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neuroblastoma

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Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 84
Published: 31 August 2020
10.1159/000457935
EISBN: 978-3-318-06670-8
... Abstract Olfactory neuroblastoma is a rare tumor. Nasal endoscopy typically identifies a soft mass arising from the olfactory cleft. Computer tomography and magnetic resonance imaging are mandatory for staging (in association with 18 F-fluorodeoxyglucose positron emission tomography) in high...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382027
EISBN: 978-3-318-05497-2
... Abstract Progressive neuroblastoma has a high risk of disease recurrence despite cancer treatment. Most patients can be identified at the time of diagnosis either by age over 18 months and the presence of distant metastases, or by amplification of the oncogene MYCN . As the body of knowledge...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382066
EISBN: 978-3-318-05497-2
... Abstract Neuroblastoma is a heterogeneous tumor that displays several numerical and structural copy number variations. Metastatic tumors of high-risk patients frequently show loss of chromosomes 1p, 4p, 9p, 11q and 14q, and gains of chromosomes 2p, 12p and 17q. Moreover, tumor tissue gene...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382085
EISBN: 978-3-318-05497-2
... Abstract High-risk neuroblastoma is frequently associated with amplification of the MYCN oncogene and this genetic aberration correlates strongly with poor prognosis in neuroblastoma patients. However, amplification of MYCN also offers new therapeutic opportunities since tumor cells...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382087
EISBN: 978-3-318-05497-2
... in adults and are anticipated to enter pediatric trials in the near future. In contrast to several other cancers, neuroblastoma is a predominantly p53 wild-type tumor; however, p53 pathway inactivation through MDM2 amplification and p14 ARF aberrations have been reported. Nongenotoxic activation...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382089
EISBN: 978-3-318-05497-2
.... Typically, apoptosis is disturbed in human malignancies and this dysregulation supports tumorigenesis as well as the resistance of cancers to current treatment strategies. For example, a variety of defects in apoptosis pathways have been identified in neuroblastoma, one of the most common solid tumors...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382090
EISBN: 978-3-318-05497-2
... endothelial growth factor, has been administered in several adult treatment protocols and has been approved for several other antiangiogenic drugs by the authorities. Neuroblastoma (NB) has been shown to be highly vascularized and angiogenic compounds have been discussed as potentially successful candidates...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382093
EISBN: 978-3-318-05497-2
... Abstract Anaplastic lymphoma kinase (ALK) is a membrane-bound receptor tyrosine kinase that when aberrantly expressed is capable of promoting neuroblastoma pathogenesis, and serves as a bona fide therapeutic target. In this review, we discuss the physiologic role of ALK, the mechanisms...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382098
EISBN: 978-3-318-05497-2
... Abstract Neuroblastoma (NB) is the most common solid tumor in infancy. High-risk NB with an exceedingly high recurrence rate of 56% and a persistently dismal outcome of relapsed and refractory disease with an overall survival of below 20% despite high-dose chemotherapeutic regimens...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382099
EISBN: 978-3-318-05497-2
... Abstract Evasion from the immune system has emerged as a novel hallmark in the genesis of neuroblastoma as well as in its progression. A profound knowledge of underlying immune regulatory mechanisms in neuroblastoma may be of vital importance to improve current and future immunotherapeutic...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382100
EISBN: 978-3-318-05497-2
... Abstract Immunotherapy of neuroblastoma is emerging as an important treatment option to further improve outcome for patients suffering from this challenging pediatric malignancy. In this short overview, current concepts in passive and active immune therapy approaches for neuroblastoma...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382101
EISBN: 978-3-318-05497-2
... Abstract Immunotherapy has emerged as an alternative strategy to treat high-risk neuroblastoma stage IV in addition to surgery and conventional radio- and chemotherapy. Today, most therapy protocols for high-risk neuroblastoma include myeloablative chemotherapy which attempts to eradicate...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382102
EISBN: 978-3-318-05497-2
... Abstract Detecting minimal amounts of tumor cells in bone marrow, peripheral blood, putative metastatic sites, lymph nodes or in other tissues, compartments or body fluids has become a major goal in cancer diagnostics. For neuroblastoma patients, the clinical relevance of minimal residual...
Book
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Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/isbn.978-3-318-05497-2
EISBN: 978-3-318-05497-2
Book Chapter
Series: Biovalley Monographs
Volume: 3
Published: 28 August 2012
10.1159/000339189
EISBN: 978-3-8055-9066-2
... Abstract The human neuroblastoma SH-SY5Y cell line is known to be a relevant cellular model for biochemical investigations on Alzheimer’s disease (AD). SH-SY5Y cells were also characterized as neurosteroid-producing cells expressing key steroidogenic enzymes. Therefore, SH-SY5Y cells were used...
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