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mpl

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Book Chapter
.... This review focuseson the recent insights into megakaryocytopoiesis and platelet production. Numerous platelet disordersare now explained by molecular abnormalities in the activity of some transcription factors or in signalingmolecules, like thrombopoietin and its receptor Mpl. These studies have also...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320803
EISBN: 978-3-8055-9567-4
... monophosphoryl lipid A ( 17 ) (known as MPL or MPLA) and further modifications thereof, appear to be safe and efficacious vaccine adjuvants, and MPL has received approval for use in hepatitis B vaccines ( 18 - 21 ). MPL's use as an adjuvant in vaccines targeting tuberculosis is also under investigation ( 22...
Book
Book Cover Image
Published: 08 January 2019
10.1159/isbn.978-1-910797-80-8
EISBN: 978-1-910797-80-8
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 17
Published: 29 November 2013
EISBN: 978-3-318-02423-4
..., et al: Evidence for a founder effect of the MPL-S505N mutation in eight Italian pedigrees with hereditary thrombocythemia. Haematologica 2009;94:1368-1374. 32. Mead AJ, Chowdhury O, Pecquet C, et al: Impact of isolated germline JAK2V617I mutation on human hematopoiesis. Blood 2013;121:4156-4165...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
EISBN: 978-3-8055-9567-4
...)979-87quiz 988 16. Erridge C, Bennett-Guerrero E, Poxton IR: Structure and function of lipopolysaccharides. Microbes Infect 2002;4:(8)837-51 17. Baldrick P, Richardson D, Elliott G, Wheeler AW: Safety evaluation of monophosphoryl lipid A (MPL): an immunostimulatory adjuvant. Regul Toxicol...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 1
Published: 22 April 2010
10.1159/000312646
EISBN: 978-3-8055-9244-4
... demonstrated that extrinsic physiological cytokines (macrophage colony-stimulating factor as well as G-CSF) can instruct hematopoietic lineage choice [ 30 ]. Another study showed that thrombopoietin (THPO) modulates HSC cell cycle progression at the osteoblast surface by the THPO/MPL pathway [ 31 ]. Treatment...
Book
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 17
Published: 29 November 2013
10.1159/000350348
EISBN: 978-3-318-02423-4
... been found in the genes encoding: (1) the stem cell/megakaryocyte lineage cytokine thrombopoietin (see [ 30 ] for additional references), (2) the thrombopoietin receptor MPL [ 31 ], and (3) one of the intracellular kinases downstream of the thrombopoietin receptor JAK2 (JAKV617I) [ 32...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 1
Published: 22 April 2010
EISBN: 978-3-8055-9244-4
..., Miyazaki H, Takahashi T, Suda T: Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell stem cell 2007;1:685-697 32. Qian H, Buza-Vidas N, Hyland CD, Jensen CT, Antonchuk J, Mansson R, Thoren LA, Ekblom M, Alexander WS, Jacobsen SE...
Book Chapter
Series: Current Problems in Dermatology
Volume: 45
Published: 13 March 2014
EISBN: 978-3-318-02527-9
... humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only. Vaccine 2006;24:5937-5949. 56. Schwarz TF: Clinical update of the AS04-adjuvanted human papillomavirus-16/18 cervical cancer vaccine, Cervarix...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 17
Published: 29 November 2013
10.1159/000350343
EISBN: 978-3-318-02423-4
.... Physical anomalies are present in ∼50% of children. Congenital amegakaryocytic thrombocytopenia is caused by mutations in the c-mpl gene in the majority of patients. Approximately 50% of patients subsequently develop childhood aplastic anaemia and there are several reports of myelodysplasia...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 17
Published: 29 November 2013
10.1159/000350344
EISBN: 978-3-318-02423-4
... are currently licensed for use in adults, with other agents in development. Both agents work through the TPO receptor (previously called the MPL receptor) although with different modes of action. Romiplostim (AMG 53, Nplate, Amgen) is a recombinant protein classified as a peptibody. It is comprised of two...
Book Chapter
Series: Current Problems in Dermatology
Volume: 45
Published: 13 March 2014
10.1159/000356183
EISBN: 978-3-318-02527-9
.... Giannini SL, Hanon E, Moris P, Van Mechelen M, Morel S, Dessy F, Fourneau MA, Colau B, Suzich J, Losonksy G, Martin MT, Dubin G, Wettendorff MA: Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt...
Book
Book Cover Image
Series: Chemical Immunology and Allergy
Volume: 80
Published: 29 April 2002
10.1159/isbn.978-3-318-00816-6
EISBN: 978-3-318-00816-6
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 84
Published: 31 August 2020
10.1159/000457923
EISBN: 978-3-318-06670-8
... the blocked mucus within the posterior ethmoid cells (pec). A marked bone sclerosis (black arrows) surrounds the infraorbital nerve groove (ion), at the same time erosion of the maxillary sinus wall is present (curved white arrow). mpl, medial pterygoid plate. Olfactory Neuroblastoma ONB can...
Book
Book
Book Cover Image
Series: Progress in Tumor Research
Volume: 36
Published: 07 June 1999
10.1159/isbn.978-3-318-00397-0
EISBN: 978-3-318-00397-0
Book
Book Cover Image
Series: Pediatric and Adolescent Medicine
Volume: 17
Published: 29 November 2013
10.1159/isbn.978-3-318-02423-4
EISBN: 978-3-318-02423-4
Book
Book Cover Image
Series: Contributions to Oncology
Volume: 53
Published: 30 January 1998
10.1159/isbn.978-3-318-03436-3
EISBN: 978-3-318-03436-3
Book
Book Cover Image
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/isbn.978-3-8055-9567-4
EISBN: 978-3-8055-9567-4