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Series: ESASO Course Series
Volume: 11
Published: 28 December 2020
10.1159/000485292
EISBN: 978-3-318-06643-2
... Abstract Optical coherence tomography angiography (OCTA) has revolutionized the field of ophthalmology to the benefit of all its subspecialties. In the field of ocular oncology, much of its role has been in the evaluation of choroidal melanoma and complications of radiation. Although the role...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 84
Published: 31 August 2020
10.1159/000457937
EISBN: 978-3-318-06670-8
... Abstract Sinonasal malignant mucosal melanoma (SNMM) is a rare, aggressive, and capricious tumour accounting for 4% of sinonasal malignancies. Recent studies suggest an increasing frequency. There are few large published series, but all authors report poor outcomes irrespective of treatment...
Book Chapter
Series: Current Problems in Dermatology
Volume: 53
Published: 13 November 2017
10.1159/000478081
EISBN: 978-3-318-06101-7
... diagnosis and management of these skin toxicities are essential for optimal patient care and to avoid unnecessary cessation of anti-cancer therapies. This review summarises a wide range of cutaneous manifestations associated with immunotherapy usage in patients with metastatic melanoma. Introduction...
Book Chapter
Series: Progress in Tumor Research
Volume: 42
Published: 09 September 2015
10.1159/000436998
EISBN: 978-3-318-05590-0
... Abstract The history of immunotherapy is rooted in the treatment of melanoma and therapy with immune checkpoint-blocking agents is now a cornerstone for the treatment of metastatic melanoma. The first effective immunotherapies approved by the US Food and Drug Administration in melanoma included...
Book Chapter
Series: Progress in Tumor Research
Volume: 41
Published: 19 February 2014
10.1159/000355903
EISBN: 978-3-318-02542-2
... Abstract The treatment of stage IV melanoma has witnessed a very impressive pace of innovation in recent years, to a point where the management of these patients has very little in common to what was standard practice 5 years ago. If the gain in overall survival, the high response rates...
Book Chapter
Series: Current Problems in Dermatology
Volume: 44
Published: 28 May 2013
10.1159/000350055
EISBN: 978-3-318-02404-3
... of cumulative life course impairment (CLCI) in skin cancer patients has been carried out, a few studies suggest that skin cancer may strongly impair quality of life and eventually determine a significant CLCI (melanoma more than nonmelanoma skin cancer). Obviously, the life course of patients with melanoma...
Book Chapter
Series: Developments in Ophthalmology
Volume: 49
Published: 24 October 2011
10.1159/000330613
EISBN: 978-3-8055-9791-3
... Abstract The diagnosis of uveal melanoma is based on clinical examination with the slit lamp and indirect ophthalmoscope together with ultrasonography of the eye. Large to medium-sized melanomas are reliably diagnosed using these methods. The challenge lies in early detection. Small melanomas...
Book Chapter
Series: Developments in Ophthalmology
Volume: 49
Published: 24 October 2011
10.1159/000328251
EISBN: 978-3-8055-9791-3
... Abstract Uveal melanomas can be treated by various forms and combinations of radiotherapy, phototherapy and local resection, which need to be tailored to the tumour size, location and extent as well as the patient’s needs, fears and wishes. Many factors complicate the process of treatment...
Book Chapter
Series: Developments in Ophthalmology
Volume: 49
Published: 24 October 2011
10.1159/000328257
EISBN: 978-3-8055-9791-3
... Abstract Proton beam irradiation of uveal melanoma has great advantages compared to brachytherapy because of the homogenous dose delivered to the tumor and the possibility of sparing normal tissue close to the tumor. We describe the technique of proton beam therapy including the surgical...
Book Chapter
Series: Developments in Ophthalmology
Volume: 49
Published: 24 October 2011
10.1159/000328259
EISBN: 978-3-8055-9791-3
... Abstract Stereotactic photon beam irradiation has been under clinical investigation for the treatment of uveal melanoma for over 15 years. Single-fraction stereotactic radiosurgery (SRS) is usually done with a gamma knife as well as more recently with a cyberknife. The therapeutic single dose...
Book Chapter
Series: Developments in Ophthalmology
Volume: 49
Published: 24 October 2011
10.1159/000328261
EISBN: 978-3-8055-9791-3
... Abstract Local resection of uveal melanoma is aimed at conserving the eye and useful vision while removing any threat of metastatic spread. The tumour can be removed en bloc through a scleral opening (i.e., ‘exoresection’) or in a piecemeal fashion with a vitreous cutter passed through...
Book Chapter
Series: Developments in Ophthalmology
Volume: 49
Published: 24 October 2011
10.1159/000328263
EISBN: 978-3-8055-9791-3
... procedures are becoming the main prognostic (and theoretically also diagnostic) tools for uveal melanoma. In spite of the widespread use of biopsies in general surgical practice, in ophthalmic oncology, indications and contraindications for biopsy continue to be under debate. The purpose of this paper...
Book Chapter
Series: Developments in Ophthalmology
Volume: 49
Published: 24 October 2011
10.1159/000329591
EISBN: 978-3-8055-9791-3
... are a marker for disease stage and an indicator of metastasis. VEGF levels are significantly elevated in uveal melanoma patients with metastatic disease compared to patients without metastases. Anti-angiogenic therapy, such as bevacizumab, is currently used for the treatment of metastases of several...
Book Chapter
Series: Developments in Ophthalmology
Volume: 49
Published: 24 October 2011
10.1159/000328268
EISBN: 978-3-8055-9791-3
... Abstract Uveal melanoma is a malignancy with exceptional features for treatment with immunotherapy. Primary uveal melanoma can be treated with a variety of therapies that may limit the growth of the primary tumor in the eye and partially preserve vision. However, none of these treatment...
Book Chapter
Series: Developments in Ophthalmology
Volume: 49
Published: 24 October 2011
10.1159/000328270
EISBN: 978-3-8055-9791-3
... Abstract Uveal melanoma (UM) arises from neural crest-derived melanocytes of the choroid and the ciliary body. About 50% of patients develop metastatic disease despite efficient control of the primary tumor. For about 15 years, cytogenetic and, recently, genome-wide analysis techniques have...