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Series: Monographs in Human Genetics
Volume: 20
Published: 26 April 2016
10.1159/000444568
EISBN: 978-3-318-05856-7
... in a controlled environment. Here, we describe the genetic modifiers that contribute to hearing loss susceptibility and resistance in inbred mice and the genetic approaches used to identify the modifiers in the genetic background, with emphasis on the AHL mutation of the cadherin 23 gene Cdh23 ahl . Cdh23...
Book Chapter
Series: Biovalley Monographs
Volume: 3
Published: 28 August 2012
10.1159/000339190
EISBN: 978-3-8055-9066-2
... interventions targeting the metabotropic glutamate receptor 5 (mGlu5) and the GABA-B receptor, respectively, have been reported to correct a broad range of FXS phenotypes in Fmr1 knockout mice. It is of great interest how these findings obtained from the FXS mouse model may translate into ongoing clinical...
Book Chapter
Series: Contributions to Nephrology
Volume: 170
Published: 08 June 2011
10.1159/000325651
EISBN: 978-3-8055-9743-2
... Abstract The laboratory mouse is among the best characterized and flexible experimental platforms available for the study of diabetic nephropathy (DN). However, studies of progressive kidney disease in mice have underscored several important technical considerations for accurate phenotyping...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 62
Published: 12 August 2008
10.1159/000146256
EISBN: 978-3-8055-8554-5
... different mouse models with insulin resistance. Treatmentwith norfloxacin and ampicillin for 2 weeks reduced the cecal bacterial DNA below thelevel of detection in ob/ob, diet-induced obese and insulin resistance (DIO) mice, andsignificantly improved fasting glycemia and oral glucose tolerance...
Book Chapter
Series: Contributions to Nephrology
Volume: 157
Published: 25 May 2007
10.1159/000102453
EISBN: 978-3-318-01467-9
... Abstract The glycosylation of glycoproteins is important for their biological activity, conformationand stability. Recent studies indicate that aberrant glycosylation causes various humandisorders. Here we report that mice lacking Β-1,4-galactosyltransferase-I (Β4GalT-I), whichtransfers...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 35
Published: 09 October 2006
10.1159/000096556
EISBN: 978-3-318-01390-0
... Abstract Hypopituitary Ames dwarf mice and growth-hormone-resistant (growth hormonereceptor knockout, GHRKO) mice have reduced plasma levels of insulin-like growth factor 1and insulin, enhanced insulin sensitivity and a remarkably increased life span. This resemblesthe phenotypic...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087644
EISBN: 978-3-318-01232-3
... cell functions in vivo by comparing the biological responsesin wild-type mice, genetically mast cell-deficient mice, and ‘mast cell knock-in mice’(mast cell-deficient mice selectively repaired of their mast cell deficiency). Studies using‘mast cell knock-in mice’ have indicated that mast cells can...
Book Chapter
Book Chapter
Series: Monographs in Virology
Volume: 25
Published: 09 March 2005
10.1159/000084312
EISBN: 978-3-318-01134-0
Book Chapter
Series: Monographs in Virology
Volume: 25
Published: 09 March 2005
10.1159/000084318
EISBN: 978-3-318-01134-0
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