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leptin

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Book Chapter
Series: Forum of Nutrition
Volume: 63
Published: 10 December 2009
10.1159/000264400
EISBN: 978-3-8055-9301-4
... Abstract Leptin acts as an anorexigenic hormone in the brain, where the long form of the leptin receptor (LRb) is widely expressed in hypothalamic and extra-hypothalamic sites that are known to participate in diverse feeding circuits. The important role of leptin in energy homeostasis...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 48
Published: 09 March 2017
10.1159/000452908
EISBN: 978-3-318-06014-0
... Abstract Hypothalamic resistance to adipostatic actions of leptin is a hallmark of obesity. Studies have revealed that hypothalamic inflammation, triggered in response to the consumption of large amounts of dietary fat, is an important mechanism in the development of leptin resistance...
Book Chapter
Series: Chemical Immunology and Allergy
Volume: 99
Published: 21 October 2013
10.1159/000353557
EISBN: 978-3-318-02481-4
... of the adipose tissue-derived hormone leptin has shed fundamental insights on how these processes might occur. Leptin represents a link among metabolic disorders and immune tolerance; indeed, leptin can negatively affect the generation and proliferation of Treg cells, key players in this context. Treg cells play...
Book Chapter
Series: Nestlé Nutrition Institute Workshop Series
Volume: 65
Published: 11 February 2010
10.1159/000281143
EISBN: 978-3-8055-9305-2
... to neurons within the arcuate nucleus of the hypothalamus (ARH). The ARH has long been associated with obesity and contains neurons that respond directly to a variety of hormonal and nutrient signals, including leptin, insulin, ghrelin, amino acids, and glucose [ 3 ]. The ARH contains a collection...
Book Chapter
Series: Forum of Nutrition
Volume: 63
Published: 10 December 2009
10.1159/000264399
EISBN: 978-3-8055-9301-4
... Abstract The physiological regulation of adiposity is supposed to depend on endocrine ‘adiposity signals’ that inform the brain about the mass of the adipose tissue. Basal levels of insulin and leptin are widely accepted to be adiposity signals, and amylin, ghrelin and peptide YY have been...
Book Chapter
Series: Endocrine Development
Volume: 17
Published: 24 November 2009
10.1159/000262530
EISBN: 978-3-8055-9303-8
... thyroid hormone and growth hormone (and its downstream product, IGF-1). At adolescence there is the reawakening of the hypothalamic-pituitary-gonadal axis and its interaction with the GH/IGF-1 axis to subserve the pubertal growth spurt. The fat tissue-derived hormone, leptin and its receptor are likely...
Book Chapter
Series: Contributions to Nephrology
Volume: 151
Published: 17 August 2006
10.1159/000095326
EISBN: 978-3-318-01384-9
... Abstract Leptin is a 16-kDa protein produced mainly by adipocytes. Animal models demonstratethat leptin is required for control of bodyweight and reproduction, since mice defective inleptin or the leptin receptor are obese, hyperphagic insulin resistant and infertile. Our initialseries...
Book Chapter
Series: Contributions to Nephrology
Volume: 151
Published: 17 August 2006
10.1159/000095328
EISBN: 978-3-318-01384-9
... Abstract Leptin is a peptide hormone that is mainly, but not exclusively, produced in adipose tissueand plays a pivotal role in regulating food intake and energy expenditure. Besides its effects onregulation of body weight, appetite and energy expenditure, leptin exhibits influence on theimmune...
Book Chapter
Book Chapter
Series: Frontiers in Diabetes
Volume: 17
Published: 27 July 2005
10.1159/000087402
EISBN: 978-3-318-01214-9
Book Chapter
Book Chapter
Series: Frontiers of Hormone Research
Volume: 26
Published: 20 December 1999
10.1159/000061013
EISBN: 978-3-318-00467-0
Book Chapter
Book Chapter
Series: Frontiers of Hormone Research
Volume: 26
Published: 20 December 1999
10.1159/000061020
EISBN: 978-3-318-00467-0
Book Chapter
Series: Frontiers of Hormone Research
Volume: 26
Published: 20 December 1999
10.1159/000061014
EISBN: 978-3-318-00467-0
Book Chapter
Series: Frontiers of Hormone Research
Volume: 26
Published: 20 December 1999
10.1159/000061015
EISBN: 978-3-318-00467-0
Book Chapter
Book Chapter
Book Chapter
Series: Frontiers of Hormone Research
Volume: 26
Published: 20 December 1999
10.1159/000061018
EISBN: 978-3-318-00467-0
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Series: Frontiers of Hormone Research
Volume: 26
Published: 20 December 1999
10.1159/isbn.978-3-318-00467-0
EISBN: 978-3-318-00467-0