... (bilateral adrenocortical hyperplasias,BAHs): micronodular adrenal disease and its pigmented variant, primary pigmented nodular adrenocorticaldisease are mostly genetic processes. Macronodular BAHs, ACTH-independent macronodular hyperplasia ormassive macronodular adrenocortical disease are less frequently...

... Abstract Primary adrenal hypercortisolism is mainly due to cortisol-producing adrenocortical adenomas, bilateral micronodular or macronodular disease, and adrenal carcinomas. Important advances in the pathophysiology of primary adrenal hypercortisolism have been made in the last few years...

..., Bertagna X, Bertherat J, Groussin L: Aberrant cortisol regulations in bilateral macronodular adrenal hyperplasia: a frequent finding in a prospective study of 32 patients with overt or subclinical Cushing's syndrome. Eur J Endocrinol 2010;163:129-138. 11. Reznik Y, Lefebvre H, Rohmer V, Charbonnel B...

.... Liver with irregular profiles and macronodular degeneration. White arrow = portal vein. f Portal vein flow. Splenomegaly and ascites indicates a mild portal hypertension. L = Liver. In HRS, renal failure is triggered by a marked vasoconstriction that occurs with not well identified mechanisms...

... adenomas, 5% adrenal carcinomas and a few rare conditions including macronodular adrenal hyperplasia, McCune-Albright syndrome and primary pigmented nodular adrenal disease [ 3 ]. The difficulty in the diagnosis of Cushing's syndrome is discriminating the condition from others where the hypothalamic...

... F, Lefebvre H, Barrande G, Ajzenberg C, Tauveron I, Clauser E, Dousset B, Bertagna X, Bertherat J, Groussin L: Aberrant cortisol regulations in bilateral macronodular adrenal hyperplasia: a frequent finding in a prospective study of 32 patients with overt or subclinical Cushing’s syndrome. Eur J...

..., Barreau O, Lefevre L, Sibony M, Guignat L, Rodriguez S, Perlemoine K, Rene-Corail F, Letourneur F, Trabulsi B, Poussier A, Chabbert-Buffet N, Borson-Chazot F, Groussin L, Bertagna X, Stratakis CA, Ragazzon B, Bertherat J: ARMC5 mutations in macronodular adrenal hyperplasia with Cushing's syndrome. N Engl...

... aneurism at age 36, a cured female with CD aged 38 from mesenteric thrombosis, and another cured female with CD suffered a sudden cardiac death at age 55. The other 2 patients (one noncured female with ectopic ACTH secretion and one cured female with bilateral macronodular hyperplasia) died at age 56 from...

... ovary syndrome in women taking valproate for epilepsy. Epilepsy Res 2011;97:73–82. 75. Goodarzi MO, et al: Virilization in bilateral macronodular adrenal hyperplasia controlled by luteinizing hormone. J Clin Endocrinol Metab 2003;88:73–77. 76. Kassi E, et al: Current issues in the diagnosis...

... cortisol regulations in bilateral macronodular adrenal hyperplasia: a frequent finding in a prospective study of 32 patients with overt or subclinical Cushing’s syndrome. Eur J Endocrinol 2010;163:129–138. 33. Tóth M, Rácz K, Adleff V, Varga I, Fütö L, Jakab C, Karlinger K, Kiss R, Gláz E: Comparative...

... hyperandrogenism also in post-menopause. Interestingly, there have been described a few cases with unilateral adrenal adenoma or bilateral macronodular hyperplasia, in which adrenal androgens responded to hCG or LH stimulation, due to the presence of aberrant LHRs. In most cases adenomas were secretory...

... primary adrenal hypercortisolism (primary pigmented nodular adrenocortical disease and ACTH-independent macronodular adrenocortical hyperplasia) [ 22 ]. Unexpectedly, up to 10% of patients experience recurrence years after bilateral adrenalectomy, due to adrenal remnants or accessory glands. A recent...

... adenoma, adrenal carcinoma, or macronodular or micronodular adrenal hyperplasia in 20-25% of cases. Rarely (around 5% of all cases), endogenous hypercortisolism is the consequence of ectopic oversecretion of ACTH (or very rarely CRH) from extra pituitary tumors (generally of neuroendocrine origin) [ 1 , 2...