... Abstract Certain structurally abnormal light and heavy chains are known to be nephrotoxic and altermesangial homeostasis producing pathological alterations. Many of the mechanisms involved inlight chain-mesangial interactions have been deciphered using an in vitro model, providing aframework...

... and potentially also in systemic immunosuppression, which may not only impair control of dysplastic and neoplastic skin lesions but also affect immuno­pathological and infectious skin diseases. Recent find­ings have shown that ambient doses of high-energy visible light, beyond the UV range, may also cause damage...

... radiation. Recently, there has been increasing evidence to suggest that less energetic radiation, such as visible light and infrared radiation, might also influence skin physiology. Yet, it remains unclear, regarding risk assessment, whether visible light irradiation induces positive or negative effects...

... Abstract Infrared light (760 nm–1 mm) constitutes approximately 40% of the solar radiation reaching the ground at sea level. Shortest wavelength near-infrared (NIR) photons (NIR or IR-A: 760–1,400 nm) can penetrate the epidermis, dermis, and subcutaneous tissue with numerous biological effects...

... dissociation. In 2 other fields, Head’s contributions were also outstanding: he shed new light on spinal reflex functions, notably on the nature of the stimulus. His collaboration with Gordon Holmes (1876–1965) led to the first accurate account of the functions of the optic thalamus and its relation...

... Abstract Intense pulsed light (IPL) is a high-intensity, polychromatic, noncoherent light source used to treat a variety of skin conditions. It is frequently used to treat vascular lesions using the principles of selective photothermolysis, and it is often the technique of choice due to its...

... is subject to attacks of epilepsy, separated by long intervals, and that it is advisable to place him under long-term observation in the institution.’ If one analyses the sources for description of the symptoms carefully in the light of modern insights into epilepsy, one must doubt the accuracy...

... Abstract With the advancement in laser technology, there has been a recent trend in laser and light devices towards ‘do it yourself’ at-home use. There has been an exponential growth in devices aimed at the treatment of acne, hair removal, and psoriasis. With the exception of the at-home UVB...

... Abstract In addition to lasers, intense pulsed light (IPL) sources are widely used in medicine to treat various indications, such as vascular lesions, irregular pigmentation and hypertrichosis. In contrast to lasers, IPL systems are broadband flash lamps that emit polychromatic incoherent light...

... Abstract Light-emitting diode (LED) photomodulation has become a recognized player in the world of lasers and light sources. It is used to treat a variety of clinical entities, including photorejuvenation, erythema-induced injury following laser and other cosmetic procedures, and acne vulgaris...

... Abstract Light, light and heavy, and heavy chain deposition diseases (LCDD, LHCDD and HCDD, respectively) belong to a family of diseases featuring deposition in the kidney of a monoclonal immunoglobulin (Ig) or its isolated subunits, which also includes light chain amyloidosis, non-amyloid...

... Abstract Immunoglobulin light chains are low molecular weight proteins that are filtered through the glomerulus and reabsorbed into the proximal tubular epithelium by binding initially to a heteromeric receptor complex composed of megalin and cubilin. Saturation of this receptormediated...