... with an arrested cell cycle and decreased expression of Klotho protein. Because cell cycle arrest has a protective effect on organs in the acute phase, the proposed therapeutic target against the aging process is to maintain expression of Klotho protein. In addition, it is recognized that TGF-β 1 plays a central...

... Abstract The sequential bone disorders, serum parameter abnormalities and vascular calcification that are associated with chronic kidney disease (CKD) have come to be generally known as CKD-mineral bone disorder (MBD). Klotho, a causative protein of aging, and fibroblast growth factor 23 (FGF23...

...-o M, Matsumura Y, Aizawa H, et al: Mutation of the mouse Klotho gene leads to a syndrome resembling ageing. Nature 1997;390:45-51. 10. Kurosu H, Yamamoto M, Clark JD, et al: Suppression of aging in mice by the hormone Klotho. Science 2005;309:1829-1833. 11. Hu MC, Shi M, Zhang J, et al...

...References References 1. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI: Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997;390...

... degradation. Nonglycosylated FGF-23 may be targeted for degradation by subtilisin/furine-like endopeptidases ( fig. 1 ). Impaired FGF- 23 synthesis or action, due to FGF- 23 gene mutations, mutations in GALNT 3, or mutations in Klotho, which is required for the conversion of FGFR1(IIIc) into the FGF- 23...

... as a novel therapeutic target [ 28 ]. Exploration of the functional properties of TLTs in the aged kidney can be an area for future investigation. Decreased Klotho Levels Klotho is expressed in the kidney, mainly in the distal convoluted tubule. Membrane-bound Klotho is a co-receptor for fibroblast...

... insights into fibroblast growth factor (FGF) 23 have led to marked advancement in interpreting data on CVD and CKD progression ascribing to FGF23 a pivotal role in these pathologies independent of its co-receptor klotho and well beyond mineral metabolism. This review article will discuss the current...

... KLOTHO causes severe tumoral calcinosis. J Clin Invest 2007;117:2684-2691 11. Shimada T, Hasegawa H, Yamazaki Y, Muto T, Hino R, Takeuchi Y, Fujita T, Nakahara K, Fukumoto S, Yamashita T: FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis. J Bone Miner Res 2004;19:429-435...

... are influenced by the enzyme Klotho. Klotho is a 130-kDa transmembrane β-glucuronidase that catalyzes the hydrolysis of steroid β-glucuronides and was discovered by Kuro-o et al. [ 16 ] in 1997. The Klotho gene is expressed in a limited number of tissues, mainly the kidneys, and mutations cause multiple age...

....2020.02.023. 45. Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997 Nov;390(6655):45–51. 46. Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, et al. Suppression of aging in mice...

...-acetylgalactosaminyl-transferase 3 and secreted into the circulation. FGF23 binds with high affinity to fibroblast growth factor receptor 1c in the presence of its co-receptor Klotho. It inhibits, either directly or indirectly, reabsorption of phosphate and the synthesis of 1,25-dihydroxy-vitamin-D by the renal...

... pathophysiological step in the AKI-to-CKD transition and the acceleration of senescence processes characterized the maladaptive response that links AKI to CKD [ 30 ]. Several signaling pathways have been suggested to be key factors in this scenario. α-Klotho is a recognized anti-aging factor and the kidney plays...

... tubular epithelial cells in vivo [ 18 ]. Klotho is a 130-kDa transmembrane β-glucuronidase that catalyzes the hydrolysis of steroid β-glucuronides and that was discovered by Kuro-o et al. [ 19 ]. The Klotho gene is expressed in a limited number of tissues, and mainly in kidney tissue, and mutations...

... kidney disease and dialysis patients. Nutrients 2017;9:328. 15. Brown AJ, Dusso A, Lòpez-Hilker S, et al: 1,25-(OH)2D receptors are decreased in parathyroid glands from chronically uremic dogs. Kidney Int 1989;35:19-23. 16. Kumata C, Mizobuchi M, Ogata H, et al: Involvement of alpha-Klotho...

..., there is increasing evidence to indicate that during normal bone metabolism, vitamin D plays a direct role in optimizing the activity of bone cells, as recently shown [ 21 ]. New hormones Klotho in a hormone's clothing? Circulating levels of soluble klotho and FGF23 in X-linked hypophosphatemia: circadian...

... downregulates the expression of both type IIa and type IIc sodium-phosphate cotransporters on the apical surface of renal proximal tubular epithelial cells in vivo [ 15 ]. The effects of FGF-23 are influenced by the expression of Klotho, a 130-kDa transmembrane β-glucuronidase that catalyzes the hydrolysis...

... Viciana AC, Sanches TR, Dos Santos F, Helou CMB, et al. Chronic nicotine exposure reduces klotho expression and triggers different renal and hemodynamic responses in klotho-haploinsufficient mice. Am J Physiol Renal Physiol. 2018;314(5):F992–F8. 20. Jaimes EA, Tian RX, Joshi MS, Raij L. Nicotine...

... FGF23-R179Q on dietary phosphate regulation of the renal type II Na/Pi transporter. Pflugers Arch 2003;446:585-592. 16. Kuro-o M, Matsumura Y, Aizawa H, et al: Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 1997;390:45-51. 17. Kurosu H, Ogawa Y, Miyoshi M, et al...

... ]. The Klotho-Deficient Mouse: A Model of Disrupted Osteoblasts, Osteoclasts, and Osteocytes and Defects in Mineral Metabolism The klotho gene deficient mouse is also considered a valid model for an accelerated aging state mimicking a number of gerontological pathologies such as osteoporosis, skin...