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leptospirosi

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Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
10.1159/000527571
EISBN: 978-3-318-07124-5
... Abstract Leptospirosis is the most common zoonosis frequently seen in the tropics and subtropics especially during the rainy season when humans wade in floods contaminated by the urine of infected rats in urban areas. Aside from direct toxicity of the leptospires, the role of an exuberant...
Book
Book Cover Image
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/isbn.978-3-318-06540-4
EISBN: 978-3-318-06540-4
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500376
EISBN: 978-3-318-06540-4
... Abstract Leptospirosis is one of the main causes of tropical infections causing acute kidney injury (AKI). These infections commonly relate to the low socioeconomic status and humid climate. Leptospires modified their membrane transport for cell volume regulation and acid – base control...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500387
EISBN: 978-3-318-06540-4
... Abstract Severe leptospirosis can cause acute kidney injury, but whether leptospiral infection can lead to chronic kidney disease (CKD) remains inconclusive. Chronic leptospirosis has been discovered in animals and characterized as tubulointerstitial fibrosis with tubular atrophy. In human...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500378
EISBN: 978-3-318-06540-4
... Abstract Leptospirosis is the most widespread zoonosis globally and is caused by Leptospira interrogans . Its major animal hosts include rodents, dogs, cattle, sheep, pigs, and rabbits. Leptospirosis is a global public health issue, characterized by a sudden onset of fever, myalgia...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500380
EISBN: 978-3-318-06540-4
... Abstract Leptospirosis is the most prevalent zoonosis affecting more than 1 million people worldwide. Acute leptospirosis induces multiple organ dysfunctions including acute kidney injury. Interestingly, the endemic regions of leptospirosis coincide with chronic kidney disease of unknown (CKDu...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500379
EISBN: 978-3-318-06540-4
... Abstract Acute kidney injury (AKI) is a prominent feature of leptospirosis, characterized by tubulo-interstitial nephritis and tubular dysfunction. Nonoliguric hypokalemic form of AKI is a hallmark of leptospiral nephropathy. Arrhythmias are the most important cardiac manifestations...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500381
EISBN: 978-3-318-06540-4
... Abstract Leptospirosis is an important global zoonotic disease. It is endemic in many regions with large epidemics occurring after heavy rainfall and flooding. It is also a notable occupational infection. Infection occurs from direct contact with infected urine from carrier animals...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500382
EISBN: 978-3-318-06540-4
... Abstract Pathogenic species of Leptospira cause leptospirosis, a global zoonotic disease. The kidney is the main target of Leptospira during both acute and chronic infections, as the conditions in the renal tubules favor Leptospira survival. Acute kidney injury with characteristic...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500388
EISBN: 978-3-318-06540-4
... Abstract Leptospirosis is a worldwide neglected zoonosis caused by the bacterium Leptospira interrogan s. These spirochetes are widespread pathogens able to infect virtually all vertebrates. They may colonize the kidneys of their hosts, as in rodents, which are a common, asymptomatic reservoir...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500389
EISBN: 978-3-318-06540-4
... Abstract Leptospirosis is an infectious disease caused by exposure to pathogenic leptospires in contaminated water or soil. Invasion and colonization by leptospires may cause multiple organ failure, including severe kidney injury, in infected patients. However, the detailed mechanisms...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500390
EISBN: 978-3-318-06540-4
... between leptospirosis and kidney disease. Several methods are applied to determine the protein structure including X-ray crystallography, small-angle X-rays scattering, nuclear magnetic resonance, and electron microscopy (EM). The advantages and applications of these technologies will further be discussed...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500391
EISBN: 978-3-318-06540-4
... Abstract Leptospirosis, an infectious disease caused by pathogenic Leptospira spp., has reemerged in recent years and caused increased incidences of public health problems. Leptospirosis has clinical manifestations ranging from asymptomatic infections to severe presentations involving...
Book Chapter
Series: Contributions to Nephrology
Volume: 200
Published: 07 August 2023
EISBN: 978-3-318-07124-5
...References References 1. Pasamba EM, Arakama MI, Danguilan RA, Mendoza MT. Outcome of adults with leptospirosis and renal failure treated with pulse immunosuppression. J Kidney. 2018;4:161. 2. Taylor AJ, Paris DH, Newton PN. A systematic review of the mortality for untreated leptospirosis...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
10.1159/000500375
EISBN: 978-3-318-06540-4
... Leptospirosis is a most common zoonotic disease worldwide, particularly in tropical and sub-tropical regions where flooding frequently occurs. When Leptospira infects animals, kidneys are the preferential site where Leptospira accumulates, in the interstitium and in renal tubule epithelial...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
EISBN: 978-3-318-06540-4
...References References 1. Levett PN: Leptospirosis. Clin Microbiol Rev 2001;14:296–326. 2. Yang HY, Hsu PY, Pan MJ, Wu MS, Lee CH, Yu CC, Hung CC, Yang CW: Clinical distinction and evaluation of leptospirosis in Taiwan – a case-control study. J Nephrol 2005;18:45–53. 3. Yang HY, Yen TH...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
EISBN: 978-3-318-06540-4
...References References 1. Costa F, Hagan JE, Calcagno J, Kane M, Torgerson P, Martinez-Silveira MS, Stein C, Abela-Ridder B, Ko AI: Global morbidity and mortality of leptospirosis: a systematic review. PLoS Negl Trop Dis 2015;9:e0003898. 2. Pappas G, Papadimitriou P, Siozopoulou V...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
EISBN: 978-3-318-06540-4
...References References 1. Levett PN: Leptospirosis. Clin Microbiol Rev 2001;14:296–326. 2. World Health Organization: Human Leptospirosis: Guidance for Diagnosis, Surveillance and Control, 2003. www.who.int/csr/don/en/WHO_CDS_CSR_EPH_ 2002.23.pdf. 3. Gompf SG: Leptospirosis. https...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
EISBN: 978-3-318-06540-4
... killer. Kidney Int 2013;84:457–467. 3. Bellomo R, Kellum JA, Ronco C: Acute kidney injury. Lancet 2012;380:756–766. 4. Yang CW, Pan MJ, Wu MS, Chen YM, Tsen YT, Lin CL, Wu CH, Huang CC: Leptospirosis: an ignored cause of acute renal failure in Taiwan. Am J Kidney Dis 1997;30:840–845. 5...
Book Chapter
Series: Translational Research in Biomedicine
Volume: 7
Published: 09 September 2019
EISBN: 978-3-318-06540-4
... disease. Lancet 2010;375:1296–1309. 3. Bharti AR, Nally JE, Ricaldi JN, Matthias MA, Diaz MM, Lovett MA, Levett PN, Gilman RH, Willig MR, Gotuzzo E, Vinetz JM; Peru-United States Leptospirosis Consortium: Leptospirosis: a zoonotic disease of global importance. Lancet Infect Dis 2003;3:757–771. 4...