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keratin

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Book Chapter
Series: Current Problems in Dermatology
Volume: 11
Published: 02 November 1983
10.1159/000408682
EISBN: 978-3-318-03448-6
... Abstract SummaryThe four major epidermal keratins (65–67K, 58K, 56K, and 50K) have been localized in various cell layers of normal human epidermis. Guinea pig antisera and mouse monoclonal antibodies were prepared against human epidermal keratins and were characterized with respect...
Book Chapter
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/000396298
EISBN: 978-3-318-03447-9
... Abstract The stratum corneum basic protein (SCBP) aggregates specifically with keratin filaments, forming macrofibrils in which the filaments are highly aligned. The appearance of the macrofibrils formed in vitro is similar to the keratin pattern in the intact stratum corneum, suggesting...
Book Chapter
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/000396300
EISBN: 978-3-318-03447-9
... that they may be located in the nonhelical regions.The polypeptide composition of keratins has been studied by SDS polyacrylamide gel electrophoresis, and heterogeneity in the polypeptide components can be demonstrated between species, within a species, and in different areas of skin of a single member...
Book Chapter
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/000396303
EISBN: 978-3-318-03447-9
... Abstract The chemistry and structure of the epidermal α-keratin extracted from the skin of patients with a variety of disorders of keratinization have been investigated using biochemical, biophysical, and electron microscopic techniques developed for the characterization of normal mammalian...
Book Chapter
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/000396304
EISBN: 978-3-318-03447-9
... Abstract Keratin extracted from keratinized cells of newborn rats polymerizes into filaments in vitro and this polymerization has been shown to be greatly stimulated by addition of divalent cations. In this study we investigated the optimum conditions for filament formation by use of CaCl2...
Book Chapter
Series: Current Problems in Dermatology
Volume: 6
Published: 26 July 1976
10.1159/000399006
EISBN: 978-3-318-03443-1
Book
Book Cover Image
Series: Current Problems in Dermatology
Volume: 6
Published: 26 July 1976
10.1159/isbn.978-3-318-03443-1
EISBN: 978-3-318-03443-1
Book Chapter
Book Chapter
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/000396299
EISBN: 978-3-318-03447-9
... Abstract Cultures of human keratinocytes were established according to the technique of Rheinwald and Green.1 When cultures were exposed to [14C] leucine, the uptake of leucine and increase in the specific activity of 6 urea-extractable polypeptides was prompt—each keratin achieved 50% of its...
Book Chapter
Book Chapter
Book Chapter
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/000396280
EISBN: 978-3-318-03447-9
.... It was concluded that dibutyryl cyclic AMP stimulated the protein synthesis of the cultured keratinocytes and induced a qualitative change toward accelerating the synthesis of keratinous protein. ...
Book Chapter
Series: Current Problems in Dermatology
Volume: 10
Published: 29 April 1981
10.1159/000396286
EISBN: 978-3-318-03447-9
... Abstract The distribution patterns of nuclear DNA and RNA in normal and abnormal keratinizing tissues of human skin were examined by electron microscopy, using an enzyme digestion technique. We found that the distribution of nucleic acids in the nuclei of epidermal cells during keratinization...
Book Chapter
Book Chapter
Series: Current Problems in Dermatology
Volume: 6
Published: 26 July 1976
10.1159/000399005
EISBN: 978-3-318-03443-1
Book Chapter
Series: Current Problems in Dermatology
Volume: 6
Published: 26 July 1976
10.1159/000399007
EISBN: 978-3-318-03443-1
Book Chapter
Book Chapter
Series: Current Problems in Dermatology
Volume: 6
Published: 26 July 1976
10.1159/000399009
EISBN: 978-3-318-03443-1
Book Chapter
Book Chapter
Series: Current Problems in Dermatology
Volume: 11
Published: 02 November 1983
10.1159/000408662
EISBN: 978-3-318-03448-6
... of cultured human epidermal cells. Cloned hybrid plasm ids containing 45–95 % of the sequences present in keratin, actin, and tubulin mRNAs were isolated and characterized. To identify the cDNAs encoding the four major keratins of human epidermal cells, the clones were initially screened for their ability...