... Abstract With the growing prevalence of acute liver failure or acute-on-chronic liver failure, on the one hand, and the limited supply of liver organs for transplantation, on the other hand, it is critical to the design, validate, and implement devices that can provide extracorporeal liver...

... Abstract Modern advances in medicine have meant that young people with liver disease now have the opportunity to live into adolescence and adulthood. However, this comes at a cost; regular trips to doctors/hospital and often a regime of lifelong daily medication. Traditional models of medicine...

... Abstract Liver failure in the intensive care unit (ICU), whether acute or acute-on-chronic, remains a serious condition with reduced functions, various metabolite and toxin accumulation in the systemic circulation, and a high mortality rate. While transplantation remains the treatment of choice...

... Cholestasis Fat Fat-soluble vitamins Nutritional assessment Key Messages Children with cholestatic liver disease require aggressive nutritional management to prevent growth failure, malnutrition, and deficiencies. Specific diagnostic tools are indicated to monitor nutritional...

...Key Messages Define parenteral nutrition-associated cholestasis and intestinal failure-associated liver disease. Review population characteristics, clinical risk factors, and diagnostic algorithms. Appraise the evidence for the prevention and management of disease with a focus...

... is associated with increased morbidity and mortality in patients with cirrhosis, and it has also been associated with increased complications after liver transplantation. Currently, the management of hypervolemic hyponatremia in cirrhosis is based on fluid restriction. Vaptans, oral selective vasopressin V2...

... liver failure, with a complete recovery of liver function in a patient after severe cholangitis and relapsing hemolytic anemia. The resin enabled the removal of bilirubin and protein-bound toxins, while the hemofilter removed the hydrophilic toxins such as ammonia and non-protein-bound toxins as free...

... Abstract The chronic nature of liver diseases in children and adults merits close follow-up for disease progression and/or treatment evaluation. Disease progression involves injury to liver cells resulting in cell death, varying degrees of inflammation, steatosis depending on the insult...

... Abstract Nonalcoholic fatty liver disease (NAFLD) is one of the most important causes of chronic liver disease in children and adults. Recently, therapeutic supplementation with docosahexaenoic acid (DHA) showed an anti-inflammatory and insulin-sensitizing effect in children with NAFLD...