... function and/or expression have been identified. All these mutations are associated with cystic fibrosis (CF), which causes chronic lung infections and inflammation resulting in respiratory failure and digestive disorders. Some of these mutations have been identified in non-CF patients presenting male...

... and need further evidence from randomized clinical trials. Introduction Male hypogonadism (HG) is a medical condition resulting from either an absent or an inadequate and an impaired secretion of hypothalamic gonadotropin-releasing hormone (GnRH) or of pituitary gonadotropins (follicular...

... Abstract Male and female infertility affects close to 50 million couples worldwide according to a recent World Health Organization estimate. Many of the 25-30% of couples with idiopathic infertility likely have a genetic etiology for their condition. Next-generation sequencing has identified...

... Abstract In the euchromatic part of the long arm of the human Y chromosome (Yq11) at least 13 Y genes encoding proteins and expressed in male germ cells were found in 3 distinct genomic Y regions frequently deleted in infertile men with idiopathic azoospermia, i.e., for unknown reasons...

... Abstract The androgen testosterone has an essential trophic role in the development of male physiology and in adult spermatogenesis and fertility. Testosterone mainly exerts its effect through the androgen receptor (AR), a ligand-activated transcription factor that is activated by binding...

... point of spermiogenesis lead to a reduced ability to conceive offspring due to either a reduced number or abnormal morphology and function of spermatozoa. Defective spermatozoa are often observed in infertile males, including sperm with an abnormal morphology (teratozoospermia), defective motility...

... of the haploid male and the female gametes completes the cycle of the germline and begins the next generation (Fig. 1 ). This sequence of events occurs in all mammals. However, different species exhibit specific adaptations and characteristics of 1 or more phases of the cycle of the germline. Remarkably...

... provides half of the genetic material and epigenetic information that is needed to create a new life upon fertilization. Due to its intricacy, germ cell differentiation is error prone and problems at all stages of spermatogenesis might contribute to human infertility. Male infertility accounts for half...

... Abstract Male delayed puberty is common, affecting up to 3% of the population. Management of patients with pubertal delay is dependent on the underlying cause. The main differential diagnoses of delayed puberty in males include constitutional delay of growth and puberty (CDGP), idiopathic...

...) is monitored by making comparisons with reference percentiles where the 50th percentile represents the average size at any chronological age. Young male athletes in most sports (e.g. swimming, tennis, ice hockey, rowing) are generally taller than their non-athletic peers although in some sports...

... Abstract Infertility in the male is a potential complication of childhood cancer treatment for long-term survivors. The risk is dependent primarily on the treatment used, but also on the underlying disease. Chemotherapy (especially alkylating agents) and radiotherapy, even in low doses, may...