... challenges. Sinonasal neuroendocrine carcinoma (SNEC) and sinonasal undifferentiated carcinoma (SNUC) are types of sinonasal neuroendocrine tumor, together with olfactory neuroblastoma. They share overlapping clinical, radiological, and histopathological features, albeit with variability in behavior...

... Abstract Neuroendocrine tumors (NETs) comprise a heterogeneous group of malignancies with a very variable clinical expression and progression. They present unique properties that are important to consider for radiological and nuclear imaging, such as APUD-characteristics (amine precursor uptake...

... applications in treating numerous conditions such as precocious puberty, delayed puberty, prostate cancer, benign prostatic hyperplasia, endometriosis, uterine fibroids and also in in vitro fertilization protocols. The novel neuroendocrine peptides, kisspeptin (KP) and neurokinin B (NKB), were recently...

... Abstract Formerly named carcinoids, neuroendocrine tumors originate from diffuse endocrine cells, can involve any part of the gastrointestinal tract, endocrine pancreas and bronchopulmonary (BP) tree, and have a wide range of malignant potential. This chapter summarizes the data available...

... Abstract Neuroendocrine tumors are usually slow-growing tumors. Many of these are capable of secreting peptide hormones or biogenic amines that may lead to endocrine syndromes. Nonfunctioning tumors can either secrete no hormones at all, or secrete hormones not giving rise to endocrine symptoms...

... Abstract Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of tumors derived from multipotent neuroendocrine cells that have the inherent ability to synthesize and secrete a variety of substances (peptides and amines). When these substances are bioactive, NENs can present...

... Abstract An important role is reserved for nuclear imaging techniques in the imaging of neuroendocrine tumors (NETs). Somatostatin receptor scintigraphy (SRS) with 111 In-DTPA-octreotide is currently the most important tracer in the diagnosis, staging and selection for peptide receptor...

... Abstract Despite advances in radiological and metabolic imaging, standard axial endoscopy and endoscopic ultrasonography (EUS) still play a pivotal role in a number of neuroendocrine neoplasms (NENs) of the gastrointestinal and duodenopancreatic region. Upper gastrointestinal endoscopy...

... Abstract In this chapter, we give an overview of the genetic and epigenetic background of neuroendocrine tumors (NETs), in particular pancreatic and pulmonary NETs. Studying the mechanism of disease of the inherited syndromes that feature NETs has provided valuable insights that have...

... Abstract Surgery is the only treatment that may cure the patient with gastroenteropancreatic (GEP) neuroendocrine neoplasms (NENs) and should always be considered as the first-line treatment if radical resection can be achieved. Even in cases where radical surgery is not possible, palliative...

... Abstract An array of treatment modalities is currently available in the management of patients with neuroendocrine tumors (NETs). Complete resection of the primary tumor and all metastatic lesions represents the only approach possessing intent to cure. However, due to patients' disease...

..., including 90 Y and 177 Lu. Beyond the therapeutic interventions of surgery, no single drug class has had a more profound impact on the management of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) than somatostatin congeners such as octreotide acetate [ 1 ] and lanreotide [ 2...

... Abstract Whenever feasible, surgery represents the treatment of choice for pulmonary neuroendocrine neoplasms (NENs). In patients with hypersecreting tumors, wide metastatic spread or those not candidates for a surgical treatment, medical therapies may assure a control of the secretory pattern...

... Abstract Peptide receptor radionuclide therapy (PRRT) has been a well-accepted and effective therapeutic modality for inoperable or metastatic gastroenteropancreatic, bronchopulmonary and other neuroendocrine tumors for almost 2 decades. In general, PRRT is well tolerated with moderate toxicity...

... Abstract Neuroendocrine tumors (NETs) produce various hormones and bioactive substances and are known to express a large variety of peptide hormone receptors. While these hormones and receptors play a role in the pathophysiology of this heterogeneous group of tumors, they also form an important...

... Abstract Even though the neuroendocrine tumor (NET) field has entered the era of ‘targeted therapy', the role of cytotoxic chemotherapy continues to be debated. High response rates, ranging from 30 to 70% depending on the line of therapy, are consistently observed in the treatment of pancreatic...

... Abstract Neuroendocrine tumors (NET) of the gastroenteropancreatic (GEP) tract are heterogeneous neoplasms originating from multipotent stem cells in the gastrointestinal tract and pancreas. The incidence of NET has shown a marked increase over the last decades, and nowadays GEP NET represent...

... function and connectivity [ 8 ] - allowing for the possibility of cumulative effects on these processes. There are therefore a variety of ways in which inflammation and the neuroendocrine system can interact to contribute to the pathogenesis of depression. Before embarking on a discussion...

... Abstract Anorexia nervosa (AN) is a condition of severe undernutrition characterized by alterations in multiple neuroendocrine axes and peptides that signal or regulate energy intake. These alterations include a state of hypogonadotropic hypogonadism, a nutritionally acquired resistance...