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Book Chapter
Series: Chemical Immunology and Allergy
Volume: 94
Published: 10 September 2008
10.1159/000154857
EISBN: 978-3-8055-8629-0
... Abstract Mast cells have been mainly regarded as effector cells in IgE-dependent mucosal immunity, including the host res - ponse to helminthic parasites but also the formidable and sometimes fatal anaphylactic reactions to inhaled or ingested allergens. Work performed mostly within the last...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087644
EISBN: 978-3-318-01232-3
... Abstract It is well established that mast cells are important effector cells mediating the acutephase of IgE-associated allergic disorders, but their roles in late phase reactions andchronic allergic inflammation are not well defined. Here we describe an experimentalapproach for analyzing mast...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 100
Published: 27 May 2014
10.1159/000358733
EISBN: 978-3-318-02195-0
... Abstract The role of mast cells in allergy remained unrevealed until the observation that they contained histamine in 1953, and then the discovery of immunoglobulin E (IgE) in 1966, nearly a century after Ehrlich's first publication. After the discovery of IgE, myeloma-derived IgE from Peter...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 95
Published: 02 June 2010
10.1159/000315937
EISBN: 978-3-8055-9442-4
... Abstract Anaphylaxis is a severe systemic allergic response that is rapid in onset and potentially lethal, and that typically is induced by an otherwise innocuous substance. In IgE-dependent and other examples of anaphylaxis, tissue mast cells and circulating basophilic granulocytes (basophils...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 95
Published: 02 June 2010
10.1159/000315945
EISBN: 978-3-8055-9442-4
... Abstract Human heart mast cells (HHMC), by elaborating vasoactive mediators, cytokines and chemokines, are the main primary effector cells of anaphylaxis. Mast cells have been identified perivascularly, close to myocytes and in the arterial intima in human heart tissue. Mast cells isolated from...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 90
Published: 02 January 2006
10.1159/000088885
EISBN: 978-3-318-01251-4
... Abstract Gut nematode infection induces a dominant type 2 immune response, crypt hyperplasiaand mucosal mastocytosis. Despite their strong association with nematode infection, the roleof mast cells in the mechanism of worm expulsion is yet to be fully defined. Recent worksuggests...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087566
EISBN: 978-3-318-01232-3
... Abstract Human mast cells originated from multipotential hematopoietic progenitors in bonemarrow (BM). A large proportion of these progenitors were CD34 + CD38 - c-kit + cells andCD34 + CD38 + c-kit + cells. Cloning of stem cell factor (SCF) contributed to the developmentof culture systems...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087568
EISBN: 978-3-318-01232-3
... Abstract The cross-linking of FcεRI on mast cells by IgE and antigen (Ag) initiates activationcascades that lead to allergic responses. FcεRI is composed of an α and a Β monomer, anda γ homodimer, and the Β and γ chains possess immunoreceptor tyrosine-based activationmotifs (ITAMs). Through...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087569
EISBN: 978-3-318-01232-3
... to such a classical view, accumulating evidence indicates that uponstimulation of divergent receptor systems, ROS are intentionally produced and even requiredfor appropriate signal transduction and biological responses. Work by our group and that ofothers have shown that stimulation of mast cells through the high...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087570
EISBN: 978-3-318-01232-3
... Abstract The release of pro-inflammatory mediators from mast cells generally occurs followingantigen-dependent aggregation of the high-affinity receptors for IgE (FcεRI) expressed onthe cell surface. Under the appropriate conditions, however, other receptors including thehigh-affinity receptor...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087571
EISBN: 978-3-318-01232-3
... Abstract When activated by diverse stimuli, mast cells mobilize arachidonic acid through cytosolicphospholipase A<inf>2</inf>, and rapidly generate both prostaglandin D<inf>2</inf> and leukotriene C<inf>4</inf>, the parentmolecule of the cysteinyl LTs. While...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087572
EISBN: 978-3-318-01232-3
... Abstract Mast cells specifically localize within the bronchial smooth muscle bundles in patientswith asthma but not in normal individuals. Tryptase and other proteases such as chymase areabundant in mast cell granules and have recently been reported to be involved in the proliferationof airway...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087573
EISBN: 978-3-318-01232-3
... an essential role in tissue remodeling. Recent evidence indicates that chronicasthma may lead to tissue remodeling such as subepithelial fibrosis and extracellular matrix(ECM) deposition in the airways. Recently, the mast cell (MC), which plays a major role inasthma, is found as a novel source of PAI-1...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087574
EISBN: 978-3-318-01232-3
... Abstract It is now well established that human mast cells (MCs) are a source of several multifunctionalcytokines. Preformed immunoreactive tumor necrosis factor-α (TNF-α) has beenobserved within human skin, and pulmonary MC granules are released after IgE-dependentactivation. Recent studies...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087639
EISBN: 978-3-318-01232-3
... Abstract Conventional knowledge tells us that mast cells are only important in the acute IgEmediatedreactions as seen in anaphylaxis, asthma and rhinitis. Yet, in recent years, muchevidence has accumulated on the versatile role of mast cells in allergic inflammation. Here, wedescribe the novel...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087640
EISBN: 978-3-318-01232-3
... Abstract There is a growing interest in the role of chemokines and their receptors in the determinationof mast cell tissue localization and how chemokines regulate mast cell function. Atleast nine chemokine receptors (CXCR1, CXCR2, CXCR3, CXCR4, CX3CR1, CCR1,CCR3, CCR4 and CCR5) have been...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087641
EISBN: 978-3-318-01232-3
... Abstract The human lung mast cell is a crucial effector cell in the mediation of asthma.Activation of mast cells by allergens, and other insults, leads to the elaboration of a widevariety of autacoids that cause bronchoconstriction and promote inflammation. Of the drugsthat are used to treat...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087643
EISBN: 978-3-318-01232-3
... Abstract IgE-dependent activation of human mast cells is a central feature of allergy. However,alternative non-IgE-mediated signals derived from the complex inflammatory milieu are alsoimportant in driving chronic mast cell activation in many tissues. Irrespective of the pointfrom where...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/000087645
EISBN: 978-3-318-01232-3
... in the pathogenesis of the disease, transcriptome assay is now expected as a tool forunderstanding the whole molecule balancing, i.e., system biology. Here I introduce examplesof our trials for understanding the whole functional roles of mast cells as has been publishedin the web database for transcriptomes expressed...
Book
Book Cover Image
Series: Chemical Immunology and Allergy
Volume: 87
Published: 27 June 2005
10.1159/isbn.978-3-318-01232-3
EISBN: 978-3-318-01232-3