Penke B, Luiten PG: Neuroprotective effect of developmental docosahexaenoic acid supplement against excitotoxic brain damage in infant rats. Neuroscience 2003;119:999-1012. 13. Petraglia AL, Winkler EA, Bailes JE...

... Abstract Astaxanthin (AST) is a powerful antioxidant that occurs naturally in a wide variety of living organisms. Based on the report claiming that AST could cross the brain-blood barrier, the aim of this study was to investigate the neuroprotective effect of AST by using an oxidative stress...

...: A randomized trial of brimonidine versus timolol in preserving visual function: results from the Low-Pressure Glaucoma Treatment Study. Am J Ophthalmol 2011;151:671-681. 12. Sena DF, Lindsley K: Neuroprotection for treatment of glaucoma in adults. The Cochrane Database Syst Rev 2013;2:CD006539. 13...

... function. The limited window of opportunityfor treatment with IGF-1 can be extended by spontaneous mild post-hypoxic hypothermia,probably due to delayed evolution of apoptotic processes. The efficacy of IGF-1 is specific toparticular cellular phenotypes and brain regions, and its neuroprotective effects...

... in the RVLM during the pro-life phase during brain stem death may entail hypoxia, followed by the sequential activation of HIF-1, HO-1, and HSP70, leading to neuroprotection by amelioration of cardiovascular depression. 7.3.1. Activation of HIF-1 Selectively Upregulates NOS I/PKG Signaling in the RVLM...

... traumatic axonal injury in a rodent head injury model. J Neurotrauma 2010;27:1617-1624. 53. Petraglia AL, Winkler EA, Bailes JE: Stuck at the bench: potential natural neuroprotective compounds for concussion. Surg Neurol Int 2011;2:146. 54. Wang X, Zhao X, Mao ZY, et al: Neuroprotective effect...

.... Neuroprotective effects of coenzyme Q10 at rostral ventrolateral medulla against fatality during experimental endotoxemia in the rat. Shock. 2003;19:427–32. 30. Li FCH, Chan JYH, Chan SHH, Chang AYW. In the rostral ventrolateral medulla, the 70 kDa heat shock protein (HSP70), but not HSP90, confers...