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neurodegenerative

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Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 39
Published: 03 August 2016
10.1159/000445410
EISBN: 978-3-318-05865-9
... Abstract Background: The investigator is faced with several challenges when planning a randomized clinical trial (RCT). In the early phase, issues are particularly challenging for RCTs in neurodegenerative disorders (NDD). Summary: At the time of inclusion in the study, an early...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 39
Published: 03 August 2016
10.1159/000445453
EISBN: 978-3-318-05865-9
... in neurodegenerative diseases. Summary: Mendelian mutations in neurodegenerative diseases have been used as models for early diagnosis and intervention. On the other hand, genetic polymorphisms or risk factors for late-onset Alzheimer's disease (AD) or other neurodegenerative diseases, probably influencing drug...
Book Chapter
Series: Progress in Neurological Surgery
Volume: 28
Published: 17 June 2014
10.1159/000358787
EISBN: 978-3-318-02649-8
... Abstract A link between mild traumatic brain injury (mTBI) and neurodegenerative diseases, specifically Alzheimer's disease and chronic traumatic encephalopathy (CTE), has long been suspected. Shared clinical symptomology - most notably the prominent role of central auditory dysfunction...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 34
Published: 23 April 2014
10.1159/000356430
EISBN: 978-3-318-02568-2
... Abstract AD is the commonest neurodegenerative disorder resulting ultimately in dementia, a stage during which there is a loss of previously acquired intellectual skill and independent occupational and social function. Neurodegenerative changes within the hippocampus and an extended neuronal...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 63
Published: 12 June 2006
10.1159/000093759
EISBN: 978-3-318-01351-1
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Book Chapter
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series: Clinical & Performance Program
Volume: 6
Published: 23 May 2002
10.1159/000061856
EISBN: 978-3-318-00785-5
Book Chapter
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 30
Published: 30 November 1999
10.1159/000061433
EISBN: 978-3-318-00422-9
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Book Chapter
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Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 39
Published: 03 August 2016
10.1159/000445456
EISBN: 978-3-318-05865-9
.... This implies the inclusion of strictly homogeneous sample of patients that represent only in part the full disease spectrum. For this reason, pragmatic trials on representative samples of the general population are welcome. In neurodegenerative disorders, RCTs are generally performed in symptomatic individuals...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 36
Published: 16 December 2014
10.1159/000366238
EISBN: 978-3-318-02791-4
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 39
Published: 16 May 2014
EISBN: 978-3-318-02653-5
... in neurodegenerative diseases. Science 2012;336:1511-1513. 4. Balch WE, Morimoto RI, Dillin A, Kelly JW: Adapting proteostasis for disease intervention. Science 2008;319:916-919. 5. Coelho T, Adams D, Silva A, Lozeron P, et al: Safety and efficacy of RNAi therapy for transthyretin amyloidosis. N Engl J Med...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 92
Published: 24 January 2007
10.1159/000099273
EISBN: 978-3-318-01404-4
... Abstract Glaucoma is a chronic neurodegenerative disease of the optic nerve, in which apoptosisof retinal ganglion cells (RGCs) and progressive loss of optic nerve axons result in structuraland functional deficits in glaucoma patients. This neurodegenerative disease is indeed a leadingcause...
Book Chapter
Series: Advances in Biological Psychiatry
Volume: 28
Published: 23 April 2012
10.1159/000335393
EISBN: 978-3-8055-9803-3
... focused on the entorhinal cortex. It is thought to be affected by the neurodegenerative process of AD at a particularly early stage. Cross-sectional studies have shown that entorhinal cortex volumetry is unlikely to provide any additional benefit over hippocampus volume in identifying patients...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 39
Published: 16 May 2014
10.1159/000358905
EISBN: 978-3-318-02653-5
... Abstract Neurodegenerative diseases, including Alzheimer's, Parkinson's and prion diseases are a major and growing public health issue for aging populations as aging is the greatest risk factor for neurodegeneration. Protein misfolding and spreading are common to these neurodegenerative...
Book Chapter