... and the current state of the art for blood purification strategies to identify the most feasible solution to reduce immunological dysfunction and waste compound clearance. In this regard, the current literature underlines the high efficacy of polymethyl methacrylate membrane hemofilters to overcome...

... Abstract Sepsis and multiple organ failure (MOF) are characterized by multiple hemodynamic changes and imbalanced immune response of the patient. Oxiris is a highly adsorptive membrane with the ability to remove cytokines and endotoxins, as well as to perform renal replacement therapy. Here we...

... Abstract Extracorporeal therapy for end-stage renal disease is now provided to more than three million patients globally. Nearly all treatments are performed with filters containing hollow fiber membranes, removing solutes and water by diffusion, convection, and ultrafiltration. In this review...

... Abstract Despite advances in renal replacement therapy, the adequate removal of uremic toxins over a broad molecular weight range remains one of the unmet needs in hemodialysis. Therefore, membrane innovation is currently directed towards enhanced removal of uremic toxins and increased membrane...

... Abstract Background: Dialysis membranes are often made from synthetic polymers, such as polysulfone. However, membranes made from cellulose triacetate have superior biocompatibility and have been used since the 1980s. On-line hemodiafiltration treatment accompanied by massive fluid...

... with the membrane surface to aggregate with white blood cells and attack the endothelium of the blood vessels. Therefore, we tried to develop a new membrane with no adsorption and no platelet activation. Summary: Polysulfone (PS) membranes with polyvinylpyrrolidone (PVP) as a hydrophilic agent are widely used...

... Abstract Background: Poly(methyl methacrylate) (PMMA) membranes adsorb several kinds of proteins and can remove high-molecular-weight proteins, including uremic toxins, which are not removed efficiently by hemodialysis or hemodiafiltration. However, the antithrombogenicity of PMMA membranes...

... guttae, corneal edema, and reduced vision. The Descemet membrane thickens and develops excrescences known histopathologically as guttae. Stromal edema develops, and the corneal thickness may increase to over 1,000 μm. When the edema is severe, the corneal epithelium can detach from its basement membrane...

... TNF in vitro. However, mere neutralization of soluble TNF cannot be the only therapeutic modality of therapeutically efficient anti-TNF agents, as accumulating evidence indicates that effector cells expressing membrane-bound TNF are critically involved in the induction and perpetuation of chronic...

... for the normal mammalian development and exerts its action on virtually all types of tissue. It has been thought initially that thyroid hormone (TH) passage into the target cells occurred by passive diffusion through the lipid bilayer of cell membranes. With the advent of new genetic technology, we are learning...

... Abstract Epiretinal membrane (ERM) is a relatively common macular disease, which forms along the surface of the internal limiting membrane of the retina. Currently, microincision vitrectomy surgery (MIVS) has been confirmed as a minimally invasive and very safe modality of treatment...

... Abstract Suspensions of human embryonic stem cell-derived retinal pigment epithelium (hES-RPE) and human fetal RPE resurface aged and age-related macular degeneration (AMD) Bruch's membrane to a limited degree at day 21 in organ culture. Survival and differentiation of hES-RPE and human fetal...

... Abstract The lipid membrane bilayer undergoes continuous changes, and its lipid composition is both adaptive and highly varied, with substantial molecular variety. The balance of dietary fats, namely saturated versus unsaturated, and polyunsaturated fatty acids (PUFA) of the n-6 series versus...

... Abstract Macular epiretinal membranes (ERM) are formed by glial cell proliferation that covers the macular surface, and result in retinal thickening and distortion when they contract. These membranes are in most cases idiopathic, i.e. exclusively due to posterior vitreous detachment, even...