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neonatal

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Book Chapter
Series: Frontiers in Diabetes
Volume: 25
Published: 19 April 2017
10.1159/000454748
EISBN: 978-3-318-06025-6
... forms of monogenic diabetes, such as neonatal diabetes mellitus (NDM), and the identification of literally tens of genes that cause diabetes, either in isolation or syndromic. Of note, NDM genetics not only shed light on several aspects of pancreatic β-cell biology, but revealed new and unexpected...
Book Chapter
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 96
Published: 30 June 2022
10.1159/000519391
EISBN: 978-3-318-07015-6
.... The challenge now is for future research to address these issues through consensus building around the important questions that need to be answered, how to report data from neonatal nutritional trials and whether large trials answering important questions can take place through development of consortia...
Book
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 94
Published: 09 June 2020
10.1159/000505030
EISBN: 978-3-318-06685-2
... microbiomes, specific bacteria are detectable both in human milk and infant feces, and that the bacteria in milk are a source of microbes colonizing the neonatal gut. If the microbes in human milk are discovered to contribute to the beneficial effects of breastfeeding, modulating or mimicking the milk...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 22
Published: 11 February 2020
10.1159/000495431
EISBN: 978-3-318-06621-0
... and Drug Administration as “how a patient feels, functions or survives” are scarce in neonatal outcome assessment. In contrast to this remarkable lack of sufficient outcome assessment tools for neonates, a vast amount of exposure data was collected in recent years. Introduction The main driver...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 51
Published: 04 December 2018
10.1159/000491038
EISBN: 978-3-318-06409-4
... Abstract Familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT) are genetically determined variants of primary hyperparathyroidism. FHH usually has a benign course, and patients do not require treatment, whereas NSHPT is a severe disorder often requiring...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 88
Published: 30 May 2017
10.1159/000455215
EISBN: 978-3-318-06031-7
... in the neonatal intestine [ 13 ]. There are several confounding factors that need to be taken into account in such studies (Fig. 1 ). Our group found that the microbiota measured in meconium during the first 48 h after birth was more diverse in preterm infants delivered by C-section [ 14 ]. This begs...
Book
Book Cover Image
Series: Nestlé Nutrition Institute Workshop Series
Volume: 86
Published: 28 June 2016
10.1159/isbn.978-3-318-05483-5
EISBN: 978-3-318-05483-5
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 18
Published: 17 November 2014
10.1159/000364987
EISBN: 978-3-318-02736-5
... and in neonates in particular; in these groups, the drug disposition and response can substantially differ from those in adults, with potentially dangerous results. ‘Grey baby syndrome', consisting of cyanosis, abdominal distension, abnormal respiration, emesis, cardiovascular collapse and death, is often cited...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 18
Published: 17 November 2014
10.1159/000364991
EISBN: 978-3-318-02736-5
... as intended and adverse drug reactions (ADRs) that arise when medicines are used as intended. This chapter focuses on neonatal pharmacovigilance as an essential part of neonatal clinical care and provides several clear guidelines to prevent or minimize ADRs. Two main steps are proposed: 1) minimizing risk...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 18
Published: 17 November 2014
10.1159/000365021
EISBN: 978-3-318-02736-5
... Abstract Neonatal drug dosing needs to be based on the physiological characteristics of the newborn and pharmacokinetic parameters of the drug. Overall, clearance is lower in neonates when compared to children or adults. In addition, there is already extensive between-individual variability...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 18
Published: 17 November 2014
10.1159/000365025
EISBN: 978-3-318-02736-5
...., for age extrapolation to neonates. In contrast, physiology-based pharmacokinetic (PBPK) models are mechanistic models that are independent of the measured concentrations and are based instead on the known anatomy and physiology of the living organism being modelled. They can also be used as a predictive...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 18
Published: 17 November 2014
10.1159/000365035
EISBN: 978-3-318-02736-5
... Abstract Off-label and unlicensed use of medicines is high in the paediatric population and specifically high in neonatal/paediatric intensive settings with up to 90% of cases. This is associated with higher incidence and severity of adverse drug reactions and can be addressed by including all...
Book
Book Cover Image
Series: Pediatric and Adolescent Medicine
Volume: 18
Published: 17 November 2014
10.1159/isbn.978-3-318-02736-5
EISBN: 978-3-318-02736-5
Book Chapter
Series: Endocrine Development
Volume: 26
Published: 15 September 2014
10.1159/000363154
EISBN: 978-3-318-02721-1
... Abstract The possibility of measuring thyroid hormones from blood dried on filter paper opened the way to identifying neonates with congenital hypothyroidism (CH) already in the first days of life. Consequently the early initiation of adequate replacement therapy opened the way to an effective...
Book Chapter
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 110
Published: 15 April 2014
10.1159/000358457
EISBN: 978-3-318-02641-2
... false conclusions. While an attempt was made to discuss all of the issues in the context of studies conducted in neonatal nutrition, the principles are applicable to practicing medicine in general. Being up to date with current medical research in order to deliver the best possible care...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 110
Published: 15 April 2014
10.1159/000358476
EISBN: 978-3-318-02641-2
... Abstract Most infant deaths (99%) occur in developing countries. The 14.9 million infants born prematurely (>11% of all live births) carry a particularly high mortality risk. This chapter discusses strategies to improve neonatal outcome under resource-restricted conditions, with a focus...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 109
Published: 16 January 2014
10.1159/000356106
EISBN: 978-3-318-02566-8