... Abstract Late-life aging in humans is often associated with severe frailty. This suggests catastrophic events reaching an undeniable biological threshold in cellular stability and a rapidly diminished homeostasis. The driving force of the syndrome is likely ‘genetic instability' or ‘genomic...

... be associated with tendon lesion and instability, developing the ‘terrible triad’ of the shoulder. Both conservative and surgical management are possible, and surgeons must choose the most appropriate management modality according to the biologic age of the patients, functional demands, and type of lesion...

... Abstract Chromosomal instability (CIN) is a hallmark of many cancer cells. Several cellular mechanisms have beenproposed to lead to CIN, including abnormal centrosome replication, defects in spindle assembly checkpoint,failed DNA repair and telomere dysfunction. Human T cell leukemia virus 1...

... Abstract Colorectal cancer (CRC) still represents the model of choice to study the mechanismsunderlying tumor initiation and progression. Accordingly, CRC has been central in the analysisof the role played by chromosomal instability (CIN) in tumor initiation and progression.Although loss of APC...

..., despite the plethora of information gathered, the exact role and mechanismof action of the protein still remains enigmatic. This review focuses on the role of thec-Myc protein in the induction of genomic instability and its link with the development ofcancer. We briefly describe c-Myc protein, its binding...

... Abstract Fanconi anemia (FA) is a rare recessive disease that reflects the cellular and phenotypicconsequences of genetic instability: growth retardation, congenital malformations, bone marrowfailure, high risk of neoplasia, and premature aging. At the cellular level, manifestationsof genetic...

... 1979;540-543 24. Neviaser RJ, Neviaser N: Recurrent instability of the shoulder after age 40. J Shoulder Elbow Surg 1999;4:416-418 25. Kim TK, Rauh PB, McFarland EG: Partial tears of the subscapularis tendon found during arthroscopic procedures on the shoulder: a statistical analysis of sixty cases...

... treatment times enhances the risk for hemodynamic instability as well asfor inadequate depuration. The traditional management of the dialysis session, setting of predefinedtreatment parameters, with active therapeutic interventions only in the event of complications,is definitely unsuitable for short...

... children’s social (emotional instability, prosocial and aggressive behavior) and psychological (depressive symptoms) adjustment. Results revealed that in spite of lower socioeconomic status, immigrant children, but not their teachers, reported lower levels of emotional instability and aggression. Gender...

... of the disabling headaches and associated symptoms. We hypothesize that lateral C 1 -C 2 instability-induced transient vertebral artery compression explains the CCS, and that fixation resolves the syndrome. As a result of the 10.8 million motor vehicle accidents (MVA) occurring annually in the USA [ 1...