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Book Chapter
Series: Translational Research in Biomedicine
Volume: 5
Published: 04 July 2016
10.1159/000444972
EISBN: 978-3-318-05867-3
... and historical perspective in developing mixed chimerism-based tolerance and the transition of using a vascularized bone marrow transplantation (VBMT) strategy from conventional bone marrow transplantation. We elaborate on how the unique characteristics of VBMT with its possession of vascular dependence...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 32
Published: 03 July 2013
10.1159/000346414
EISBN: 978-3-318-02309-1
... Abstract There is increasing evidence that the transplanted bone marrow stromal cells (BMSC) significantly promote functional recovery after central nervous system (CNS) damage in the animal models of various kinds of CNS disorders, including cerebral infarct. However, there remain several...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 32
Published: 03 July 2013
10.1159/000346416
EISBN: 978-3-318-02309-1
... on these observations, we have started cell-based therapy using autologous bone marrow-derived stem/progenitor cells in patients after stroke. This review summarizes the findings of recent experimental and clinical studies that have focused on neurogenesis in the injured brain after cerebral infarction. We also refer...
Book Chapter
Series: Advances in Oto-Rhino-Laryngology
Volume: 72
Published: 10 August 2011
10.1159/000324608
EISBN: 978-3-8055-9723-4
... Abstract Impaired immune regulation along the ‘mucosa-bone marrow axis’ has been postulated to play an important role in the pathogenesis of IgA nephropathy (IgAN). Animal models have allowed us to study such changes in detail. Recently, we established several useful animal models, including...
Book Chapter
Series: Contributions to Nephrology
Volume: 157
Published: 25 May 2007
10.1159/000102307
EISBN: 978-3-318-01467-9
... Abstract Large numbers of studies have demonstrated that abnormal humoral and cellularimmunity may contribute to the pathogenesis of IgA nephropathy. On the other hand, clinicalevidence indicates that bone marrow cells and mucosal immunity may also play a key role.Based on these findings...
Book Chapter
Series: Contributions to Nephrology
Volume: 157
Published: 25 May 2007
10.1159/000102462
EISBN: 978-3-318-01467-9
... Abstract Previous studies indicated that bone marrow cells may contribute to the pathogenesisof IgA nephropathy (IgAN). However, the cell types and mechanisms responsible remainunclear. Our recent study showed that ‘grouped ddY mice’ is a useful model to approachthe pathogenesis of IgAN...
Book Chapter
Series: Monographs in Human Genetics
Volume: 15
Published: 15 May 2007
10.1159/000102549
EISBN: 978-3-318-01461-7
... Abstract Fanconi anemia patients have a high risk for bone marrow failure, aplastic anemia,myelodysplastic syndrome, and acute myeloid leukemia. Many FA patients acquire chromosomalaberrations in their bone marrow (BM) cells. The significance and predictive value ofthese somatic aberrations...
Book Chapter
Series: Monographs in Human Genetics
Volume: 15
Published: 15 May 2007
10.1159/000102550
EISBN: 978-3-318-01461-7
... Abstract Bone marrow (BM) failure in Fanconi anemia (FA) patients followed by myelodysplasticsyndrome or acute myeloid leukemia is frequently associated with the occurrence of specificclonal chromosomal imbalances in BM cells. Our previous data of patients with 3qaberrations revealed that gains...
Book Chapter
Book Chapter
Series: Contributions to Microbiology
Volume: 13
Published: 04 May 2006
10.1159/000092971
EISBN: 978-3-318-01310-8
... Abstract The overall mechanism of bone marrow-derived stem cell (BMDC) trans-differentiationseems to be simple: BMDCs trans-differentiate as referred to the blueprint, which is given bythe tissue itself. Thereby, the blueprint can be the local tissue micro-environment (defined bythe tissue...
Book Chapter
Series: Progress in Respiratory Research
Volume: 33
Published: 04 February 2005
10.1159/000083623
EISBN: 978-3-318-01087-9
Book Chapter