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Book Chapter
Series: Contributions to Nephrology
Volume: 191
Published: 18 September 2017
10.1159/000479252
EISBN: 978-3-318-06117-8
... with poor outcomes in a CKD setting. The present review focuses on a specific class of uremic toxins (the “middle molecules”), which includes well-known candidates like beta-2 microglobulin and fibroblast growth factor 23. Here, we summarize the epidemiological evidence linking the middle-molecule uremic...
Book Chapter
Series: Contributions to Nephrology
Volume: 191
Published: 18 September 2017
10.1159/000479266
EISBN: 978-3-318-06117-8
... Abstract Large middle molecules (LMM) are an important subclass of uremic toxins. Many of them have been linked with poor outcomes in hemodialysis (HD) patients. The onset of high-flux membranes and convective techniques allowed to dramatically improve their clearance but without a clear...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 77
Published: 29 April 2016
10.1159/000441881
EISBN: 978-3-318-05651-8
... Abstract Junctional adhesion molecule-A (JAM-A), which belongs to the IgG superfamily, is one of the tight junction molecules. JAM-A is dysregulated in various cancers and is closely associated with the invasion and metastasis of cancers such as breast cancer, lung cancer and pancreatic cancer...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320823
EISBN: 978-3-8055-9567-4
... killing have indicated that small-molecule elastase inhibitors do not interfere with neutrophil killing of Gram-positive bacteria although similar data with Gram-negative bacteria are not available ( 15 ). However, on this basis, inhibition of intracellular NE may not be the preferred therapeutic approach...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320828
EISBN: 978-3-8055-9567-4
... to regulate eosinophilic inflammation, mucus secretion and airway hyperresponsiveness ( 16 , 17 ). Pharmacology The most recently described small-molecule inhibitors of TGF-ßRI are summarized in Table 1. (See Yingling et al. [ 18 ] for a recent review on the structural properties of TGF-ßRI kinase...
Book Chapter
Book Chapter
Series: Progress in Respiratory Research
Volume: 31
Published: 08 March 2001
10.1159/000062160
EISBN: 978-3-318-00424-3
Book Chapter
Series: Progress in Respiratory Research
Volume: 31
Published: 08 March 2001
10.1159/000062161
EISBN: 978-3-318-00424-3
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