... Abstract Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare but severe adverse cutaneous drug reactions that are to be considered medical emergencies. The average reported mortality rate for SJS is 1–5%, and up to 25–35% for TEN. TEN and SJS are characterized by more...

... Abstract Stevens-Johnson syndrome (SJS) and toxic epidermalnecrolysis (TEN) are the most severe forms of hypersensitivityreactions affecting the skin. They are best consideredseverity variants of a single disease on the basis of similarpathology (epidermal necrolysis), risk factors, causes...

... and the benzimidazolylpiperazine, JNJ-10191584 (VUF-6002), have been extensively reported by workers at Johnson & Johnson Pharmaceutical Research & Development, L.L.C. and others ( 23 , 30 - 32 ). The patent literature reflects that several other pharma and biotech companies have been actively investigating H 4 R...

...–1813. 72. Lange WR, Fudala PJ, Dax EM, Johnson RE: Safety and side-effects of buprenorphine in the clinical management of heroin addiction. Drug Alcohol Depend 1990;26:19–28. 73. Uemura N, McCrea J, Sun H, Donikyan M, Zammit G, Liu R, et al: Effects of the orexin receptor antagonist suvorexant...

... including reactions of both delayed and immediate hypersensitivity, such as maculopapular exanthema, fixed drug eruption and urticaria. Concerning rare but life-threatening severe cutaneous adverse reactions, e.g. toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), acute generalized...

...) and the blistering reactions (Stevens-Johnson syndrome, toxic epidermal necrolysis), also termed serious cutaneous adverse drug reactions, being the most severe and most feared. There is increasing evidence for the role of the immune system in the pathogenesis of these reactions, with drug-specific T cells having...

... presents with a wide spectrum of clinical manifestations indistinguishable from those of other skin diseases, such as erythema multiforme, Stevens-Johnson syndrome /toxic epidermal necrolysis, cellulitis, paronychia, lichen planus, and parapsoriasis en plaques. These unusual forms of FDE are likely...

... Abstract Aqueous tear deficiency due to lacrimal gland insufficiency is one of the major causes of dry eye. In severe cases, such as Sjoegren’s syndrome, Stevens-Johnson syndrome or ocular cicatricial pemphigoid, therapy with artificial tears can be insufficient to relieve severe discomfort...

... Abstract When President Lyndon Johnson signed the Medicare and Medicaid bill into law in 1965, it ended the 46-year campaign to enact a healthcare program for senior citizens and started what is now a 42-year effort by the American Dietetic Association (ADA) and its members to expand its...

... of the conjunctiva is important for themanagement of dry eye. Materials and Methods: Conjunctival diseases associated with dryeye include conjunctivochalasis, superior limbic keratoconjunctivitis, pterygium and pinguecula,and severe ocular surface diseases such as Stevens-Johnson syndrome and ocular...

... Abstract Toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome(SJS), acute generalized exanthematous pustulosis(AGEP) and hypersensitivity syndrome (HSS), which is alsocalled drug reaction with eosinophilia and systemic symptoms(DRESS), are severe cutaneous adverse reactions(SCARs...

... predicted, particularly with the use of the genes codingfor major histocompatibility complex (MHC), a key moleculefor immune response. The genetic predisposition isdrug- and phenotype-specific, HLA-B * 1502 is associatedwith carbamazepine-induced Stevens-Johnson syndrome(SJS) and toxic epidermal necrolysis...

... of even more severedrug reactions like Stevens-Johnson syndrome, toxicepidermal necrolysis or a drug rash with eosinophilia andsystemic symptoms. In most cases, management includesearly withdrawal of the offending drug and usually supportivetreatment with emollients, topical corticosteroids andsystemic...

... to find similar written manifestations ofvocal tics in the work of authors suffering from Tourette’s syndrome. This is neither the casein the work of Samuel Johnson (1709-1784) nor in that of André Malraux (1901-1976). Inconclusion, Tourette’s syndrome is an inventive but implausible diagnosis...