...Nodular Fasciitis Nodular fasciitis is a relatively common self-limited benign fibroblastic-myofibroblastic lesion, which can mimic malignant spindle-cell and pleomorphic sarcomas. Nodular fasciitis can occur in any age group, but is most common in young adults as a small, rapidly growing...

... Abstract Myofibroblasts in the periacinar area of the pancreas have been thought to mediatefibrogenesis in pancreatic fibrosis. We elucidated, by immunohistochemical and ultrastructuralstudies on surgically resected pancreatic tissue, the presence of myofibroblasts in thepancreatic duct wall...

... is paramount for the development of new therapeutic approaches to slowing progression. Experimental models of renal fibrosis have been essential in determining the mechanisms and sequence of progression of fibrogenesis, including the roles of endothelium, infiltrating leukocytes and myofibroblasts...

... areas in the form of nodular pancreatitis or cirrhosis-like pancreatitis. As for themechanism of interlobular fibrosis, incomplete obstruction of the pancreatic duct and theappearance of cells expressing α-smooth muscle actin, which is a marker for myofibroblasts,play an important role. On the other...

...References References 1. Baylor SM, Berg JW: Cross-classification and survival characteristics of 5,000 cases of cancer of the pancreas. J Surg Oncol 1973;5:335–358. 2. Yamamoto H, Yamaguchi H, Aishima S, Oda Y, Kohashi K, Oshiro Y, et al: Inflammatory myofibroblastic tumor versus IgG4...

... into myofibroblasts. Myofibroblasts are characteristicof smooth muscle cells and multifunctional cells. Myofibroblasts express manycytokines, growth factors (especially fibrogenetic) and also their receptors. Thus, myofibroblastsare key players in autocrine mechanisms. In early acute or chronic pancreatitis...

..., schwannomas, solitary fibrous tumors (SFTs), adenomatoid tumor, leiomyomas, and hamartomas. Inflammatory myofibroblastic tumors (IMTs) are pseudotumors that are considered to be of intermediate biological potential due to local recurrences and rarely distant metastases. Malignant mesenchymal tumors include...

...References References 1. Akbulut M, Gunhan-Bilgen I, Zekioglu O, Duyqulu G, Oktay A, Ozdemir N: Fine needle aspiration cytology of inflammatory myofibroblastic tumour (inflammatory pseudotumour) of the breast: a case report and review of the literature. Cytopathology 2007;18:384-387. 2...

... distributed chromatin distribution and inconspicuous nucleoli. Well-preserved fibroblasts show unipolar or bipolar cytoplasmic processes but bare nuclei of fibroblasts are common findings in smears (Fig. 2 ). Reactive fibroblasts/myofibroblasts present as fusiform, rounded, or triangular, occasionally...

... renal tubulointerstitial myofibroblast formation and tubulointerstitial fibrosis. Am J Pathol 1996; 148: 1169-1180 52. Goyer RA Miller CR Zhu SY and Victery W: Non-metallothioneinbound cadmium in the pathogenesis of cadmium nephrotoxicity in the rat. Toxicol Appl Pharmacol 1989; 101: 232-244...

... and adjunctive use of vascular endothelial growth factor inhibitors. In the more advanced stages of neovascularization, connective tissue myofibroblasts associated with new vessel growth contract causing progressive synechial closure of the anterior-chamber angle. Elevation of IOP, once significant secondary...

... of the surviving epithelial cells in fibrosis and attribute myofibroblast expansion to perivascular and interstitial fibroblasts. After severe injury, the proximal tubule cellular response is impaired with its proliferative response altered due to cell cycle arrest at the G2/M phase of the cell cycle, resulting...

... Abstract Recent years have seen a robust influx of exciting newobservations regarding the mechanisms that regulate the initiationand progression of pulmonary fibrosis. New therapeutictargets include the epithelial cell, myofibroblast as well aschronic inflammation. A schematic view...

... in periacinar collagenization. Furthermore, oursubsequent investigations suggest that the distribution of myofibroblasts in the periacinarand perilobular areas will provide a valuable clue to resolving the mechanism of the threedifferent types of pancreatic fibrosis related to pathogenesis. ...

... of the spindle cell population in theLeksell Gamma Knife-treated AVMs are similar to those designated as myofibroblasts in woundhealing processes and pathological fibromatoses. Considering that similar cell modificationshave not been demonstrated in control, nonirradiated AVM specimens, these myofibroblastsmight...

... in the irradiated cultivated samples, suggestingtransformation of resting fibroblasts onto activated myofibroblastic elements with contractilecapacity. This transformation process was confirmed by the appearance of TGF-β in the irradiatedAVM cell lines also. These data support the hypothesis that one...

... masquerade as fat necrosis Inflammatory Pseudotumor This rare tumor-like entity is defined as a nodular lesion consisting of interlacing bundles of myofibroblastic cells with a prominent inflammatory infiltrate composed mainly of plasma cells and lymphocytes, which can mimic malignancy both clinically...