... Abstract Sinonasal malignant mucosal melanoma (SNMM) is a rare, aggressive, and capricious tumour accounting for 4% of sinonasal malignancies. Recent studies suggest an increasing frequency. There are few large published series, but all authors report poor outcomes irrespective of treatment...

... to improve survival outcomes. The overall prognosis remains dismal. Sinonasal malignant tumours are rare, accounting for <3% of all head and neck malignancies. The average age at presentation is in the 5th and 6th decade. There is significant geographical variation along with environmental...

... Abstract The outcome of patients with malignant gliomas has not substantially improved, even with advances in imaging, neurosurgery, molecular subtyping, and radiation, and newer oncologic options. Maximal safe resection when feasible remains the initial treatment of choice for most malignant...

... Abstract Recently, the clinical applications of photodynamic therapy (PDT) in the management of malignant brain tumors have attracted significant attention. Meta-analysis of the observational studies on this treatment in high-grade gliomas (Eljamel, 2010) included more than 1,000 patients...

... Abstract Boron neutron capture therapy (BNCT) is a promising modality for biochemically targeted, highly selective radiation treatment of various cancers, including malignant gliomas. Currently available results demonstrate the beneficial effect of such therapy on survival of patients with both...

... over the last 20 years with better understanding of the biomechanics of infusion and of the delivery process. Though clinical trials of CED in malignant brain tumors have not yielded the desired results, a number of new biologically active compounds and pharmaceutical preparations, their carriers...

... treatment option in cases of intracranial malignant gliomas, whereas future studies should establish its optimal combination with other existing anticancer modalities, which may offer additional survival benefits for patients. Introduction Exposure of cells to non-ionizing, alternating electric...

... and the newly entered one refer to the same aspect of the risk of treatment failure. It is thus understandable that a given prognostic variable (e.g. clinical grade of malignancy) that is important in one study does not appear in the multivariate model in another study where the final model is composed of other...

... Abstract The successful treatment of salivary gland malignancies originating in the parotid gland begins with rigorous and thorough surgical management coupled with the directed and appropriate potential adjuvant use of radiation therapy and chemotherapy. The anatomic complexity of the region...

... Abstract For many decades, surgery has been the primary treatment for malignant submandibular gland neoplasms. Nonetheless, due to the heterogeneity and rarity of submandibular gland malignant tumors and the high frequency of chronic benign processes in this region, management can be complex...

... Abstract Malignant sublingual gland neoplasms are rare, early-stage neoplasms presenting as painless non-ulcerated masses in the antero-lateral floor of the mouth. The majority of patients present with advanced disease, with symptoms of pain or anaesthesia of the tongue. Malignant minor...

... of the use of combined therapy for treatment of the N+ neck in salivary gland cancers look promising, they still leave a lot to be desired [ 10 , 17 ]. In analysis of malignant tumors of major salivary gland origin, Armstrong et al. found a 5-year local-regional control rate of 69% for a group of 23 patients...

... Abstract For patients with inoperable salivary gland malignancy, radiation therapy has significant limitations but has been the mainstay of treatment. With standard photon radiation (X-rays), the 10-year loco-regional control (LRC) and overall survival rates are only ∼25%. Neutron radiation has...

... Abstract The management of malignant salivary gland neoplasms is based on a surgical paradigm, with intraoperative findings and pathology guiding the role of local-regional adjuvant therapy. Despite high rates of local control, local relapse can be a dominant pattern of recurrence, presenting...

... to yield best possible outcomes. Due to space limitations, this chapter will focus on CRD and intra-arterial chemotherapy for retinoblastoma. Chemotherapy for intraocular malignancies has evolved since 1953, when nitrogen mustard was first used to treat retinoblastoma [ 1 ]. Due to space...

... Abstract The main indication for esophageal dilation is to relieve benign or malignant dysphagia. Endoscopic dilation of malignant strictures is also performed to facilitate the completion of endoscopic procedures, such as endoscopic ultrasonographic tumor staging and to permit the placement...