... Abstract SummaryFourteen cooperative patients with extrinsic asthma (positive history and skin tests with inhalation allergens, sputum eosinophilia, isoprenaline reactive bronchial obstruction) were treated during two weeks with lactose-isoprenaline-powder-inhalations, then during three weeks...

... in asystole [Grant, 1968; Miller and Semple, 1967].Recent experiments by Collins [1969] have now shown that under hypoxic conditions the heart of dogs arrests in asystole preceded by bradycardia when exposed to moderately large amounts of isoprenaline; the usual effect of isoprenaline being reversed.It...

... in 1964. Altounyan first tested it in February 1965 when it gave 72% protection at 2 h and >50% at 6 h. It therefore met the profile identified by the research group and a programme started culminating in the launch of Intal Compound (20 mg of disodium cromoglycate with 0.1 mg of isoprenaline and 20 mg...

... pressure and relaxes the uterus. Catecholamine receptors persisted in this wavering state for more than 40 years. Additional blocking agents became available, but only for the smooth muscle excitatory receptors. Additional agonists were also synthesized. Outstanding among them became isoprenaline, N...

...: The role of long-acting bronchodilators in the management of stable COPD. Chest 2004;125:(1)249-59 6. Watson N, Eglen RM: Effects of muscarinic M 2 and M 3 receptor stimulation and antagonism on responses to isoprenaline of guinea pig trachea in vitro. Br J Pharmacol 1994;112:(1)179-87 7. Hanania...

...% ethanol, nor did they affect the adaptive cytoprotection of mild irritants. On the contrary, isoprenaline, a β-adrenoceptor agonist, reduced dose-dependently the ethanol-induced mucosal injury and this effect was accompanied by an elevation of the gastric blood flow. Suppression of nitric oxide...

.... Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 1940;195:71-74. 73. Konzett H: Neue broncholytisch hochwirksame Körper der Adrenalinreihe. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol 1941;197:27-40. 74. Konzett H: On the discovery of isoprenaline. Trends Pharmacol Sci 1981;2:47-49. 75...

... in the presence of various concentrations of isoprenaline and insulin [ 17 ]. In this muscle preparation, hyperthyroidism increased the rates of lactate formation and suppressed those of glycogen synthesis in response to isoprenaline, even in the presence of physiological or supraphysiological concentrations...

... in development for the treatment of asthma and COPD. Indacaterol is a nearly full β 2 -agonist with high intrinsic efficacy. Unlike partial agonists, it does not exhibit antagonistic behavior in the presence of isoprenaline ( 10 ). Potency and intrinsic efficacy have been demonstrated in various models...

... bronchodilators in the management of stable COPD. Chest 2004;125:(1)249-59 6. Watson N, Eglen RM: Effects of muscarinic M 2 and M 3 receptor stimulation and antagonism on responses to isoprenaline of guinea pig trachea in vitro. Br J Pharmacol 1994;112:(1)179-87 7. Hanania NA: Optimizing maintenance...

... reflect changes in the neural input to the glands from mechanoreceptors located in the periodontal ligament or the gingiva [ 16 ]. Enlargement of normal glands can be caused in vivo by the chronic administration of isoprenaline, a ß-adrenergic agonist (mimicking sympathetic neural activity). These studies...