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Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522457
EISBN: 978-3-318-07054-5
... substrate of this life-and-death signal in the rostral ventrolateral medulla (RVLM) therefore provides a new vista in translational research on brain stem death. 3.1. The Rostral Ventrolateral Medulla Is Responsible for the Maintenance of Sympathetic Vasomotor Tone Considerable experimental evidence...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522458
EISBN: 978-3-318-07054-5
... in the rostral ventrolateral medulla (RVLM). As will be elaborated in Chapters 4–10, intricate interactions at transcriptional, translational, and post-translational levels between myriad molecules and cellular processes in the RVLM that underpin brain stem death have been unveiled. Our search...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522459
EISBN: 978-3-318-07054-5
... ventrolateral medulla (RVLM). This was an easy task because an obvious target resides in the mitochondria. Nevertheless, as described previously in details in two reviews [ 1, 2 ], in addition to the identification of mitochondrial bioenergetic failure and impaired defense by superoxide dismutase (SOD...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522460
EISBN: 978-3-318-07054-5
... ]. Given that death posts the most severe threat to existence, we undertook a series of studies in early 2000s on HSPs, and found that at least HSP60 and HSP70 in the rostral ventrolateral medulla (RVLM) play a pro-life role during brain stem death. 6.1. Heat Shock Proteins as Molecular Chaperones...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522461
EISBN: 978-3-318-07054-5
... a series of adaptive responses. Thus, it is generally contended that hypoxia serves as the culprit for many abnormal brain functions. Two lines of evidence suggest that hypoxia plays a critical role during brain stem death. First, hypoxia occurs at the rostral ventrolateral medulla (RVLM) during...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522462
EISBN: 978-3-318-07054-5
... in the rostral ventrolateral medulla (RVLM) [ 6 ], and one of the best-known targets of the UPS is activation of NF-κB [ 7‒10 ]. We also observed that drastic difference in quantity exists between upregulation of NOS II mRNA and protein in the RVLM in our brain stem death model [ 11 ]. In a series of experiments...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522463
EISBN: 978-3-318-07054-5
... (see Chapters 4, 7, and 8), are among the many transcription factors that are sumoylated. Subsequent experiments from our group confirmed that sumoylation of HIF-1α and NF-κB in the rostral ventrolateral medulla (RVLM) plays a pro-life role during brain stem death. 9.1. Conjugation Like...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522464
EISBN: 978-3-318-07054-5
... for this classical tumorigenic signaling in brain stem death. Specifically, activation of PI3K/Akt signaling in the rostral ventrolateral medulla (RVLM) via an important upstream cofactor, FLJ10540 [ 15‒17 ], subserves a pro-death role in brain stem death by eliciting defunct cardiovascular regulation. At the same...
Book Chapter
Series: Contributions to Nephrology
Volume: 123
Published: 14 September 1998
10.1159/000059912
EISBN: 978-3-318-00337-6
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Book
Series: Primatologia
Volume: 2
Published: 29 June 1971