1-20 of 2538 Search Results for

kinase

Follow your search
Access your saved searches in your account

Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Book Chapter
Book
Book
Book
Book Chapter
Book
Book Cover Image
Published: 27 August 2018
10.1159/isbn.978-1-910797-89-1
EISBN: 978-1-910797-89-1
Book Chapter
Series: Developments in Ophthalmology
Volume: 55
Published: 27 October 2015
10.1159/000431204
EISBN: 978-3-318-05565-8
... Abstract The isozyme protein kinase C (PKC) β is involved in several processes that are deregulated in different retinal cell types by hyperglycemia. This family of serine/threonine-specific protein kinases comprises several different members, which differ in their structure, cofactor...
Book Chapter
Series: Pediatric and Adolescent Medicine
Volume: 20
Published: 28 September 2015
10.1159/000382093
EISBN: 978-3-318-05497-2
... Abstract Anaplastic lymphoma kinase (ALK) is a membrane-bound receptor tyrosine kinase that when aberrantly expressed is capable of promoting neuroblastoma pathogenesis, and serves as a bona fide therapeutic target. In this review, we discuss the physiologic role of ALK, the mechanisms...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320828
EISBN: 978-3-8055-9567-4
...The target The transforming growth factor-ß (TGF-ß) receptor complex is a tetramer consisting of two dimers: two TGF-ß type II and two type I receptors (TGF-ßRII and TGF-ßRI) ( Fig. 1 ). TGF-ßRII and TGF-ßRI (also known as activin receptor like kinase 5 or ALK5) are transmembrane serine...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320832
EISBN: 978-3-8055-9567-4
...Mechanism of action and rationale Spleen tyrosine kinase (Syk) is a nonreceptor tyrosine kinase which has been proposed to play a key role in immuno-globulin E (IgE)-mediated allergic responses ( 1 - 5 ). In allergic asthmatics and rhinitics, inhaled allergens bind to high-affinity IgE...
Book Chapter
Series: Progress in Respiratory Research
Volume: 39
Published: 31 August 2010
10.1159/000320833
EISBN: 978-3-8055-9567-4
...The target The Ser/Thr kinase protein kinase C-θ (PKC-θ) is highly expressed in T cells, thymocytes and skeletal muscle, and is also found in platelets, lung and brain ( 1 , 2 ). PKCs are classified into three subfamilies i): conventional (PKC-α, PKC-β, PKC-γ), which require both Ca 2...
Book Chapter
Series: Frontiers of Neurology and Neuroscience
Volume: 26
Published: 20 April 2009
10.1159/000212372
EISBN: 978-3-8055-9142-3
... Abstract Background/Aims: To summarize current understanding of muscle-specific receptor tyrosine kinase antibody (MuSKAb)-positive and seronegative myasthenia gravis (MG). Methods: We reviewed the current literature on MuSK and seronegative MG, and placed lighter emphasis on seronegative...
Book Chapter
Series: Frontiers of Hormone Research
Volume: 36
Published: 19 February 2008
10.1159/000115366
EISBN: 978-3-8055-8430-2
... Abstract AMP-activated protein kinase (AMPK) is a major regulator of energy metabolism at both the cell and atthe whole body level. Numerous genetic and obesity models as well as human studies have suggested arole for AMPK in the physiological regulation of fatty acid and glucose metabolism...
Book Chapter
Series: Developments in Ophthalmology
Volume: 39
Published: 22 January 2007
10.1159/000098506
EISBN: 978-3-318-01439-6
.... Newer therapeutic options are directed at thecausative mechanisms of diabetic retinopathy. Experimental and clinical evidence suggeststhat pharmacological compounds like protein kinase C subtype β (PKC-β) inhibitors may beeffective in the treatment of diabetic retinopathy. One important pathomechanism...
Book Chapter
Book Chapter
Book Chapter
Book Chapter
Book Chapter
Book Chapter
Series: Progress in Respiratory Research
Volume: 31
Published: 08 March 2001
10.1159/000062169
EISBN: 978-3-318-00424-3