... of altered methylation of the genomic DNA may be responsible for such metabolic patterning. Methionine, an essential amino acid, plays a critical role in the methyltranferases involved in the methylation by providing the one-carbon units via the methionine transmethylation cycle. Because of its interaction...

... Abstract S-adenosylmethionine (SAMe), widely available as a nutritional supplement, hasrapidly moved from being a methyl donor to a key metabolite that regulates hepatocytegrowth, death and differentiation. Biosynthesis of SAMe occurs in all mammalian cells asthe first step in methionine...

... Abstract In order to characterize modification of the metabolism of low-grade gliomas (LGG) after gamma knife radiosurgery (GKR), we prospectively studied the uptake of [11C]methionine of 7 patients every 3–6 months after GKR treatment for a histologically confirmed, residual or recurrent LGG...

... with 0.4 M ammonia salts (0.2 M NH4 acetate + 0.2 M NH4HCO3, pH 7.4) for 24 hrs at 0.7 ml/100 g/hr. Untreated rats served as controls. Another group of rats were pretreated with methionine sulfoximine (MSO) 150 mg/kg which inhibits glutamine synthesis. Brain-uptake index, as defined by Oldendorf...

... of a number of genes. The non-essential amino acid serine, folate and the essential amino acid methionine constitute the key components of methyl transfer. Since the methionine and folate cycles are ubiquitously present in every cell in the body and participate in key metabolic reactions, perturbation...

... by indicator amino acid oxidation technique. Am J Clin Nutr 2006;83:619-623. 8. Humayun MA, Turner JM, Elango R, Rafii M, Langos V, Ball RO, Pencharz PB: Minimum methionine requirement and cysteine sparing of methionine in healthy school-age children. Am J Clin Nutr 2006;84:1080-1085. 9. Pencharz PB...

... in abundance. In VLBW infants, daily intakes of the IAA methionine and 3 CIAAs are still below the advisable intakes. In LBW infants (<2,000 g) receiving 3.5 g HM protein per kg BW daily intakes of 1 IAA and 3 CIAAs would be too low. Preterm infants should receive HMFs which provide adequate amounts of AAs...

... more invasive techniques. The question I suppose you are alluding to is, where is the methionine getting oxidized? The transsulfuration pathway is very interesting in that it is not expressed in every organ and tissue in the body, and the major organs are the liver, gut, pancreas and kidney. Our...

..., et al: Methionine metabolism in human pregnancy. Am J Clin Nutr 2010;91:357-365. 9. Kalhan SC, Gruca LL, Parimi PS, et al: Serine metabolism in human pregnancy. Am J Physiol Endocrinol Metab 2003;284:E733-E740. 10. Cetin I, Hirst K, Corbetta C, et al: Plasma and erythrocyte amino acids...

... ethanol intake. The central roleof ethanol metabolism in mediating many of the detrimental effects of ethanol consumptionhas led to considerable interest in the study and use of dietary antioxidants to blunt theseeffects. Included in this group are S-adenosyl-L-methionine and plant-derived flavanoids. ...

... to be deficient in one or more of the IAA and are called ‘incomplete proteins'. Specifically, cereal grains are deficient in lysine and legumes are deficient in methionine. Thus, for children who are actively growing, it is recommended to ensure sufficient intake of ‘high-quality' protein. Children who restrict...

... Glutathione and C1 Metabolism Disturbances in single-carbon metabolism appear to be related to a variety of neuropsychiatric disorders, covering a broad spectrum that includes depression [ 148 ], autism [ 149 ] and psychosis [ 150 , 151 ]. Indeed, the enzymes and metabolites of the methionine and folate...

...References References 1. Kurpad AV, Anand P, Dwarkanath P, et al: Whole body methionine kinetics, transmethylation, transulfuration and remethylation during pregnancy. Clin Nutr 2013 Jan 11. doi:pii: S0261-5614(13)00025-3. 10.1016/j.clnu.2012.12.016. [Epub ahead of print] PMID: 23356955. 2...

... amino acids in rats after portocaval shunt treated with methionine sulfoximine (MSO, 150 mg/kg), which inhibits glutamine synthesis. Brain ammonia was also measured in rats killed by freezing the brain in liquid N2 in situ. ...

.... The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans. J Nutr. 2006;136(6 Suppl):1682S–93S. 7. Mager DR, Wykes LJ, Ball RO, Pencharz PB. Branched-chain amino acid requirements in school-aged children determined by indicator amino acid oxidation...

... development and dietary requirements in adults. Annu Rev Nutr 2006;26:229-250 4. Niculescu MD, Zeisel SH: Diet methyl donors and DNA methylation: interactions between dietary folate methionine and choline. J Nutr 2002;132:2333S-2335S 5. Finkelstein JD: Pathways and regulation of homocysteine...

... methionine. This is the precursor for synthesis of S-adenosylmethionine, the universal methyl donor needed for methylation of DNA, RNA and proteins. It is important to realize that choline, methionine and folate metabolism are inter-related at the step that homocysteine is methylated to form methionine [ 5...