... Abstract Due to high iron requirements, young children are at risk for iron deficiency anemia. Iron supplements are therefore often recommended, especially since iron deficiency anemia in children is associated with poor neurodevelopment. However, in contrast to most other nutrients, excess...

... Abstract Use of intravenous iron in children has been limited due to concerns regarding adverse effects. However, newer preparations of intravenous iron have been shown to be effective and associated with fewer side effects in adults as well as in preliminary studies involving children...

... Anemia Iron deficiency Oxygen Ferritin Hepcidin Key Messages Anemia is the inability of the blood to deliver the requisite oxygen to the tissues of the body, but only a portion of anemic states are related to iron deficiency. More iron deficiency is caused by poor absorption...

...Key Messages The microminerals iron, zinc, copper, selenium, manganese, iodine, chromium and molybdenum have important physiological functions. It is important to provide adequate amounts of microminerals in the diet since preterm infants are at increased risk of micromineral deficiencies...

... Abstract Almost 300 million children under 5 years of age are anemic worldwide. International policymakers recommend universal distribution of iron-based interventions – either iron supplements or iron-containing multiple micronutrient powders – to alleviate the burden of anemia in young...

.... Treatment therefore involves erythropoiesis-stimulating agents (ESAs). Optimal erythropoietic response to ESA therapy also requires adequate iron management. However, iron metabolism is also dysregulated in CKD patients. Summary: During erythropoiesis, biomarkers of iron metabolism are dramatically...

... Abstract Normal iron metabolism is essential for effective hemoglobin (Hb) production in the management of renal anemia. Considering that studies regarding the optimal Hb levels predated the creation of the iron management indices found in the treatment guidelines for hemodialysis (HD) patients...

... Abstract Iron deficiency, one of the most widespread nutritional disorders, affects millions of people in emerging economies and, increasingly, in industrialized countries. Due to the high iron requirements during growth and development, infants and young children are among those most severely...

... Abstract Iron is needed for oxygen transport, muscle activity, mitochondrial function, DNA synthesis, and sensing of hypoxia. The hierarchical master determinant of dietary iron absorption and iron distribution within the body is the peptide hormone hepcidin. Hepcidin itself is regulated...

... Abstract The two main causes of death in patients on maintenance hemodialysis (MHD) are cardiovascular disease and infection. In the current report, we discuss the association of the iron-catalyzed Fenton reaction and iron sequestration with complications in MHD patients. In particular, we have...

... Abstract This article looks back on the development of both stem cell transplantation and iron chelation in the treatment of thalassaemia major. The parallel evolution of these two alternative treatments in the 1980s and 1990s, without the benefit of an appropriate clinical trial, has left us...

... results, and sub-analyses by timing of intervention and amount of iron were also done. The primary outcome measures were birthweight, low birthweight (LBW; <2,500 g) and small for gestational age (SGA). Prenatal MM supplementation significantly reduced the incidence of LBW (risk ratio, RR: 0.86; 95% CI...

... infants are larger (1,500-2,500 g), and the most common nutritional problem of those infants is iron deficiency (ID). Globally, about 25% of pre-school children have ID anemia (IDA), the most severe form of ID, and there is good evidence that ID is associated with impaired brain development. However...

...Comments by Discussant The presentation highlighted that micronutrient deficiencies, particularly iron deficiency, are very common in low birthweight infants and extend into later life. Of particular concern is the high incidence (25-50%) of iron deficiency reported in pre-school children...

... Abstract Anemia is a significant cause of morbidity and lowers the quality of life of patients suffering from chronic kidney disease (CKD). Iron deficiency is the most important cause of erythropoietin (EPO) hyporesponsiveness in CKD. EPO administration significantly increases the costs of CKD...