... effectiveness (RBE). There is strong rationale for applying such treatment in patients with intracranial gliomas. In cases of low-grade tumors, the main benefits may be related to potential decrease of long-term morbidity, whereas in cases of high-grade neoplasms, the use of modalities with greater RBE may lead...

... in the evolution of gliomas. Cancer Sci 2009;100:2235-2241. 25. Michaud K, Solomon DA, Oermann E, Kim JS, Zhong WZ, Prados MD, Ozawa T, James CD, Waldman T: Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. Cancer Res 2010;70...

... at the intracranial tumor site and frequently results in systemic toxicities. To overcome this obstacle, several options for targeted local therapy have been investigated, and various methods for intracranial administration of the pharmacological agents were introduced, including intratumoral injections, implantation...

... and limiting irradiation of normal tissue. Introduction Fractionated radiotherapy (FRT) has been utilized in the management of intracranial gliomas for many decades. This chapter introduces the basic concepts in the delivery of fractionated radiation and presents a literature review on results of its...

... recurrent after previous surgery and FRT can experience a benefit from SRS. Ependymoma (WHO Grade II) Ependymomas make up 5% of all intracranial neoplasms with about 30% occurring in children under the age of 3 [ 23 ]. The role of SRS in their management is marginal, and opinions of medical...

... I) seeds as possible therapy of intracranial gliomas is currently undergoing a definite revival, and several indications for its use have been identified. Generally, 125 I-BT may be considered a reasonable option in cases of unresectable, well-circumscribed, either newly diagnosed or recurrent...

.... Further improvements of outcome after radiation treatment of pediatric gliomas may be expected with wider application of intensity-modulated radiation therapy (IMRT), proton therapy, and stereotactic techniques, including brachytherapy. Introduction Irradiation of intracranial gliomas in pediatric...

... Abstract Under specific indications, chemotherapy may play an important role in the treatment of pediatric patients with intracranial gliomas. It can be effectively administered in inoperable low-grade tumors, particularly with the use of combination regimens based on carboplatin...

... and psychological rehabilitation. While existing data on the effectiveness of such treatment in patients with intracranial glioma are limited and inconsistent, it is possible to suggest that systematic and multidisciplinary rehabilitation plays a very important therapeutic role and leads to improvements...

... for effective management of neurological symptoms and complications directly or indirectly caused by the intracranial lesion. The concept of palliative care in neuro-oncology is an emerging issue. Despite their high importance, the ongoing needs of such therapy in patients with malignant brain tumors from...

... Abstract Gliomas are the most common primary intracranial neoplasms, which cause significant mortality and morbidity that is disproportionate to their relatively rare incidence. Many potential risk factors for glioma have been studied to date, but only few provide explanation for the number...

... Abstract Combined use of contemporary radiological modalities, particularly integration of structural, metabolic, and functional imaging, provides optimal multifaceted information for detailed characterization of intracranial gliomas. It allows differentiation of the tumor from non-neoplastic...

... stereotactic biopsy or very limited debulking of lesions for tissue diagnosis only, to more extensive tumor resections which relieve mass effect, lower intracranial pressure, reduce accompanying brain edema, and attenuate dependence on steroids. Achieving a clinically significant cytoreduction makes adjuvant...

... the context of neurosurgical training and its implications for resection of intracranial gliomas. VR holds the promise of providing a useful educational tool for neurosurgical residents to hone their surgical skills and for neurosurgeons to rehearse specific segments of the surgery prior to the actual...

... Abstract Aggressive resection of intracranial gliomas has a positive impact on patients' prognosis, but is associated with a risk of neurological complications. For preservation of brain functions and avoidance of major postoperative morbidity various methods of intraoperative...

... of complications. Between 1998 and 2009, 1,652 patients with intracranial gliomas, including 121 tumors affecting deep-seated and midline brain structures, underwent surgery in the Department of Neurosurgery of the Tokyo Women's Medical University headed by the first author. More recently, he operated on four...

... Abstract Gliomas are the most common type of brain cancer in the pediatric patients, constituting about 50% of all childhood intracranial tumors. This is a highly heterogeneous group, varying from the benign WHO histopathological grades I and II to malignant WHO grades III and IV. The histology...