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Book Chapter
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 95
Published: 12 January 2021
10.1159/000511515
EISBN: 978-3-318-06866-5
.... In laboratory settings, repeated exposure is effective in promoting children’s acceptance and consumption of novel foods. We have recently explored mother and child early experiences (from infancy to toddlerhood) with offering hard-to-like foods. Our findings suggest a “sweet spot” for food introduction...
Book Chapter
Book Chapter
Series: Frontiers of Hormone Research
Volume: 48
Published: 09 March 2017
10.1159/000452913
EISBN: 978-3-318-06014-0
... Abstract Most scientific reports debate the thymotropic and immuno-stimulating properties of the somatotrope growth hormone-releasing hormone (GHRH)/growth hormone (GH)/insulin-like growth factor (IGF)-1 axis, but there is still some disagreement about the physiological role of this axis...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 47
Published: 30 June 2016
10.1159/000445147
EISBN: 978-3-318-05869-7
... Abstract This chapter addresses what is known about the endocrine system components growth hormone (GH)-insulin-like growth factor (IGF) axis, thyroid axis, and prolactin relative to exercise and exercise training. Each one of these hormone axes contributes to the maintenance of homeostasis...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 47
Published: 30 June 2016
10.1159/000445173
EISBN: 978-3-318-05869-7
.... There is a significant amount of anecdotal evidence that human GH is misused by athletes to enhance performance, and there have been a number of high-profile cases of GH use in professional sport. GH secretagogues (GH-Ss), which increase GH secretion, and insulin-like growth factor (IGF-1), which mediates many...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 46
Published: 23 May 2016
10.1159/000443915
EISBN: 978-3-318-05840-6
... only from GC deficiency, as aldosterone and adrenal androgens secretion is preserved. Moreover, SAI rarely manifests with an acute adrenal crisis, although acute presentation can be precipitated by stress like surgery, trauma or infection [ 24 ]. At the same time, patients can present with some...
Book Chapter
Series: Endocrine Development
Volume: 30
Published: 10 December 2015
10.1159/000439323
EISBN: 978-3-318-05637-2
... among adults. Among these, glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment appears to have reasonable weight loss efficacy along with other beneficial pleiotropic effects. Although larger trials will be required to confirm the results, two small pediatric clinical trials have suggested...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 34
Published: 09 July 2015
10.1159/000381583
EISBN: 978-3-318-05474-3
... complications, the new onset of paradoxical inflammation of the skin and other organs can occur in patients on anti-TNF therapy. The inflammatory bowel disease literature reports an increasing prevalence of paradoxical psoriasis. Less often, anti-TNF-induced lupus-like drug reactions with concomitant cutaneous...
Book Chapter
Series: Frontiers of Gastrointestinal Research
Volume: 34
Published: 09 July 2015
10.1159/000381592
EISBN: 978-3-318-05474-3
... rare disease entity, occurring in a minority of up to 2% of these patients. A diagnosis of anti-TNF drug-induced lupus is likely for patients presenting with symptoms including arthralgia, myalgia, fever, serositis, nephritis, vasculitis and dermatological rash occurring at least 1 month after...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 43
Published: 12 June 2014
10.1159/000360571
EISBN: 978-3-318-02674-0
... indicates that insulin-like growth factor-1 exerts antioxidant, anti-inflammatory and pro-survival effects on the vasculature, reducing atherosclerotic plaque burden and promoting features of atherosclerotic plaque stability. Initial results from experiments employing the endothelial denudation...
Book Chapter
Series: Else Kröner-Fresenius Symposia
Volume: 4
Published: 05 June 2013
10.1159/000346535
EISBN: 978-3-318-02348-0
... ]. Dysregulation of miRNAs can impact on a wide variety of conditions, from cancer [ 9 , 10 ] to cardiovascular disease [ 10 ], and inflammatory and autoimmune diseases [ 11 , 12 ]. Toll-like receptors, of which TLR1-9 have been characterized extensively in mammalian cells, are at the front line of defense...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 106
Published: 12 February 2013
10.1159/000342577
EISBN: 978-3-318-02266-7
... concentrations on growth physiology will also be discussed. Role of IGF-1 in Human Linear Growth The human insulin-like growth factors (IGFs) are small single chain peptides of 7.5 kDa composed of 70 amino acids for IGF-1 and 67 amino acids for IGF-2. This chapter will concentrate on IGF-1 which...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 106
Published: 12 February 2013
10.1159/000342546
EISBN: 978-3-318-02266-7
... Abstract Information about the role of insulin-like growth factors (IGFs) is mainly derived from knockout (KO) and transgenic mice, human mutations in IGF1 , IGF1R and IGFALS , and association studies with IGF1 SNPs. Igf1 KO mice show severely impaired pre- and postnatal growth...
Book Chapter
Series: World Review of Nutrition and Dietetics
Volume: 106
Published: 12 February 2013
10.1159/000342555
EISBN: 978-3-318-02266-7
... of developing obesity. However, some studies suggest that weight gain during the 6- to 12-month age period, when complementary feeding is introduced, is not associated with later obesity. Insulin-like growth factor-1 (IGF-1) values and body composition both play a role in the complex pattern between early diet...
Book Chapter
Series: Endocrine Development
Volume: 23
Published: 26 November 2012
10.1159/000341739
EISBN: 978-3-318-02245-2
... and a serum IGF-1 <–2 appears sufficient to perform genetic tests for known candidate genes. Insulin-like growth factors (IGFs) include two related proteins: IGF-1 and IGF-2. The term IGF deficiency (IGFD) usually refers to a deficiency of IGF-1. There are only few reports on a deficiency of serum...
Book Chapter
Series: Endocrine Development
Volume: 23
Published: 26 November 2012
10.1159/000341745
EISBN: 978-3-318-02245-2
... Abstract Until 10 years ago genetic defects that cause a child to be born small for gestational age (SGA) were poorly defined. With the first descriptions of patients born small for gestational age carrying mutations within the insulin-like growth factor type 1 receptor (IGF-1R) gene, genetic...
Book
Book Cover Image
Published: 25 April 2012
10.1159/isbn.978-3-8055-9969-6
EISBN: 978-3-8055-9969-6
Book Chapter
Book Chapter
Series: Current Problems in Dermatology
Volume: 41
Published: 09 May 2011
10.1159/000323295
EISBN: 978-3-8055-9687-9
...) in the skin of patients with AD. Allergen binding is most likely by the high-affinity receptor for IgE (FcΕRI), which is highly expressed by epidermal DCs in AD. Beyond, pattern recognition receptors such as Toll-like receptors (TLRs) sense the environment for pathogen-associated molecular patterns. Combined...