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mucosal

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Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338463
EISBN: 978-3-318-02184-4
... in 1979. Misunderstanding the results of clinical pharmacological studies led us to start the biochemical pharmacological studies. Mucosal energy metabolism and capsaicin action were analyzed in detail by the simultaneously carried out measurements of membrane-bound ATP-dependent enzymes (membrane ATPase...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324591
EISBN: 978-3-8055-9723-4
... and regulation of both nasal and ocular immunity. Interestingly, cellular requirements for the organogenesis of NALT and TALT are quite different from those of other MALT (e.g. Peyer’s patches; PPs) and peripheral lymphoid tissues. Moreover, mucosal imprinting molecules of NALT and TALT inducer cells are totally...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324773
EISBN: 978-3-8055-9723-4
... Abstract Mucosal vaccine has been considered a promising strategy to prevent upper respiratory infections. As the immunization routes to induce mucosal immune responses, oral, intranasal, and sublingual immunizations are proposed for clinical application. Recently, it has been reported...
Book
Book Cover Image
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/isbn.978-3-8055-9723-4
EISBN: 978-3-8055-9723-4
Book Chapter
Book
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 94
Published: 09 June 2020
10.1159/000505336
EISBN: 978-3-318-06685-2
... Abstract The human mammary gland is an integral effector component of the common mucosal immune system. However, from physiological and immunological aspects, it displays several unique features not shared by other mucosal sites. The development, maturation, and activity of the mammary gland...
Book
Book Cover Image
Series: Nestlé Nutrition Institute Workshop Series
Volume: 94
Published: 09 June 2020
10.1159/isbn.978-3-318-06685-2
EISBN: 978-3-318-06685-2
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 77
Published: 29 April 2016
10.1159/000441875
EISBN: 978-3-318-05651-8
... was detected in human turbinates by Western blot analysis using an anti-H 1 receptor antibody, and H 1 receptor protein expression was markedly higher in patients with nasal allergy than in patients with nonallergic rhinitis [ 12 ]. Mucosal hyperresponsiveness is a key pathophysiologic characteristic...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 34
Published: 09 July 2015
10.1159/000381381
EISBN: 978-3-318-05474-3
... that breach the epithelial layer [ 11 , 13 , 32 ]. Recent reports have demonstrated that the mucosal Mϕ compartment requires continuous replenishment by blood monocytes that are Ly6C hi in mice and CD14 hi CD16 - in humans [ 11 , 33 ]. Under steady-state conditions, these monocytes enter the intestinal...
Book Chapter
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346510
EISBN: 978-3-318-02348-0
...). Inflammasomes and the Intestinal Mucosal Immune Response In the last decade, inflammasomes have been shown to play central roles in diverse mammalian physiological processes such as the antimicrobial response against bacteria, viruses and parasites, the pathogenesis of metabolic disease and tumorigenesis...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338398
EISBN: 978-3-318-02184-4
... injury. The chemical properties of most NSAIDs as organic acids accounts for their irritant properties which are achieved by their uptake through mucosal membranes as non-ionized acids and subsequent entrapment in mucosal cell in their ionized state. Our studies have shown that there is a direct...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338426
EISBN: 978-3-318-02184-4
... of the stomach may induce duodenogastric bile reflux, the latter being a pathogenic factor in the gastric mucosal injury. Thus, dysmotility in the gastroduodenal zone may be considered as a way for realization of the pathogenic potential of stress. According to the modern concepts [ 1 ], mammalian...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338428
EISBN: 978-3-318-02184-4
... Abstract Central nervous system has a profound role in regulation of gastric mucosal integrity. Different neuropeptides such as peptide YY, amylin, leptin, ghrelin, opioids (e.g. β-endorphin, deltorphin II, endomorphins), nociceptin, nocistatin, TLQP-21 and substance P were shown to protect...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 30
Published: 22 June 2012
10.1159/000338442
EISBN: 978-3-318-02184-4
...), to gastroprotection against stress-induced gastric lesions. First, Ang-(1–7) is produced in excessive amounts in the gastric mucosa of rodents, suggesting that this metabolite could be involved in the mechanism of gastric mucosal defense. Second, pretreatment with Ang-(1–7) attenuated the gastric lesions induced...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324586
EISBN: 978-3-8055-9723-4
.... The elucidation of the immune functions of the tonsils and mucosal membranes of the upper respiratory tract is considered to have important significance. The tonsils are also considered to play an important role as one of the causes of sleep apnea syndrome, and have been reported to be intimately involved...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324589
EISBN: 978-3-8055-9723-4
... Abstract Pneumococcal diseases such as otitis media, pneumonia, and meningitis are invariably preceded by nasopharyngeal colonization, and herd immunity against pneumococcal disease requires protection against colonization. An early study in mice demonstrated that mucosal immunization...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324590
EISBN: 978-3-8055-9723-4
... Abstract The upper respiratory tract including the nasal cavity, which is the first site of invading antigen exposure, plays a crucial role in host defense via the mucosal immune response. The epithelium of nasal mucosa forms a continuous barrier against a wide variety of exogenous antigens...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324607
EISBN: 978-3-8055-9723-4
... is produced by IgA1-secreting cells with abnormal activities of specific glycosyltransferases. The galactose deficiency affects IgA1 induced by mucosal antigens and elevated circulating levels of this abnormal IgA1 are hereditable, suggesting interactions of genetic and environmental factors. An abnormal...