... injuries. Etiology and Pathomechanism The first and second tarsometatarsal joints combined, represent the Lisfranc joint complex [ 1 ]. Instability can result from trauma or degeneration change. In hallux valgus deformity the role of tarsometatarsal (TMT) instability of the first TMT joint remains...

... Abstract Late-life aging in humans is often associated with severe frailty. This suggests catastrophic events reaching an undeniable biological threshold in cellular stability and a rapidly diminished homeostasis. The driving force of the syndrome is likely ‘genetic instability' or ‘genomic...

... be associated with tendon lesion and instability, developing the ‘terrible triad’ of the shoulder. Both conservative and surgical management are possible, and surgeons must choose the most appropriate management modality according to the biologic age of the patients, functional demands, and type of lesion...

... Abstract Chromosomal instability (CIN) is a hallmark of many cancer cells. Several cellular mechanisms have beenproposed to lead to CIN, including abnormal centrosome replication, defects in spindle assembly checkpoint,failed DNA repair and telomere dysfunction. Human T cell leukemia virus 1...

... Abstract Colorectal cancer (CRC) still represents the model of choice to study the mechanismsunderlying tumor initiation and progression. Accordingly, CRC has been central in the analysisof the role played by chromosomal instability (CIN) in tumor initiation and progression.Although loss of APC...

..., despite the plethora of information gathered, the exact role and mechanismof action of the protein still remains enigmatic. This review focuses on the role of thec-Myc protein in the induction of genomic instability and its link with the development ofcancer. We briefly describe c-Myc protein, its binding...

... Abstract Fanconi anemia (FA) is a rare recessive disease that reflects the cellular and phenotypicconsequences of genetic instability: growth retardation, congenital malformations, bone marrowfailure, high risk of neoplasia, and premature aging. At the cellular level, manifestationsof genetic...

... A 76-year-old female, suffering from a chronic severe hallux valgus deformity with tarsometatarsal (TMT)-I-II instability and metatarsalgia II-III left foot ( Figs. 1, 2 ). Fig. 1. AP weight-bearing X-ray showing a severe hallux valgus deformity with pronation of the Ist metatarsal...

... of the injury to the plantar structures can range from a moderate sprain to a complete disruption, depending on the degree of stress placed on the foot [ 3 ]. Even though acute trauma accounts for 16% of cases of MTP joint instability, it is more often caused by a chronic, degenerative condition...

... 1979;540-543 24. Neviaser RJ, Neviaser N: Recurrent instability of the shoulder after age 40. J Shoulder Elbow Surg 1999;4:416-418 25. Kim TK, Rauh PB, McFarland EG: Partial tears of the subscapularis tendon found during arthroscopic procedures on the shoulder: a statistical analysis of sixty cases...

... Abstract A tarsometatarsal-1 joint (TMT1) fusion is commonly performed for hallux valgus correction, instability or degenerative changes of the joint. Several concepts for osteosynthesis of the joint have been described. Plantar plating has the potential advantage to screw osteosynthesis...