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metformin

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Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
10.1159/000506545
EISBN: 978-3-318-06734-7
... Abstract Today, all guidelines for the treatment of type 2 diabetes recommend the biguanide metformin as the first-line blood glucose-lowering agent. This was due to the encouraging results of the UK Prospective Diabetes Study (UKPDS). Previously, the long history of the guanidine derivatives...
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Book Chapter
Series: Frontiers of Hormone Research
Volume: 40
Published: 19 October 2012
10.1159/000341837
EISBN: 978-3-318-02239-1
... of metabolic comorbidities, and, finally, improved ovulation and fertility. This can be achieved with the help of specific agents, particularly metformin and thiazolidinediones. They may ease the suffering of women with PCOS because insulin resistance and hyperinsulinemia appear to be major contributors...
Book Chapter
Series: Frontiers in Diabetes
Volume: 23
Published: 15 September 2014
10.1159/000362475
EISBN: 978-3-318-02700-6
... Abstract Patients with diabetes differ in how their diabetes responds to treatment. Some individuals can have a marked glycaemic response; others have a poor response. Some have adverse drug reactions (e.g. hypoglycaemia with sulphonylureas, or diarrhoea with metformin), others do not. Diabetes...
Book Chapter
Series: Frontiers in Diabetes
Volume: 28
Published: 03 January 2020
10.1159/000480166
EISBN: 978-3-318-06612-8
.... Worldwide the approach of the pharmacological treatment of GDM has significant differences mainly depending on local guidelines. Most of GDM cases can be treated with metformin, glyburide, or insulin. The critical points for oral agents concern the transplacental crossing, the effects on maternal glycemic...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 40
Published: 19 October 2012
EISBN: 978-3-318-02239-1
...: The insulin-related ovarian regulatory system in health and disease. Endocr Rev 1999;20:535 4. Palomba S, Falbo A, Zullo F, Orio F, Jr: Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. Endocr Rev 2009;30:1 5. Diamanti-Kandarakis E: Metformin...
Book Chapter
Series: Endocrine Development
Volume: 31
Published: 27 January 2016
10.1159/000439369
EISBN: 978-3-318-05639-6
... Abstract An array of oral agents is available for the treatment of hyperglycaemia in type 2 diabetes. This systematic inventory focuses on ‘old' oral agents, including metformin, sulfonylureas (SUs), thiazolidinediones, alpha glucosidase inhibitors, and meglitinides. Twelve meta-analyses...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 40
Published: 09 October 2014
10.1159/000364982
EISBN: 978-3-318-02730-3
... or cellular lesions which could be deleted by apoptosis. The same agents can induce damage followed by neoplastic transformation, thus leading to cancer. Metformin, rapamycin, and some other compounds with mTOR and IIS-inhibitory potential (resveratrol, melatonin) are able to modify both aging...
Book Chapter
Series: Frontiers in Diabetes
Volume: 23
Published: 15 September 2014
EISBN: 978-3-318-02700-6
...References References 1. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998;352:854-865. 2. Kahn SE, Haffner SM, Heise MA, Herman WH, et al: Glycemic...
Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
10.1159/000506558
EISBN: 978-3-318-06734-7
... that biguanides might be useful in managing diabetes was noted in the early 1900s; however, metformin did not achieve worldwide use and recognition as the first-line treatment for type 2 diabetes until the late 1990s. The hypoglycemic potency of sulfa drugs was first noted in 1942, but the introduction...
Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
EISBN: 978-3-318-06734-7
...-year experience with dimethyl guanylguanidine (metformin, glucaphage) in diabetic therapy. Wien Med Wochenschr 1963;113:599–602. 22. Sterne J: The present state of knowledge on the mode of action of the antidiabetic diguanides. Metabolism 1964;13:791–798. 23. Sterne J, Joffroy-Lavieuville MJ...
Book Chapter
Series: Frontiers in Diabetes
Volume: 29
Published: 31 August 2020
EISBN: 978-3-318-06734-7
.... Klin Wchnschr 1926;5:2011. 3. Slotta KH, Tschesche R: Über Biguanide, II: Die blutzucker-senkende Wirkung der Biguanide. Ber Dtsch Chem Ges 1929;62:1398–1405. 4. DeFronzo RA, Goodman AM; Multicenter Metformin Study Group: Efficacy of metformin in patients with non-insulin-dependent diabetes...
Book Chapter
Series: Interdisciplinary Topics in Gerontology and Geriatrics
Volume: 40
Published: 09 October 2014
EISBN: 978-3-318-02730-3
..., Piskunova TS, Popovich IG, Zabezhinski MA, Kovalenko IG, Poroshina TE, Semenchenko AV, Provinciali M, Re F, Franceschi C: Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice. Exp Gerontol 2005;40:685-693. 11. Anisimov VN, Egormin PA...
Book Chapter
Series: Frontiers in Diabetes
Volume: 28
Published: 03 January 2020
EISBN: 978-3-318-06612-8
...References References 1. Martis R, Crowther CA, Shepherd E, Alsweiler J, Downie MR, Brown J: Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews. Cochrane Database Syst Rev 2018;8:CD012327. 2. Barbour LA, Feig DS. Metformin for gestational...
Book Chapter
Series: Advances in Cardiology
Volume: 45
Published: 14 February 2008
10.1159/000115193
EISBN: 978-3-8055-8428-9
... reported in 5% of patients, and these drugs are contraindicated in diabeticswith NYHA class III or IV cardiac status. The long-term effects of alpha-glucosidaseinhibitors on morbidity and mortality rates and on diabetic micro- and macrovascular complicationsis still unknown. Combined sulfonylurea/metformin...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series: Clinical & Performance Program
Volume: 11
Published: 14 August 2006
10.1159/000094404
EISBN: 978-3-318-01329-0
... to haveother strategies, either pharmacological or surgical, that can be used as an adjunct oralternative to lifestyle modification. The Chinese study showed that metformin andacarbose could reduce the risk of diabetes by 65 and 83%, respectively, in IGT subjects.The efficacy of metformin was confirmed...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 40
Published: 19 October 2012
10.1159/000341824
EISBN: 978-3-318-02239-1
... modifications should be stressed, particularly weight loss, increased exercise, smoking cessation and reduced alcohol consumption. The pharmacological treatment of choice for the induction of ovulation and for achieving live birth is the combination of metformin and clomiphene citrate. If this combination...