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Book Chapter
Series: Frontiers of Hormone Research
Volume: 46
Published: 23 May 2016
10.1159/000443918
EISBN: 978-3-318-05840-6
... Abstract For a long time it has been assumed that patients with chronic adrenal insufficiency under established replacement therapy have a normal life expectancy and a normal everyday life. Recent studies now indicate both an impairment of quality of life (QoL) with a negative impact on daily...
Book Chapter
Series: Current Problems in Dermatology
Volume: 44
Published: 28 May 2013
10.1159/000350007
EISBN: 978-3-318-02404-3
... Abstract Social and behavioral scientists have long been interested in cumulative, life course processes. This chapter reviews prototypical questions and methods from the life span approach in psychology as well as the life course approach in sociology. Their relevance for understanding...
Book Chapter
Series: Current Problems in Dermatology
Volume: 44
Published: 28 May 2013
10.1159/000350385
EISBN: 978-3-318-02404-3
... and timing of exposure over the life course. These aspects have become particularly relevant in the field of chronic diseases such as chronic dermatological conditions, where complete healing is unlikely to occur. Two key concepts may aid understanding of chronic medical conditions in a more comprehensive...
Book Chapter
Series: Current Problems in Dermatology
Volume: 44
Published: 28 May 2013
10.1159/000350781
EISBN: 978-3-318-02404-3
... Abstract The concepts of cumulative life course impairment (CLCI) and health-related quality of life (QoL) are analyzed, in order to find shared and divergent aspects. The concept of QoL includes the patients' perception of their health and their personal experiences concerning the psychosocial...
Book Chapter
Series: Current Problems in Dermatology
Volume: 44
Published: 28 May 2013
10.1159/000350389
EISBN: 978-3-318-02404-3
... Abstract Chronic diseases can severely impair patients' quality of life but little information is available about the long-term impact of chronic diseases. The chronic nature of disease may decrease patients' psychosocial well-being, may change their attitude towards life goals and influence...
Book
Book Cover Image
Series: Forum of Nutrition
Volume: 45
Published: 13 June 1990
10.1159/isbn.978-3-318-03603-9
EISBN: 978-3-318-03603-9
Book Chapter
Book Chapter
Book Chapter
Series: Monographs in Oral Science
Volume: 32
Published: 20 August 2024
10.1159/000538873
EISBN: 978-3-318-07248-8
... Abstract Oral health-related quality of life (OHRQoL) is a multifaceted concept that surpasses an exclusively clinical perception and includes functional, social, emotional, and environmental issues. The measure of OHRQoL represents a holistic approach for research and clinical practice...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 99
Published: 29 May 2024
10.1159/000534961
EISBN: 978-3-318-07336-2
... aspects of the immune system are poorly developed at birth indicating the importance of passive immunity from the mother (e.g., via breast milk) and immune maturation occurs over the first months to years of life. This maturation occurs alongside gut maturation and acquisition of a mature microbiome...
Book
Book Chapter
Series: Monographs in Oral Science
Volume: 31
Published: 19 July 2023
10.1159/000530614
EISBN: 978-3-318-07166-5
... Abstract Dental caries is the most prevalent oral health disease and affects the health of individual and populations. The conventional disease metrics do not represent the impact of caries on people’s lives. Oral-health-related quality of life measures were developed to help understand which...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 97
Published: 12 May 2023
10.1159/000528988
EISBN: 978-3-318-07170-2
... of life has been linked to short- and long-term health outcomes. Characterizing optimal maturation of the ecosystem may help identifying adverse events that impair the process and also factors that support and guide it, such as diet. To date, researchers have looked at the evolution over time of gut...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 96
Published: 30 June 2022
10.1159/000519383
EISBN: 978-3-318-07015-6
... Abstract Stress exposure during sensitive developmental periods lastingly affects brain function and cognition and increases vulnerability to psychopathology later in life, as established in various preclinical and clinical studies. Interestingly, similar patterns are seen in children who...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522449
EISBN: 978-3-318-07054-5
... of the subjects (Fig.  1 a, b). On inquiry of what has happened to those patients, I was told that all of them have since passed away. This serendipitous finding prompted the initiation of a series of studies that led us to the identification of a life-and-death signal that reflects the functionality of the brain...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522458
EISBN: 978-3-318-07054-5
... The observations that a biomarker of life and death undergoes augmentation followed by reduction and disappearance during the progression towards brain stem death in experimental animal models open the vista to search for both pro-life and pro-death cellular and molecular programs...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522460
EISBN: 978-3-318-07054-5
... ]. Given that death posts the most severe threat to existence, we undertook a series of studies in early 2000s on HSPs, and found that at least HSP60 and HSP70 in the rostral ventrolateral medulla (RVLM) play a pro-life role during brain stem death. 6.1. Heat Shock Proteins as Molecular Chaperones...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522461
EISBN: 978-3-318-07054-5
... associated with brain stem death. We further found that the repertoire of oxygen-sensitive gene products activated by hypoxia in the RVLM during the pro-life phase of brain stem death may entail sequential activation of HIF-1, heme oxygenase-1 (HO-1), and heat shock protein 70 (HSP70), leading...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522463
EISBN: 978-3-318-07054-5
... (see Chapters 4, 7, and 8), are among the many transcription factors that are sumoylated. Subsequent experiments from our group confirmed that sumoylation of HIF-1α and NF-κB in the rostral ventrolateral medulla (RVLM) plays a pro-life role during brain stem death. 9.1. Conjugation Like...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 8
Published: 10 May 2022
10.1159/000522464
EISBN: 978-3-318-07054-5
... time, phosphatase and tensin homolog (PTEN), a well-documented tumor suppressor [ 18, 19 ], plays a pro-life role as a negative regulator of PI3K/Akt signaling in the RVLM. 10.1. PI3K/Akt Signaling Cascade PI3K can be divided into class I, II, and III subfamilies based on structure, substrate...